<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07899

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSAELRIVKLFEEVLEDKNIVPSYDEEEQRKRTEEGYKKIGTLFGAMTPEVKEASIRSYLGYVATVNHQNRVHNYLQVMNRMVAMNIIPAKLLCDQLMCSDKLTYKNPCFWIEAFQIVRKVIGGVDYKGVREIMKCCKEKAHSFPVNVSVNILPQLLELVALIEHIFNRNASLLPAYFIINEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSIIGHSSMLPIVEHSSYVDNLIIPWKLDPDTLKLALRGNLPYDDELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMEYSEKEGNPVGPNAAGAGMNDHDDVATHTQWIWLHLSSQLIYFVLFQFATFQNIVNTLHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPILKLYDILYPEKEPLPVPDYNNPYCTHQMAPTCIWIHLMKRAQTENYNINRPIPIALRLHFEYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQAMVSGGVQPLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSAIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSHAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYVSEPKPPGNIVSAESEELNRALVLTLARSMHITGTGNDPQSSAWCKDLLQNIMLNTPHAWPQHTLFCFPPVLNEFFMQHNIPKENKQLLKKTVDEEFRNWASMTNENDIIAHFGMAVNPPLFLCLVFKMIIETDAISPVAYKILERIGARALSTHLRKLCDYLLFEVANSGGSAPHVNKCVDTINDMIWKYNIVTIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTSEFRNRVQEFISINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPSLPVYFGNVCLRFLPVLDIIVHRYLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGTVVGSLKDVRPENWALTEPYQAYMMKKENDNVNWVPELSYYINLVRRMQDTMDGKNVFSGTDWRFNEFPNPPAHALYVTCVELLGLPVGPNVVANSIIDVLVKGYTVVPSRVFHNWTNTIGLIMAALPEAYWSVIYERMQEALNSPAMKDWAYRQSPFEMFNFKVVKETMLDRSYVTVLAIVHSIFHHFGIGQLATITDSLKEKLKPLVHTEYQLIYLCHVVGPFLNRLSIERTRAVSDITVMLYELLEQVDKGQPTQPLRYMDPICDLLYHIKYMFVGDTMKPELEAIIRRLRPALQMRLRFITRLNVDEIGVDQNVANAAHGQSTVAMPAQGSAVVGVGPGTINATGVGPQVTGGSVGPAVPQQTVGGGMNQNIALQQQLQQQQQQHQQQQQQQLQQQMGQGMQVHH
Length1449
PositionTail
OrganismAnopheles atroparvus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.09
Grand average of hydropathy-0.134
Instability index44.66
Isoelectric point7.65
Molecular weight165956.36
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07899
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     865.16|     278|     327|     665|     988|       1
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  409-  616 (198.11/94.86)	...................................................................................................................................LYDILY.....PEKE.P......LPvPDYNNP.YCTHQMAPTCiwIHLMKRAQT...ENYNiNRpipIALRLHFEYLQHLAMpSNNPTLFmgseyrfalLCNAYS..TQTDYFSrP..MQALIDTILGnsknPQAM................VSGGvqplpTAPLSMRVLDSLT.IHSKMSL..IHSIVMHMIKQAqnksaiPNGNNMAPALVETYSRLLVYTEIESlGIKGFLGQLLPQVFKSHAW
  631-  937 (443.23/277.50)	HHIHSHYRVQLLTHLHSLASVPHTNqmqLHS.....CVE...................STALRLIIG.LGSV.EVQAQLSRYVSEPKPPGNIVSAESEELNRALVLTlarsmhITGTGNDPQSSAWC.KDLLQNIML...NTPHAW.PQHTLFcFP.PVLNEF.FMQHNIPKEN..KQLLKKTVD...EEFR.NW...ASMTNENDIIAHFGM.AVNPPLF.........LCLVFKMIIETDAIS.P..VAYKILERIG....ARALsthlrklcdyllfevaNSGG.....SAPHVNKCVDTINdMIWKYNIvtIDRLVLCLILRT......LDGNEAQVSFYIIQLLLLKTSEFRN.RVQEFISINSPEHWKQNNW
  938- 1161 (223.82/137.87)	HERHLAFHQKFPEKFAPDESVSHPS...LPVyfgnvCLRflpvldiivhrylevptqlSKTLDVILDhLGSLyKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGT......VVGSLKDVRPENWAlTEPYQAYMMkkeNDNVNWvPELSYY......INLVrRMQDTM..DG..KNVFSGT.DwrfNEFP.NP...PAHALYVTCVELLGL.PVGPNVV.........ANSIIDVLVKGYTVV.PsrVFHNWTNTIG.......................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.71|      45|     145|      87|     136|       2
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   87-  136 (67.19/56.38)	IIPAKLLCD..QLMCSDKLTYKNPCFWIEAfQIVRKVIGGvDYKgvREiMKC
  235-  281 (78.52/45.71)	IIPWKLDPDtlKLALRGNLPYDDELLQPQA.RLLRFVLQQ.PYS..RD.MVC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.45|      16|      16|    1367|    1382|       3
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 1367- 1382 (29.25/19.63)	TVAMPAQGSAVVG..VGP
 1384- 1401 (25.20/15.84)	TINATGVGPQVTGgsVGP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.52|      44|      47|     297|     343|       4
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  297-  343 (75.17/68.28)	LEEQLVWLVLNAMEYSEKEGNPVGPNAAGAGMNDHDDvatHTQWIWL
  345-  388 (75.36/59.46)	LSSQLIYFVLFQFATFQNIVNTLHEKLAVRNLRRGRD...HLMWVFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.97|      27|      47|     147|     175|       7
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  147-  175 (35.36/26.20)	NVSVNILPQLLElVALIEHIFNrNASLLP
  197-  223 (45.61/24.87)	NLTANFIEEFVS.VAQMLSIIG.HSSMLP
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.63|      17|      17|    1413|    1429|       8
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 1413- 1429 (30.97/17.38)	NQNIALQQQLQQQQQQH
 1432- 1448 (32.66/18.72)	QQQQQLQQQMGQGMQVH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07899 with Med23 domain of Kingdom Metazoa
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