<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07903

Description Uncharacterized protein
SequenceMALVTNPYAVSTSPHSSYSDDGNTEDEEAAKVNQSRLNECHKGTATLMLGSNKRLRASCEEQHLNNPGTNDSIGSSSRTQQPIGCPDVSAPNTDGARGDSFEGEECGDITGDAGDDSGDGGGAGAGGDKLVPYASRPASSCSSGSCSSSSEIQQHLQSMFALLRPEETLKMAVKLESLRPGRTRYLVVVSRSVSSKRHSTCTLLLPAGSSGNLNSLSWPSASASLQSSRAGSVLSGPTVQPTARLGSVVTPVDLGGALGVDTFVSSLEHCLLSSSSSSSSSSNSSNSNSSSTAAAAAAQQSSLSRLSAPVERLVPCGNDECDSKTNTRLSSNNISAAEADCTAAAGTFDDASALDVPNGVGSSSLGQQQQQQQHFQQSSYAGGNEVVGGSGGTGIAADSGKEIEESCLLGIDCNERTTVGLVLKVLADTSIRLDGDGGFSVSSCGKQHIFKPVSVQAMWSALQTLHKFSSKAREHNFFAGGPSHDWVTYYETHIDSDRSCLNEWNAMDSLESRRPPSPGSIRSKPTKREETESVIRSKLKEVMMSVDLDDVTSKFIRGRLEELLDMDLGEYKPFIDGEMLVILGQMDAPTEIFDHVYLGSEWNASNLEELQRNGVRHILNVTREIDNFFPGLFNYFNVRVYDDEKTDLLRHWDNTFKYISRAKMEGSKVLVHCKMGISRSASVVIAYAMKANNWDFQQALQHVKEKRNCIKPNKNFLMQLETYQGMLDAMKNKEKLQRSKSETNLKLAGAKEGRSLPGSEPTPLIQALSGATGGGQGAAGGKRHTVGGVAGAQLPHKLDATGGGSAFSGPSKTADDLDVLDGGAEAHALALGLAADGDGVETSQGSRGRSRTRQHKHPHQQHQPKEEPLQHEHHQQQQQQQQHQQQQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQHHQQQQEQQKQQQQHHQQQQEQQKQQQQQQLQQQQQHQQQQEQQKQQAPNTHRQHTARPSFCESWQGILSHSGAWAEGNQRARPQTCASGAASSSSPSTRAVKRHKSLSPDTLHPRWVSSHEAATLAASLGLPEPAEPVALVDRGASEPRASRRKQQSYSLEHLHGLLEMRSPCAETKTIRMPCGNGQNYSVSPNQIVHLQDKLPKASGRDASGGSSLSSSSSGAARTGSFLRRIFPSHYDTSASSAAIPAGEATALGMVAGDSPATAGSSLTQCSTAASSKTTSTLTTVPSASSSAPPPPSSASSSVGAAAQLPSISSVKTIVCELELSTSGSSSNRSGHIPVAPPPSADSGVVNAAGSSAAIPIASIAAEAAAVAAASANRDVFRKEHASYTSSSSSPSHHELPICWTSSAQIIQQTSTTSMSSYAVSERQTHMTGKPAAEEPNKRVVEEERDVARDVEKEKCSGAGHRGEAERCDDAVAQPQHNDGERDAACPVADGARDALASTKQEQQQQLEQGSTETTGSTCVHSLAPSRPRSCGTLEPSGDSLAQSKPTNDEPQSARAGSVGVQRRTGVTDGGSCFLADRTEDIPWHPGTVRRTKEKIEERSSQKASVAGGGHVTSSLKRTGSSCSTELAADTLTVGSSLKVSSTAAVSSSGGTGSCTVSSAEEAREPATVPSSPTQEQNPTNQTGLPATTADAGGPLQHSSSSVHRGRRGMVSTNYARLSASAPDSYNMYAGPGPARATAATGPRPTVAADTPATSQTGTADGTMQQLVRFRTSIHGRASISVGCGGGAERRQQGGDQQSEQAGDTLNQPGKVRNLKMSFEAKSHDRRREQKKVRSLPSSPVAVHAQMTGQPRAKPQSPVQEQQPPGGPPSKAATLVRQPSTSSLTSQQHAAGSPLEDVTVRDLVDRYEVHGPRARTSSNGGTSISTSTSTSTTTVAIAPSVSRQRPRSVFEPLKSATGGAPSQPSSSSGLLFHTGKTIPHLLSHATAPFRLEEFSRPPVPPVVPLVRGLVNPPIAAVDATSSHLPNLNNNGAAAYNQPYARPGAPTATNNNARNNNMSSDAAVADGSSRKRAQQHGRTHPLAKISPSSNANKHQQQQQQQQQQQEQQQQQQQCHHHHHHHHHHHHHQYAGIGGQLQPHRLATGLVAPAQTAAVSGGAPTGTTAAANVYNTM
Length2096
PositionKinase
OrganismAnopheles atroparvus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.718
Instability index65.37
Isoelectric point7.43
Molecular weight222112.11
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
actin binding	GO:0003779	IEA:InterPro
protein serine phosphatase activity	GO:0106306	IEA:UniProtKB-EC
protein threonine phosphatase activity	GO:0106307	IEA:UniProtKB-EC
protein tyrosine phosphatase activity	GO:0004725	IEA:InterPro
protein tyrosine/serine/threonine phosphatase activity	GO:0008138	IEA:InterPro

GO - Biological Process
negative regulation of actin filament polymerization	GO:0030837	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07903
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     294.16|      19|      19|     875|     893|       1
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  854-  872 (33.15/12.39)	QHKHPHQQHQPK.....EE.PLQHE
  875-  893 (45.33/19.70)	QQQQQQQQHQQQ.....QQ.PQQQQ
  896-  914 (43.37/18.52)	QQQQQQQQQQQQ.....QQ.QQQQQ
  915-  933 (44.05/18.93)	QQHHQQQQEQQK.....QQ.QQHHQ
  934-  949 (34.57/13.24)	QQQEQQKQ.QQQ.....QQ.LQ..Q
  950-  966 (26.70/ 8.52)	QQQHQQQQEQQK.....QQaPN...
