<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07901

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDTWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMKDLVPKLHEHYHQGPLQEKSASGVSGSSGGLSGGGGGGLGMGSSASSANPSTIPPPLSSPAGSMHSPAGGSAGVGSMHPQQQQQLPPISPQEEQRIAQKQWNYSTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKASPNADDGLLRIYLPLAMQYLYDFVQSERFCRRLSYAVSKKLAQLINQMADSHNINLNSTDLEPGCKSSMETQDGKDKTLEKPSKDSPSGGAAPHGVDGKPARANPFEMIFAEYLHCSHHRDLVLQLATVLQVITLECPTALVWCGVGDTRSSSVFSGSPLDHLPVAPSALPMPARYEKSNEDIRRQLFEAEESIKVRSRHAESRWCIDKWQTAAGNASLKILATLDALDGHCFDRLDSNNSLDSLYSKIFPPFQVQPIKPTESSTTGGNGKASQGGGQSGTTGADGKDAATKQLEYNVEQDASIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVLTALENDSYSNNLNNSDDKDSMLSGSGLNGGQPVFQHILMNFLDNDAPVLEESGGAQNKSQFTNLVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDSQGICNAGLGTGPISNKPTNTSSPHNATGMDEDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEQAAPSVAGLGKAESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFEATSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAIGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVEQQLIGKSSMALVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKSRPQQEPFHNAYPKIKQALYTPLQPSPSAHAYNPQFMVDIITNPRRGGKIENAWARQLNESASNRYSFVCNAVIAVTRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLSQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKSRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHKVSSIFGTGKRSGLNTPVHPGSTPKSMAGSGDLSHILGTSDLSVLGNADESMLDVSQQNSHLNQENATSLSDFAQHVLRQICSQEWVLERCLQNAEELCQQGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELDQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCSSPELSNWLDMVARAAIDVFRVNEFSLSSTADVKQEKVKPSTWLVAPLVSKLPSAVQGRILKVSGQVLESTSMFSKHKDGNGGNSSNNNSSHSHGANSNSSVSSNGSTFGSKQSAQLNHQPFLGLVLTCLKGQDEQKEGLLQSLYAQLSQFLQNRDQSLETVGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDRNGPSIKYVRQLLPLAKQTCEVITCDSAGSSTDAKGNKISIDSIEKKNGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEPNNSKQALLQMIRAKVPINAGHPGTFMSQQQQPQRNPQQQQFMRGPLRAGIPGNPGIAGSQVGMGPMNPAMAGGNAGLGAGAGGAVMGGQAMNAGGMMGAQQGGQVQQASGAGIMNQSAAAMMGSAGGSIMGQSGGSMIQTNMLNPQQNPAMVGQGMGAGGGIGAGSGMAGNAGMGGGAGGMGGTAGAMNSGGGGMVAAGGMVNAGGMGNSGINAAAMVGGQGGMGGNSGMANASGMGNPTMNNAGMGMQNMQQAGGNMQAGMFQGQNVPYQNVNQNYPNYGNQGMGQQGGQGGGMMGNFNQMAQQQRNTQAEFLAQRAAMAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGANIPQNQQQFQQQQRLRLMMQQQQQQQQQQQQQQQGGMGQGGNAQAMMQNQGQGMSTQQTPNLVAQLQRQNSMMGQQYPHQPPQY
Length2360
PositionKinase
OrganismAnopheles atroparvus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.06
Grand average of hydropathy-0.408
Instability index45.98
Isoelectric point6.57
Molecular weight255743.30
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07901
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     277.21|      25|      25|    2043|    2067|       1
---------------------------------------------------------------------------
  242-  270 (29.49/ 8.00)	P.........lsspaGS...M.........HSPA..G...GS.AGVGSMHPQQQQQ
 1954- 1985 (27.08/ 6.74)	Q..............QQF..MrgplragipGNPGiaG...S...QVGM.GP.MNPA
 2037- 2066 (39.56/13.25)	M.........mgsagGSI..M.........GQSG..G...SM.IQTNMLNPQQNPA
 2067- 2089 (30.51/ 8.53)	M.............vGQG..M.........GAGG..G...IG.AGSGMAG...NAG
 2133- 2160 (30.71/ 8.64)	M.........vggqgG....M.........GGNS..G...MA.NASGMGNPTMNNA
 2161- 2186 (31.32/ 8.95)	G..............MGMqnM.........QQAG..G...NM..QAGMFQGQNVPY
 2187- 2225 (29.50/ 8.01)	QnvnqnypnygnqgmGQQ..G.........GQGG..G...MM.GNFNQMAQQQRNT
 2287- 2308 (28.04/ 7.24)	Q..............QQR..L.........RL........MM.QQQQQQQQQQQQQ
 2309- 2337 (31.00/ 8.79)	Q..............QGG..M.........GQGG..NaqaMMqNQGQGMSTQQTPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     227.59|      58|     188|     371|     428|       2
---------------------------------------------------------------------------
  371-  428 (100.43/60.08)	DSHNINLNS..TDLEPGCKSSMETQDG....KDKTLEKPSKDSP....SGG.AAPHGVDGKPARANPFE
  558-  616 (79.50/45.50)	DSNN.SLDSlySKIFPPFQ.VQPIKPT....ESSTTGGNGKASQ....GGGqSGTTGADGKDAATKQLE
  665-  714 (47.66/23.31)	DSYSNNLNN..SDDKDSMLSGSGLNGGqpvfQHILMNFLDNDAPvleeSGG.A................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.88|      16|      16|     734|     749|       3
---------------------------------------------------------------------------
