<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07921

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMGQGPGVGPGVGSIGGPIGGPGGPGVTMQQQALQQQAGGMGQAGPNQMNAGVAMGPGGVVAPSGGGVMGPGPNQMIGAGGAGGPGTGQQGNFVGMGGNTMVRKPPDMMPGGNVYPGSGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPQSHPGQMIPSPALIPSPNPHMGGVAQRSTIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYRALTKYIEPLKRMIAKMENDDIDKIAKMKRLLEILSNPSVRIPLETLHKCEAALTSQLGSIRETPTNNPLVEAVSSSLQGATGNHTLQRTFRPCLEALFGPDIKNLPPPAKQPRLALDDTAAAGGTTGGVTSGGSAATTTSITPAATANSSSNNTIGSATSTTTTCIAAPQEIPHILQGEIARLDQKFKVSLDQCAISGTRTIKLICWLDDKNLPCVPPVAVTIPEDYPFTAPSCSLIEQEYNATPFLILVQKSLMARICKLPGLFTLSHLLDTWEMSVRQACSPNPTIVAPTGTSVLLGM
Length514
PositionTail
OrganismAnopheles christyi
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.190
Instability index50.54
Isoelectric point8.53
Molecular weight52553.46
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07921
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     300.97|      67|      73|       1|      71|       1
---------------------------------------------------------------------------
    1-   38 (43.84/12.63)	........................................MGQGPGvgPGVGSIGGPiGGPGG..PG.VTMQQQALQQQAG
   39-   93 (95.94/27.53)	GMGQAGPNQMNAGVAMGPGGVVAP.SGGGVMGpG..........PN..QMIGA.....GGAGG..PG..TGQQGNFV....
   94-  140 (70.53/16.78)	GMG..GNTMVRKPPDMMPGGNVYPgSGGAVRS...............................vtPN.NFLRQSPSPSVPS
  143-  208 (90.66/23.45)	GPGAHGP.QSHPG.QMIPSPALIP.SPNPHMG.GvaqrstIGQS....PG.GSLNTP.GQPGGavPSpLNPQDEQL.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.47|      13|      15|     220|     232|       2
---------------------------------------------------------------------------
  220-  232 (22.21/18.99)	IEPLKRMIAKMEN
  238-  250 (20.27/16.69)	IAKMKRLLEILSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.94|      36|      96|     271|     309|       4
---------------------------------------------------------------------------
  261-  304 (49.58/27.41)	HKC.EaaltsqLGSIRETPTNNPLVEAVSSSLQGATGNHTlqRTF
  305-  344 (36.81/17.82)	RPClEalfgpdIKNLPPPAKQPRLALDDTAAAGGTTGGVT.....
  347-  376 (39.55/16.37)	............GSAATTTSITPAATANSSS.NNTIGSAT..STT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07921 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MGQGPGVGPGVGSIGGPIGGPGGPGVTMQQQALQQQAGGMGQAGPNQMNAGVAMGPGGVVAPSGGGVMGPGPNQMIGAGGAGGPGTGQQGNFVGMGGNTMVRKPPDMMPGGNVYPGSGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPQSHPGQMIPSPALIPSPNPHMGGVAQRSTIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKY
2) NLPPPAKQPRLALDDTAAAGGTTGGVTSGGSAATTTSITPAATANSSSNNT
1
318
213
368










Molecular Recognition Features






MoRF SequenceStartStop




NANANA