<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07912

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSSGATAISGGSLPALLMANGGSGGSGGPGGVGVGKGIGKPDIKPPVGPTVGGTGTTGKVLLGGDKHETWQMELLMERLRSKAKSAQYKSFPEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSLQHFSDVHSQLLKAPLGVVQKRRGGHPMRLTYFVTPYELLDLGTRTMHALSAELIAKERIGCSVAVVLEASSANKLQIQPLLVVNGSGSAAFVGQPVYTPIEKHNSTSLPATFVLRLSKPMPINSAMMRAIKGIVGGSGAGEQQQAGEGSSGGLPGSLLGLIAHHASGGSVADLTKGLLVSLPDQYHCYYLTDNPSLRGVMVSSIAFTEPQHVPKILTYLRQQAVFNQLLSSCIRTNTPAANGGRPSALQMLLDGGVHTIESGSTGGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIANIAVRIYCSEGETSDDHTLERISGVLQRCMSIPVTLRALMKLWEEEHEQKFKPNLLGSSTVSSSGAGGGPGGGGTGGAAPGLNNGGDGTGPGSALTGSGEDGTMNGFNLSSLGGPGTTVDGAGVGGGGGSAATNGTSAQQTGQRGLLNGEGNGLTVSGGNLGLDFCDMLTERNGNGMGMVGLGAGGRTTGGLGVREPPEQLAGGAAKKRRMEDFCKSPKSDSNLSVGGGGGSDNVGVEKANVTAGIDGATITTVTSQDVGAAIATSGGTAGNSEQRMQIGGATEEDTGGLPLFGETAPASGADAKGSSLGGTTTNMMISAKNEPPSVLPCDDDTGLAGVKMPLQSSSSSSLSSLSSSGFSVAAAPSGESALDRPCPGTLLLESLDFSALETDTAKRTTIGQPSKRRRSSSSSSSSSSSSSSSSSSSSSTSGASDDLEESVDLVEAEMNSFFAEGNNTQPVATTAKGSFGSPSGKPALGTVSPICGKVVSPSGAAGGLEKPLSTINSAGLEIIPLTTTAATISASGFPSTAAISTPLPVAQSNATSGTSSTSTSSSTTKKSSSSSSSGHRKGTDSSDRSSLSKSEKKKKRKADDSGHHAMGPPNKLPFKSGESSPHRSGIGGSSLSTSKSSPKHSSPVHHSSPKHTGSGALGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGTKSSDLSGGGASGTSISTTSSSSKERDKDRSEKKALQFSTTNTSTGSSLTSNSASGSSSSSSSGGRSKNSSLKLKQLDLAAGSSMTISMAGIGDAGSSSPVAPMIDLTGSIPGSSLGALGLPGPGMTTASSMLQVLQAAKNRKPPSSASNSGLGGSLSAVIDKLKSAQSADDEAVLVLPEMTITQQTTSTPIAAGSGGIAVGVNIGGFGALKDPSKSGNSVLSTGGSGALSNCVSSTGGIGAAITQSSSMTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSNKSSSNSGGGSKSSNKSGLKSGVSSGPVSSKQQQSNHTTSFSGAFPSSTKSPHYTSSTSGSSKMPFQKSNSFGSLGGGGTGLKASKVSSPKSTSNPASSSSSAYSSKEKGGATSGRSKSSSASSLTGAMVTGVAGAATGTGSSALVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNNSSAGSAATGQNDSNEAGTKGVKDAGARKQKQQPPGVSSAQSVGSSSIRQFSSSPSGEASARLLSDLLGAAAKSGNKMAPGTSGTSVDGAGGAGLHPLLPNIVQKMFGSDGALQTKSNSSDGSMFPTAGRASPGMLSGSASRDGFRSGGSGSAPGTPTTTGSMVLPPFPSPVSGGASNDGDVGSGGGTLMRPPSRPSSTISNHSHSSQDGIGGGANNSGDAAGTPSVTSMALMINAMSAVAGGQSPASGSLPLDSTSTQQLIAALAAKSGATAGGVLPPPNNLLNNHHHHHSNHLNNHIVGGAAALNNLPSPASVSVHLVKSPAPSPLPFASPHSNASSTLGATGAGGLDDDLMDEALIGIGSK
Length2087
PositionMiddle
OrganismAnopheles christyi
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.271
Instability index48.92
Isoelectric point9.04
Molecular weight208008.82
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07912
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     500.80|      61|      61|     622|     682|       1
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  599-  654 (90.82/24.33)	EEEHEQKFKPNLLG.......S..STVSSS...GAGGG.................PGGGGTGG...AAPGL..............NN....GGDG...T......GPGSA...LT.GSG
  655-  713 (80.54/20.53)	EDGTMNGFNLSSLG.......GPGTTVDGAGVGGGGGS.................AATNGTSAqqtGQRGL..............LN.......G...E......GNG.....LT.VSG
  714-  761 (48.65/ 8.74)	..GNL.GLDFCDM..........LTERNGNGMGMVGLG.................AGGRTTGG...L..GV..............RE...................PPEQ...LAgGAA
 1204- 1260 (56.28/11.57)	A...L.GFHSPKHG.......SSVSPKHP.......LH.................SGGSSTGG...GKPSM..............SAlksaAASG...S......SPGTKssdLS.GGG
