<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07908

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDTWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMKDLIPKLHEHYHQGPLQEKPSAGGGGSSGSLSSAASGLGLSSGAGGTNVSTIPPPLSSPAGSMHSPASGNAVVGGSMHSQQQQQQHQPISPQEEQRIAQKQWNYSTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLHDLVQSERFCRRLAYAVSKKLAQLINQMAESHNINLSSPAECLDGNGKQTSIEMSESKPDKPNDKPLKEGTAGTATQPADTKPPKVNPYEMIFTEYLHCSHHRDVVLQLSSILQVITLECPTALVWCGVGETRSSSVLSGSPLDHLPVAPSALPMPSRYEKSNEDIRRQLFEAEESIKVRSRHAESRWCIDKWQTAAGNASLKILATLDALDGHCFDRMDSNNSLDSLYSKIFPPFQVQQIKPTESASGGSSGGSGQGNIAVGVSATDGKDAATKQFEYNVEQDSSIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVLTALENDSYTNNLNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLDEAGSTQNKSQFTNLVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDSHGICNAGLGTGPISNKPATSSSPNNGGGVEEDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPSVTGLGKAESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFESTSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAIGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVELQLIGKSSMALVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKSRPQQEPFHNAYPKIKQALYTPLQPTPSAHTYNPQFMIDIITNPRRGGKIESAWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHKVSSIFGTGKRSGLNTPVHPGSTPKSMAGSGDLSHILGTSDLSILGNPDESMLDVSMIELGELSPTASARLYSSRQQNSHLNQDNATSLSDFAQHVLRQICSQEWVLERCLQHAEELCQHGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELDQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCSSPDLSNWLDMVARAAIDVFRVNEFILNSPDVKQEKVKPSTWLVAPLVSKLPSAVQGRILKVSGQVLESTSMFSKHKDGNGGNNSSNNNSHNHGANSNSSVSSNGSSFGSKQSSQLNHQPFLGLVLTCLKGQDEQKEGLLQSLYSQLSQFLQNRDQSLETIGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVLTCDSAGSSTDAKGNKIAIDSIEKKNGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEVDPLPDKLKDDMKADTPSSDQSPAPSTGSKKGKTNRKRKKPAAAAQVQQSQPQQPIMPAIVSQPTAGPQQMQQMQQQQQQQQQQQQQQQQQQQQQMQQQQTLQQQQHLQQQQQQLHLQQQQAQQQQQLQQQQQLQQLQQQQQQQLQQQQQQQNQMMMQQQQQPNIPQQQQSTMQQQQLSSQQAQQQQVSMTPQQTLQQMQNNNMGGMQMGGPMNSMSQQHMQQQYGQANPAQLVGQGNMGGMQAGMVGLGAGMGGGMMNQQQQQQQPPQQQQPQQAQQAQQTQQAQQQQQPQSNPNMGFVGNVNPMAQLAQQQGANQQWGGYASMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQSQAQQQQQTPQQGPQASQQQGAQQGPQQGSQQGPQTQQQLQQQQQQQQMFYSGMGQATMNRFDRPQLNTNSKQALSNMLRSKLPINAGHPASFMQQQQQAQRNPQQPFLRGPLRAGMPGNPIVGAQTGMGPINPAMAGGTAGIGTAGGGAVMGTQGMSAGGMMAAQQSAQGQQSTGGIMNQNTPAMMGTTGGSIMGQSGGSMIQTGMMNSQQNPALVGQGMGGSGGIGGGGGMAGNSGMGGSAGGMGGSSGGMVTSGGMVTAGMGSAGIGNTTPMGGGQGGGMGGNSGMPNAAGMGNPSMGNPGLGMQNMQQAGNMQGGMFQGQNVPYQNVNQKYPNYGNQSMGQQSGQGGGMMGNFNPMAQQQRNTQAEFIAQQRAAMAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNMPQNQQQQFQQQRMRLIMQQHSGMGQGGNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
Length2790
PositionKinase
OrganismAnopheles christyi
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.610
Instability index55.48
Isoelectric point6.90
Molecular weight305407.12
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07908
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     599.29|      46|      47|    2012|    2057|       1
---------------------------------------------------------------------------
 2017- 2064 (85.29/21.11)	QQQQQQQ...QQ.....QQQQ..................QQQ....M......QQ.............Q.......QTLQQQQH...........LQQQQQQLHL.......Q..QQqaQQQQQ
 2066- 2107 (71.19/16.42)	QQQQQLQ...QL.....QQQQ..................QQQ....L......QQ.............Q.......QQQQNQMM...........MQQQ.............Q..QPniPQQQQ
