<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07919

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPQPLEQGGAVTSFIPTGQEMAQRQNLIPLGRLIDFIIQRTYHELTVLAELLPRKTDMDRKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMGFLDKQSMLFIDTADMLSRVARETLVHARLPNFHIPAAVEILTTGSYSRLPSVIRDRIVPPDPITPAEKRQTLQRLNQVIQHRLVTGSLLPQLRKFRIENGRVTFKVDHEFEVSLTVMGDAPTVPWRLLDIDFLVEDKETGDGKALVHPLQVNYIHQLIQGRIVDCTDALAEVYTCLHYFCQSLQLEVLYTQTLRLIRDRLDDHIHVDEYVVGSRLTVSYWRELTNKDPKSELGYRLTIQTDPNDAAKQLAILHVPSIGNKEADIADRAVRSDLLSMERLLVHTVYVRSLARLNDVKTELQLFLKDVEYNIQGTPAMLTVPVLNPCLRAEHIYITVDTHTGMLRCHVPKHLDCPIMPEMQHALNNDWSKLQHLISELRYWITQRRCEKTLQHLPAATQDRLPLIYPHTHPIARMGPHKVFIQLYRHANVILIVELKEKKTCPNEMTYTFYLVLVKPSSVEEGQSPDVSNAQSAQSSAAGGLASSNETATAAMPKMYLRVLSMIEFDTFVATHGPGTYIDDTCPASTSGTSIKRKISPLDSALAGMGPPLKQQKTIYPAYFIPELAHVVAMCDEKLPFVTLAKEFTMRKIPHGGLQVEANATSLVLKLLTLPPPKPPQAPPSHQQQQQQQQQQQQQQSGTSDAKSGAAASANEPKTVHVPPIDKQVWNALLKRLLSVSVRAQVNKSNQTRLWTMELVFYGSPLPSLHHKEQGMRRAVYLQYEMQPVESVSKVVDQLLSDWSKIVYLYTLVHEFREQFNNEKYNLPSMVTIKSYSYTNLLLAYGPNKDVSVNICWDTEAKEFRLVFTGGNSAINAHSMMRDQLQAHLNHNYSLAQIVHMLHETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEVRFRGGGLCTIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVFRRRSQSEDDNPPSPVTMEDPSGHGGAGGGSCGGNNGGAGGGGVAGGGSNTFLSGGTGMRGPQSPRDPGLRFAAPLTPPTSSNPHTPASPHPIGGGGGAGGAGGAGGTGGQGGQQQGHMSNFNMTSPPASHMPHPSPGGGLMPSSPLNAQPSPMAAHSPGPSSLSYMQGHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYTSRVLPARSWAGAIPTTLTYEALDTLCRATPHPQKEVPGPELSPLERFLGSVFMRRQLQRIIHQEESLMAITSNEPGVVVFKADCLQYQVFLNPNHMQSLHLKVDQLPMGPMMDVKPPYQWAAQDLQILEQFFDQRVAAPPYRPAVMTSFTRMLNLPARVLKDFIQIMRLDLMPELVQGNKWNVQFVLRVPPSATPIVPVGTTTILSHRQKILFFIQITRVPYLPNMEWKDAVTMLLPMVYDMNMNHTTLAERREPMPPQLTSAVSAHLRRFSECSVLLPDECSLFPAVHDLLLTLTLPNEPPVPGQMQMQLGGVMQPGGGPGGPGGPGGPMGGQIGGSTPQVVPQVGSSPSPMMHSPMQQMGGGGQQPGGYGGMVGGPGGGPQSGGPGGGGPGGPN
Length1647
PositionTail
OrganismAnopheles christyi
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy-0.270
Instability index52.49
Isoelectric point8.52
Molecular weight180844.58
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07919
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     485.55|      64|      65|    1058|    1121|       1
---------------------------------------------------------------------------
  995- 1058 (56.68/16.79)	........GGGLC..TI...RD.GAYSRFDRS.HVVEEF.TPTQGLKGflskyvdetavfrrrSQS.EDDN.....PPSP..VTMEDP
 1059- 1121 (113.32/40.81)	..SGHGGAGGGSC..GG...NNGGAGGGGVAG.GGSNTFLSGGTGMRG...............PQSPRDPGLRFAAPLTP..PTSSNP
 1124- 1188 (102.72/36.32)	PaSPHPIGGGGGA..GG....AGGAGGTGGQG.GQQQGHMS.NFNMTS...............PPASHMPHPSPGGGLMPssPLNAQP
 1190- 1237 (64.70/20.20)	P.MAAHSPGPSSL..SY...MQGHTDGSPFAAlSPAASNWPGSPGMPR...............P.SPR.PG.................
 1549- 1608 (88.75/30.39)	P.NEPPVPGQMQMqlGGvmqPGGGPGGPGGPG.GP....MGGQIG..G...............ST....PQVVPQVGSSP.sPMMHSP
 1611- 1646 (59.39/17.94)	Q.MGGGGQQPGGY..GG...MVGGPGGGPQSG.GPG....GGGPG..G...............P........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.04|      40|      66|     314|     355|       2
---------------------------------------------------------------------------
  314-  355 (65.35/48.84)	RLTVS..YWRELTN.KDPKSELgyRLTIQTDPNDAAKQLAILHVP
  378-  420 (59.69/37.33)	RLLVHtvYVRSLARlNDVKTEL..QLFLKDVEYNIQGTPAMLTVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     350.94|      96|     480|     878|     977|       3
---------------------------------------------------------------------------
  878-  977 (155.75/113.57)	LAYGPNKDVSVNICWdtEAKEFRLV..FTGGNSAinAHSMMRDQLQAHLNHNYSLAQIVHMLHETYQPLSSIAKLPIIPHLAILQSPK........IPVLSFCIIPQSPT
 1303- 1354 (58.59/31.65)	.......................................FMRRQLQRIIHQEESLMAI.....TSNEPGVVVFKADCLQYQVFLNPNH........MQSLHLKV......
 1357- 1453 (136.60/88.05)	LPMGPMMDVKPPYQW..AAQDLQILeqFFDQRVA..APP.YRPAVMT......SFTRMLNLPARVLKDFIQIMRLDLMPEL..VQGNKwnvqfvlrVPPSATPIVPVGTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.86|      40|     480|     116|     161|       4
---------------------------------------------------------------------------
  116-  161 (61.67/51.35)	LSRVARETLVHARLPNFHIPAAVEILTTGsysrlpSVIRDRIVPPD
  599-  638 (71.18/44.83)	LSMIEFDTFVATHGPGTYIDDTCPASTSG......TSIKRKISPLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.51|      12|      42|     712|     723|       5
---------------------------------------------------------------------------
  712-  723 (25.32/12.23)	PKPPQAPPSHQQ
  752-  763 (23.19/10.50)	PKTVHVPPIDKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.96|      27|      42|     801|     828|       6
---------------------------------------------------------------------------
  801-  828 (43.99/38.44)	LPSLHH..KEQgMRRAVYLQYEMQPVESVS
  844-  872 (42.97/31.29)	LYTLVHefREQ.FNNEKYNLPSMVTIKSYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.98|      21|     314|     163|     183|      12
---------------------------------------------------------------------------
  163-  183 (36.41/21.75)	ITPAEKRQTLQRLNQVIQHRL
  480-  500 (37.57/22.68)	ITQRRCEKTLQHLPAATQDRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07919 with Med14 domain of Kingdom Metazoa
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