<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07932

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPSGGGGGGGGGGNGTGGGSAANSNEGGQQQQQTQANSNMGNSSSSSSSGSNSSSSNSNSLNTLKASPRSSLSSSGIGSLKVRSESSLGAGSGGSIGSGSGVPMTPSIHSVFSSAHQTALANNLASKRESILQMLQSLKRPSLFCKDYETLQSEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAAEENRLVKKIRNLDLYANEHSRTMAVGGFGGSNAIGMPGGNSVGGTNGMLMKGAAEASEALAEALSCVRSGSGGVGACDNGASNNGGCPPLLGQIKMEIGCDGSQGGVAGAGGGLGSANGGTPDRNGAASGNGDGALLGEHEIKKEKEDKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDNHPNSSPGGGGCLSDGGIAIDTLVDLQMSLSSGAGSSGSGAGPAIPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPTLPSQLVMPSIPTNTVAGLVYKSTRQKQKEQAAAEREKQKLREQADREREQQQQQDQQQNAQSENSTQSAGGSGTSVGAIGTVTGSVGLGLLPIIKQEVGGLTVPQPLSTPNSLLGGLNNLNGSLNHPYSNPPSQGAQSQPHSRPPSVNSLPGGIIGGAGMLSPSPAGAGSSGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAAAGSPNPMGSLNFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQYPLDGVDSGGPGSNRGPMTPSSTGGPLGTTTVNPPLSSTGVGCAIGSNGTPGSRSTSIETNALLVNILLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLALPGTNWMDSVTASADTASGATGGSGGGVGGVGRSKANALAHLGLSGGGSSSSAFGGMLGSPAVGSVNDKTVTINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKKSSLFEFLNGTAKAIKLEDTGSGGSSGTLATTGSTAGASGSDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGPLFGRGTENGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQSSSGSNGSPGSGALVKGGTLRGMMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLVVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDFVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGTGSSAASSSSPSSSSSSSSSTSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSSSSASASIGGGTPGASSLGSGSMGQPGGNAMGQNRNDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIVSLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFMKRKDEKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEDTSYQPRQPAECRTRFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2088
PositionMiddle
OrganismAnopheles christyi
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.457
Instability index53.87
Isoelectric point5.94
Molecular weight219703.13
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07932
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     637.02|      83|      84|     614|     696|       1
---------------------------------------------------------------------------
   28-  117 (93.16/27.22)	TPAPTPTDQH.....DSKSINASP.......................yHTP........SHPS...............G..GGG.GG.GGGG....NGTGGGS........AA.....NSNEG.......GqqqqqTQ.............AN..SNMgnssssssS............GS.........NSSSSNSN..SL.N.....TLKA
  258-  318 (40.56/ 7.43)	......................................................................................M.AVGG....FG...GSNAIG..MPGG.....NS.VG.......G.....TNgmlmkgaaeaseaLA..EAL........S............CV.........RSGSGGVG..ACdN.....GASN
  319-  409 (56.16/13.30)	.NGGCPPLLGqikmeIGCDG............................SQG........GVAG...............A..GGGlGS.ANGGtpdrNGAASGN.GDGaLLGEHeikkeKEDKG.......S.....I....................F........L............TD.........QDLQPSID..DL.NqifddGG..
  410-  471 (81.45/22.81)	.PFN...........DDPDLHNTP........................P.G........SNKS...............S..SGS.GG.FSEE....SKRFPSS...............NHH................S.............VN..SGM........L............SP.........KELSQMFP..TP.P.....SLDN
  472-  520 (39.55/ 7.06)	HPNSSPGGGG.....CLSDGGIAI.........................DTlvdlqmslSSGA..................GSS.GS.GAGP....AIPNLGS..............................................................................................................
  614-  677 (86.70/24.79)	................................................SEN........STQS...............A..GGS.GT.SVGA....IGTVTGSVGLG.LLPII.....KQEVG.......G.....LT.............VP..QPL........S............TP.........NSLLGGLN..NL.N.....GSLN
  678-  764 (99.84/29.73)	HPYSNPPSQG.....AQSQPHSRP.......................pSVN........SLPG...............GiiGGA.GMlSPSP....AG..AGSSG.G.LF........HPGMG.......G.....IP.............VPlrQGM........S..........piSP.........ATPGGSMRvpTP.Q.....GSCP
  765-  895 (72.14/19.31)	LPYPSPLGGA.....AAGSPN..PmgslnfrrttpllppppydvaiasPAN........SVATpssyhskqypldgvdS..GGP.GS.NRGP....M..TPSSTG.G...PL..........G.......T.....TT.............VN..PPL........SstgvgcaigsngTPgsrstsietNALLVNIL..LY.D.....TALN
 1452- 1518 (67.45/17.55)	................................................HTS........SSSS...............A..SAS.IG.GGTP....GASSLGSGSMG.Q.PGG.....NA.MGqnrndgpG.....QS...........pmPP..PPP........S............TP.........DSSQPG.......D.....KAPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.77|      43|     428|    1521|    1608|       2
---------------------------------------------------------------------------
 1531- 1580 (66.64/96.97)	QLNTSSA.SPADGmRIDDDgkdpphIVLYIVEPFT....CGNDSPDVERLACLSL
 2025- 2072 (68.13/21.11)	QQNQSSTeHPLDS.NITAD......VLRYVLEGYNllswLAMDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.44|      31|     846|     127|     162|       4
---------------------------------------------------------------------------
  128-  158 (55.41/19.29)	IGSLKVRSESSLGAGSGGSIGSG.SGVPMTPS
  961-  992 (47.03/13.48)	VGRSKANALAHLGLSGGGSSSSAfGGMLGSPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.03|      13|      15|     186|     199|       6
---------------------------------------------------------------------------
  186-  199 (21.97/17.72)	LQSLKRPS...LFCkDY
  202-  217 (20.06/10.43)	LQSEDIPStsqLLY.DY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.69|      53|      57|    1100|    1154|       9
---------------------------------------------------------------------------
 1100- 1154 (85.40/52.34)	SLPLTLKVMDLLRE.QCSVVQSSSNSIHRAVNryRGPLFGRGTENG..AVHLLEYVDA
 1159- 1214 (82.29/44.42)	SLALEQGRLQAINEsKMDVDQQSSSGSNGSPG..SGALVKGGTLRGmmNVHKWPFLRA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07932 with Med13 domain of Kingdom Metazoa
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