 2108- 2166 (59.27/12.47)	STMQQQQlssQQ.....AQQQ..................QVS....M......TP.............Q.......QTLQQMQNnnmggmqmggpMNSMSQQ.HM.......Q..QQ..YGQAN
 2167- 2213 (69.00/15.70)	PAQLVGQ...GN.....MGGM..................QAG....M.....vGL.............G.......AGMGGGMM...........NQQQQQQQPP.......Q..QQ..QPQQA
 2214- 2269 (69.75/15.95)	QQAQQTQ...QA.....QQQQ..................QPQsnpnMgfvgnvNP.............M.......AQLAQQQG...........ANQQWGGYAS.......M..QQ..QQQQQ
 2270- 2299 (60.20/12.77)	QQQQQQQ...QQ.....QQQQ..................QQ............QQ.............Q.......Q..QQQ..............QQTQ....................SQAQ
 2300- 2341 (44.51/ 7.56)	QQQQTPQ...QG.....PQAS..................QQQ....G......AQ.............QgpqqgsqQGPQTQQQ...........LQQQQQQ......................
 2390- 2466 (55.27/11.14)	QQQQQAQ...RN.....PQQPflrgplragmpgnpivgaQTG....M......GPinpamaggtagigT.......AGGGAVMG...........TQGMSAGGMM.......A..AQ..QSAQG
 2467- 2508 (42.46/ 6.88)	QQ..........stggiMNQN..................TPA....M.......M.............G.......TTGGSIMG..............QSGGSMI.......QtgMM..NSQQN
 2622- 2664 (42.35/ 6.85)	.....PY...QN.....VNQK..................YPN....Y......G.........................NQSMG...........QQSGQGGGMMgnfnpmaQ..QQ..RNTQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     198.98|      23|      23|    2515|    2537|       2
---------------------------------------------------------------------------
 2515- 2537 (49.14/20.08)	G......MGG.SGGIGGGG...GMAGNSGMGGS
 2540- 2557 (25.99/ 6.51)	G......MGGsSGGMVTSG...GMV......TA
 2589- 2603 (27.11/ 7.16)	G......MGN.PSM...........GNPGLGMQ
 2677- 2696 (30.40/ 9.10)	G......RGQ.YGQHAPNV...TM.GN..MGVN
 2705- 2725 (33.41/10.86)	R......QGG.KPGV..GG...NMPQNQQQQFQ
 2726- 2757 (32.93/10.58)	QqrmrliMQQ.HSGMGQGGnaqGMMQNQGQGMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.71|      19|      25|    1944|    1962|       5
---------------------------------------------------------------------------
 1944- 1962 (33.38/16.20)	KLKDDMKADTPSSD...QSPAP
 1968- 1989 (27.33/11.86)	KGKTNRKRKKPAAAaqvQQSQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07908 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGMGSAGIGNTTPMGGGQGGGMGGNSGMPNAAGMGNPSMGNPGLGMQNMQQAGNMQGGMFQGQNVPYQNVNQKYPNYGNQSMGQQSGQGGGMMGNFNPMAQQQRNTQAEFIAQQRAAMAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNMPQNQQQQFQQQRMRLIMQQHSGMGQGGNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
2) DLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPSVTGL
3) GKQTSIEMSESKPDKPNDKPLKEGTAGTATQPADTKPPK
4) HEHYHQGPLQEKPSAGGGGSSGSLSSAASG
5) LGTGPISNKPATSSSPNNGGGVEEDVLQTDF
6) LPLPPEEVDPLPDKLKDDMKADTPSSDQSPAPSTGSKKGKTNRKRKKPAAAAQVQQSQPQQPIMPAIVSQPTAGPQQMQQMQQQQQQQQQQQQQQQQQQQQQMQQQQTLQ
7) LSSQQAQQQQVSMTPQQTLQQMQNNNMGGMQMGGPMNSMSQQHMQQQYGQANPAQLVGQGNMGGMQAGMVGLGAGMGGGMMNQQQQQQQPPQQQQPQQAQQAQQTQQAQQQQQPQSNPNMGFVGNVNPMAQLAQQQGANQQWGGYASMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQSQAQQQQQTPQQGPQASQQQGAQQGPQQGSQQGPQTQQQLQQQQQQQQMFYSGMGQATMNRFDRPQLNTNSKQALSNMLRSKLPINAGHPASFMQQQQQAQRNPQQPFLRGPLRAGMPGNPIVGAQTGMGPINPAMAGGTAGIGTAGGGAVM
8) MFSKHKDGNGGNNSSNNNSHNHGANSNSSVSSNGSSFG
9) MNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKH
10) SGAGGTNVSTIPPPLSSPAGSMHSPASGNAVVGGSMHSQQQQQQHQPISPQEEQRI
11) TQGMSAGGMMAAQQSAQGQQSTGGIMNQNTPAMMGTTGGSIMGQSGGSMIQTGMMNSQQNPALVGQGMGGS
2557
820
389
194
775
1931
2115
1622
1
228
2449
2790
855
427
223
805
2040
2447
1659
35
283
2519










Molecular Recognition Features






MoRF SequenceStartStop




1) KRKKPAAA
2) NMRPLKRPRLGP
1974
2
1981
13