 1318- 1381 (56.61/11.69)	KNSSLKLKQLDLAA.......GSSMTISMAGIGDAGSS.............spvaPMIDLTGS....IPG................S....SLGAlglP......GPGMT...TA..SS
 1514- 1597 (46.88/ 8.09)	KASEYMVKP.SSDGikltiqnKKGSNKSSSNSG..GGS.................KSSNK.SG...LKSGVssgpvsskqqqsnhTT....SFSG...AfpsstkSPHYT...SS.TSG
 1832- 1885 (73.92/18.08)	SDGALQTKSNSSDG.......SMFPTAGRASPGMLSGS.................A.SRD.........GF..............RS....GGSG...S......APGTP...TT.TGS
 1886- 1949 (47.11/ 8.17)	M..VLPPFPSPVSG.......GASN..DG.DVGSGGGTlmrppsrpsstisnhshSSQDGIG....G..GA..............NN....SGDA...A......GTPS..........
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     301.98|      42|      44|    1726|    1767|       2
---------------------------------------------------------------------------
 1036- 1078 (35.26/ 6.27)	SPI.CG.................KVVSPSG..AAGGLEKP.....LSTI..NS......AGleiipltTTAATISA
 1079- 1120 (46.37/11.15)	SGF.PST................AAISTPL..PVAQSNATSGTSSTSTS..SS......TT.......KKSSSSSS
 1121- 1183 (35.11/ 6.21)	SGHrKGTdssdrsslsksekkkkRKADDSGhhAMGPPNKLPFKSGESSPhrSG......IG.......GSSLSTSK
 1272- 1312 (43.09/ 9.71)	SSK.ERD................KDRSEKK..AL.QFSTTNTSTGSSLT..SN......SA.......SGSSSSSS
 1606- 1642 (47.67/11.72)	SNS.FGS................LG...GG..GTGLK..ASKVSSPKST..SN......PA.......SSSSSAYS
 1643- 1679 (37.47/ 7.24)	SKE.KG.......................G..ATSGRSKS...SSASSL..TGamvtgvAG........AATGTGS
 1737- 1778 (57.01/15.83)	SNE.AGT................KGVKDAG..ARKQKQQPPGVSSAQSV..GS......SS.......IRQFSSSP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.76|      39|      42|     798|     839|       4
---------------------------------------------------------------------------
  775-  827 (47.10/23.03)	SDSNLSVGGGGgsdnvgvekanvTAGID..GAtiTTVTSQDVGAAIATSGGTAGN
  828-  866 (47.29/19.94)	SEQRMQIGGAT.........eedTGGLPlfGE.....TAPASGA..DAKGSSLGG
 1449- 1479 (41.38/15.02)	....IAVGVN.............IGGF...G...ALKDPSKSGNSVLSTGGS.GA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.84|      25|      43|    2001|    2025|       5
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 2001- 2025 (48.96/25.01)	PPPNNL..............LNNHHHHHSNHLNNHIVGG
 2033- 2071 (34.88/15.40)	PSPASVsvhlvkspapsplpFASPHSNASSTLGATGAGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.62|      32|     544|    1406|    1447|       7
---------------------------------------------------------------------------
  985- 1024 (35.46/12.08)	SGASDDlEESVdLVEAEMNsfFAEGNNTQPVATTAkgsfG
 1416- 1447 (54.15/43.54)	SAQSAD.DEAV.LVLPEMT..ITQQTTSTPIAAGS....G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.25|      35|     121|     242|     276|       9
---------------------------------------------------------------------------
  242-  276 (59.59/37.31)	TDLHTLYTLSLQHFSDVHSQLLKAPLGVVQKRRGG
  358-  392 (59.66/37.37)	TSLPATFVLRLSKPMPINSAMMRAIKGIVGGSGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.53|      34|     390|      10|      43|      11
---------------------------------------------------------------------------
   10-   43 (62.21/24.34)	SGGSLPALLMANGGSGGSGGP.GGVGVGKGIGKPD
  401-  435 (54.32/20.16)	SSGGLPGSLLGLIAHHASGGSvADLTKGLLVSLPD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07912 with Med1 domain of Kingdom Metazoa
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