<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07917

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSADLRIVKLFEEVVRYKLANDECLSTLQEDKNVVPNLDEEEQRKKTEEGYKKIGTLFGAMTPESKEASIRNYLGYVASVNHQIRVHNYLQVMNRMVALNIIPAKLLCDQLMCSDKLVYKNPCFWIEAFRLIRKVIGGVDYKGVREIMKCCKEKAHSFPANVSVNILPQLLELIELIEHIFNRNACLLPAYFIINEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSIIGHSSMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDEELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMECSEKEATQGGQSAAGGTAMNEHDGDQSHTQWIWLHLSSQLIYFVLFQFATFQNIVNTLHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPILKLYDILYPEKEPLPVPDNNNPNCTHQMAPTCIWIHLMKRAQTENYNINRPIPIALRLHFEYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMVGGGQPLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSQAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYVSEPKPPGNIVSGESEELNRALILTLARSMHITGTGNDPQSSAWCKDLLQNIMVNTPHAWPQHTLYCFPPVLNEFFMQHIIPKESKQLLKKTVDEEYRNWASMTNENDIIAHFGMTVNPPLFLCLVFKMIIETDVISPVAYKILERIGARALSTHLRKMCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIITIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTTEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPSLPVYFGNVCLRFLPVLDIIVHRYLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGTVVGSLKDVRPENWALTEAYQAYMMTKESDNVNWVPELTMDGKNIFSGTDWRFNEFPNPPAHALYVTCVELLGLPVGPNVVANSIIDVLVKGYPVVPNGVIHNWANTIGLIMSALPEAYWSVIYERMQEALNSKAMKEWTYRQSPFDMFNFKIVKEAMLDRSYVTVLAIVHSTFHHFGIGQLATITDSIKEKLKPLVHTEYQLIYLCHVVGPFLHRLSIERARAVGDITLMLYELLEQVDKAQPAQPLRYMDPICDLLYHIKYMFVGDTMKTELEAIIRRLRPALQMRLRFITRLNVEEIGVDQNAAAVAAVAQGGANSGTTGTATGVVAPGVPGVTQGGVATGQVAPGTAGGPQQTPQVGGVVNQNVALQQQLQQQQMGQGIQSHH
Length1441
PositionTail
OrganismAnopheles christyi
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.09
Grand average of hydropathy-0.110
Instability index45.26
Isoelectric point7.34
Molecular weight164086.21
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07917
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     826.16|     270|     329|     686|    1014|       1
---------------------------------------------------------------------------
  701- 1014 (427.54/444.72)	YVSEPKPPGNIVSG.........ESEELNRALILTlarsmhITGTGNDPQSSAWC.KDLLQNIMVNTPH...AW.PQHTL...YCFPPV...LNEFfmqhiiPKESKQLLKKTvdeeyrnwasmtnendIIAHFGMTVNPPLFLCLVFKMIIETDVISP..VAYKILERIG..ARALSTHLRKMCDYLLFEVANSGG...GAHVNKCVDTINDMIWKYNIitIDR...LVLCLILRTLDgneaqvSFYIIQLLLLkTTEFRNRVQEFITINSP....EHWKQNNWH....ERHLAFHQKFPEKFAPDESV..SHPSLPvyfgnvcLRFL.PVLDIIVH.RYLEVPTQLSKTLDVIL
 1021- 1332 (398.62/292.29)	YKFHDRPITYLYNTlhyyerklrDRPQLKKRLVGT......VVGSLKDVRPENWAlTEAYQAYMMTKESdnvNWvPELTMdgkNIFSGTdwrFNEF......PNPPAHALYVT................CVELLGLPVGPNVVANSIIDVLVKGYPVVPngVIHNWANTIGliMSALPEAYWSVIYERMQEALNSKAmkeWTYRQSPFDMFNFKIVKEAM..LDRsyvTVLAIVHSTFH......HFGIGQLATI.TDSIKEKLKPLVHTEYQliylCHVVGPFLHrlsiERARAVGDITLMLYELLEQVdkAQPAQP.......LRYMdPICDLLYHiKYMFVGDTMKTELEAII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.94|      44|      47|     144|     189|       2
---------------------------------------------------------------------------
  144-  189 (69.26/47.95)	VREIMKCCKEKAHSFPANVSVNILPQLLELIELIEHIfnRNACLLP
  194-  237 (74.68/45.37)	INEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSII..GHSSMLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     177.48|      46|      52|     397|     443|       5
---------------------------------------------------------------------------
  397-  438 (68.51/37.78)	...........HLM.....WVFLQYISGSIQKHSILNFLPI.LKLYD.ILYPEKEPLPVP
  440-  490 (60.97/34.40)	NNNP....nctHQMaptciWIHLMK.RAQTENYNINRPIPIaLRLH....FEYLQHLAMP
  491-  536 (47.99/21.59)	SNNPtlfmgseYRF.....ALLCNAYSTQTDYFS....RPM.QALIDtILGNSKNP....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.48|      16|      16|    1377|    1392|       7
---------------------------------------------------------------------------
 1377- 1392 (30.31/20.82)	GTATGVVAPGVPGVTQ
 1394- 1409 (31.17/21.64)	GVATGQVAPGTAGGPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07917 with Med23 domain of Kingdom Metazoa
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