<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07934

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFHKARNKDEYLGFVARLILHVREMNTKHKNQQNAAAAAAAAAQQAQQDGGGNSSQQGGGGGGGGSGMPDPINALQTLASQGTRPQMMGQMGVGPGGPMGGQMGGAGQASNLLHSLRPQMQMGGMGVPMQGNRVGMGPGNQMGGMMGGPNQMQGPGAGMVGGMPGQMGVGIGPGGMSGGKIVGMGGQQQQMAQLNAMQVNQMQQAQQQQGGMPQPQQQQQQGGIAQGQGVPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQNAMAGQQMGSVGGTMNAGNQMGQMVGANAVMNPQAMGMATNQVLRQQQQQQQQGMGQVQMGLGP
Length365
PositionTail
OrganismAnopheles christyi
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.01
Grand average of hydropathy-0.603
Instability index44.56
Isoelectric point10.08
Molecular weight37445.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07934
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     251.71|      31|      32|     159|     189|       1
---------------------------------------------------------------------------
  126-  146 (47.98/ 8.72)	PQM.MGQM....GV.........GPG..GPMGGQMGG
  159-  189 (74.74/18.64)	PQMQMGGM....GVPMQGNRVGMGPG..NQMGGMMGG
  228-  256 (41.96/ 6.49)	QQQQMAQL....N.AMQVNQ..MQQA.qQQQGGMPQP
  258-  292 (45.79/ 7.91)	QQQQQGGIaqgqGVPVQ..QMGVGPGgpNQMNPMVMG
  305-  328 (41.24/ 6.22)	AGQQMGSV....G....GT...MNAG..NQMGQMVGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.10|      15|      16|     195|     209|       2
---------------------------------------------------------------------------
  100-  114 (28.47/ 6.84)	GGGGGGGSGMPDPIN
  195-  209 (33.43/ 9.41)	GPGAGMVGGMPGQMG
  213-  226 (28.19/ 6.69)	GPG.GMSGGKIVGMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.16|      14|     262|      85|      99|       3
---------------------------------------------------------------------------
   85-   99 (22.75/ 8.43)	QQAQQDGGGnSSQQG
  349-  362 (28.41/ 8.06)	QQQQQQGMG.QVQMG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07934 with Med15 domain of Kingdom Metazoa
Unable to open file!