 2022- 2040 (44.15/18.99)	QQQQQQQQEQQQ.....QQ.QQCHH
 2041- 2063 (22.85/ 6.21)	HHHHHHHHHHHQyagigGQ.LQPH.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.43|      17|      19|    1762|    1779|       2
---------------------------------------------------------------------------
 1762- 1779 (27.11/14.52)	PSSPVAvHAQMTGQPRAK
 1780- 1796 (32.32/14.15)	PQSPVQ.EQQPPGGPPSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.17|      18|      19|     736|     753|       3
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  736-  753 (28.51/15.89)	LQRSKSETNLK.LAGAKEG
  756-  774 (28.62/15.98)	LPGSEPTPLIQaLSGATGG
 1871- 1884 (22.04/10.35)	.PRSVFEP....LKSATGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.13|      17|      19|     531|     548|       4
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  531-  548 (23.98/27.92)	TESVIRSKLKEvMMSVDL
  552-  568 (29.15/27.00)	TSKFIRGRLEE.LLDMDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.40|      11|      19|    1435|    1453|       5
---------------------------------------------------------------------------
 1435- 1449 (15.73/ 6.70)	GSTETTGstcvHSLA
 1457- 1467 (19.67/ 7.03)	GTLEPSG....DSLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      94.80|      19|      19|    1248|    1266|       6
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 1132- 1145 (20.58/ 6.06)	SS...........LSSSSSGAA......RTG
 1218- 1234 (24.53/ 8.91)	SS...........ASSSVGAAAQ.LP..SIS
 1235- 1264 (25.52/ 9.62)	SVktivcelelstSGSSSNRSGH.IPVAPPP
 1306- 1327 (24.17/ 8.65)	HA.........syTSSSSSPSHHeLPICWTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.05|      26|      47|    1899|    1925|       7
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 1899- 1925 (43.30/32.59)	TGKTIPHLLSHATAPFRlEEFSRPPVP
 1945- 1970 (47.76/31.35)	TSSHLPNLNNNGAAAYN.QPYARPGAP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     139.26|      29|      47|    1592|    1620|       8
---------------------------------------------------------------------------
 1537- 1557 (25.87/ 7.60)	.VTS....S...........LKRTGSSCST....ELA....ADTL
 1558- 1592 (28.76/ 9.36)	TVGSslkvSS....TAAVSSSGGTG..SCTvssaEEA....REPA
 1593- 1621 (51.58/23.32)	TVPS....SP....TQEQNPTNQTGLPATT....ADA....GGPL
 1622- 1658 (33.06/11.99)	QHSS....SSvhrgRRGMVSTNYARLSASA....PDSynmyAGPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.13|      15|      48|    1016|    1030|       9
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 1016- 1030 (26.87/12.44)	RAVKR.HKSLSPDTLH
 1066- 1081 (20.26/ 7.53)	RASRRkQQSYSLEHLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      15|      47|    1805|    1819|      10
---------------------------------------------------------------------------
 1805- 1819 (26.86/14.48)	STSSLTSQQHAAGSP
 1850- 1864 (25.30/13.12)	STSTSTSTTTVAIAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.32|      21|      48|    1351|    1371|      11
---------------------------------------------------------------------------
 1351- 1371 (36.07/19.80)	HMTGKPAAEEPNKRVVEEERD
 1374- 1392 (24.84/11.18)	RDVEKEKCSGAGHR.GEAER.
 1402- 1419 (30.42/15.46)	HNDGERDAACP...VADGARD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.02|      13|     571|     225|     237|      12
---------------------------------------------------------------------------
  225-  237 (23.55/ 9.81)	LQSSRAGSVLSGP
  798-  810 (24.47/10.50)	LDATGGGSAFSGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.01|      10|      32|    1047|    1056|      13
---------------------------------------------------------------------------
 1047- 1056 (19.22/10.18)	GLPEPAEPVA
 1082- 1091 (19.79/10.73)	GLLEMRSPCA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.84|      14|      26|     973|     988|      15
---------------------------------------------------------------------------
  973-  988 (23.20/22.13)	ARPSFCESwqGILSHS
  998- 1011 (26.64/15.56)	ARPQTCAS..GAASSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.27|      12|      19|    1729|    1740|      24
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 1729- 1740 (21.18/14.47)	DTLNQPGKVRNL
 1750- 1761 (20.09/13.28)	DRRREQKKVRSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.16|      11|      26|     696|     706|      25
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  696-  706 (19.03/11.25)	FQQALQHVKEK
  723-  733 (20.13/12.34)	YQGMLDAMKNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.23|      12|      15|    1989|    2000|      28
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 1989- 2000 (20.74/12.98)	ADGSSRKRAQQH
 2007- 2018 (20.49/12.70)	AKISPSSNANKH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07903 with Med12 domain of Kingdom Metazoa
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