  732-  747 (31.40/19.66)	RHDVFSHDAYMCCLIS
  748-  763 (27.49/16.19)	RGDLLTGAGGMLSLDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.80|      12|      17|    1990|    2001|       4
---------------------------------------------------------------------------
 1990- 2001 (23.34/ 8.28)	NAG.LGAGAGGAV
 2100- 2112 (20.46/ 6.27)	TAGaMNSGGGGMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.89|      17|     188|     867|     888|       7
---------------------------------------------------------------------------
  869-  888 (30.45/33.70)	LCQddpISQH.....DCN..QRYILLY
 1062- 1085 (24.44/ 9.17)	LCR...IVKHvsnpsDCSsaERCILAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.02|      15|      15|    1385|    1399|       8
---------------------------------------------------------------------------
 1363- 1382 (19.07/ 7.45)	SIFGTGKRSGLntpvhPGST
 1385- 1399 (25.99/13.06)	SMAGSGDLSHI.....LGTS
 1402- 1415 (21.95/ 9.79)	SVLGNADES.M.....LDVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.52|      13|      15|    1439|    1451|       9
---------------------------------------------------------------------------
 1439- 1451 (24.91/14.94)	QICSQEWVLERCL
 1456- 1468 (21.61/11.87)	ELCQQGMLIDNLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.95|      18|      19|    1150|    1167|      10
---------------------------------------------------------------------------
 1150- 1167 (32.18/19.00)	AWARQLNESASNRYSFVC
 1172- 1189 (31.77/18.67)	AVTRDIDNDCLNDIAAMC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.68|      10|     294|    1424|    1433|      12
---------------------------------------------------------------------------
 1424- 1433 (17.97/11.93)	ENATSLSDFA
 1721- 1730 (19.71/13.94)	KNATSTTDWA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.25|      35|      38|    1263|    1297|      14
---------------------------------------------------------------------------
 1263- 1297 (60.80/40.68)	PSLVQACKSRGETTPEIEAGARLSC..HLLLRLFKTI
 1302- 1338 (57.44/37.98)	PGLYSVSTSPNPITVGNAHNIKLSCdrHLLAAAHKNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.48|      44|     298|    1556|    1648|      15
---------------------------------------------------------------------------
  189-  237 (68.03/14.58)	LVPKLHEHYHQGPLqeKSASGVSGSSGGLSGGGGGGlgmGSSASSANPS
 1575- 1618 (74.46/51.18)	LVSKLPSAVQGRIL..KVSGQVLESTSMFSKHKDGN...GGNSSNNNSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.30|      14|      18|    1833|    1846|      24
---------------------------------------------------------------------------
 1833- 1846 (23.31/12.54)	ISI.DSIE.KKNGLRL
 1852- 1867 (15.99/ 6.38)	VSVwDLLEgHKNPAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.46|      10|     108|    2004|    2014|      25
---------------------------------------------------------------------------
 2004- 2014 (16.76/11.14)	GQAMNAGGmMG
 2115- 2124 (20.69/ 8.93)	GGMVNAGG.MG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.20|      15|     743|     779|     793|      26
---------------------------------------------------------------------------
  779-  793 (29.30/17.44)	KPTNTSSPHNATGMD
 1523- 1537 (29.90/17.97)	KQTNCSSPELSNWLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.74|      23|      27|    1736|    1758|      29
---------------------------------------------------------------------------
 1736- 1758 (36.72/26.31)	LISQGVIDLSNNSELFTTTLDML
 1766- 1788 (37.02/26.60)	LVSDSQTERDENKKLYTNLMKKL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07901 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGHPGTFMSQQQQPQRNPQQQQFMRGPLRAGIPGNPGIAGSQVGMGPMNPAMAGGN
2) DLDKLLQHIKEDQQNSMDAPDSPKDPEQAAPSVAGL
3) DLEPGCKSSMETQDGKDKTLEKPSKDSPSGGAAPHGVDG
4) HEHYHQGPLQEKSASGVSGSSGGLSGGGGGGLGMGSSASSANPSTIPPPLSSPAGSMHSPAGGSAGVGSMHPQQQQQLPPISPQEEQRI
5) MFSKHKDGNGGNSSNNNSSHSHGANSNSSVSSNGSTFG
6) MNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKH
7) NVNQNYPNYGNQGMGQQGGQGGGMMGNFNQMAQQQRNTQAEFLAQRAAMAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGANIPQNQQQFQQQQRLRLMMQQQQQQQQQQQQQQQGGMGQGGNAQAMMQNQGQGMSTQQTPNLVAQLQRQNSMMGQQYPHQPPQY
8) PIKPTESSTTGGNGKASQGGGQSGTTGADGKDAATKQ
1935
816
381
194
1600
1
2188
578
1990
851
419
282
1637
35
2360
614










Molecular Recognition Features






MoRF SequenceStartStop




1) MNMRPLKRPRLGPPDVY
1
17