<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07898

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTPSINSVFSSAHQTALANNMASKRESILQMLQSLKRPSLYCKDYETLQGEDIPSTSQLLYDYSSLDAWMNHPVKRMRLAPEENRQVKQTRNLDLYANENARTMAGFNSGNNATTNGMLLKGGGGSTGNDASDALMSEHGGGGGAFDNGASSNGLLGHGQIKLEHGCDGGQQGQDGRQGDGGANGTPDRNGVAGGADGALLGEHEIKKEKEDKGGGYSLFTDQDLQPSIDDLNQIFDDGGPFNDDADMHNTPPGSNKSSGGGSGGFGSEDNKRYPSSNHHSVNSGILSPKELSQMFPTPPSLDPHPTASSNVHLLEYVDANDVISLALEHGRLQALIESKLDLDHPAGSSSALVRGGTMRGVMNAHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTLRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDFVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDHQQQLQQRKNGNGASSSGNASSSSSSSSPSGLNELLRLYAQTCQQQLAPYLSKVPTDKSLLDPPESHHTLSSSSSSSSSAGAGSSSMGGSGMGQSGGMGSGRDGVGGPGQSPMPPPPPSTPDPSQPGDKAPNTPKFDHDAENRDLNTSAANPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPESIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFMKRKDDKNRVPYRLYTPPYVLAKSCEKSENTEAFGKTTMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCALMHPISVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGEDDDDAINMMDVFKCWDDLPMQQINMPHSRPGSPLHFEGNQQSPGESGLKGAGARDGYGLLDSEEVGLVLQQPLAIGYLVSTAPTGRMPAWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length1257
PositionMiddle
OrganismAnopheles atroparvus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.06
Grand average of hydropathy-0.500
Instability index50.72
Isoelectric point5.75
Molecular weight137191.31
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07898
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     210.46|      45|      48|     155|     199|       1
---------------------------------------------------------------------------
  131-  147 (23.31/ 7.21)	.......ASDALMS......EHG.GGG....................................GAFD
  148-  188 (73.32/42.73)	.N...GASSNGLLGHGQIKLEHGCDGG..................Q.QGQDGRQGDGGA...NGTPD
  189-  254 (55.09/29.78)	RNGVAGGADGALLGEHEIKKEKEDKGGgyslftdqdlqpsiddlnQ.IFDDGGPFNDDAdmhNTPPG
  621-  660 (58.74/32.37)	SSSSAGAGSSSMGGSG.....MGQSGG..................MgSGRDGVGGPGQS...PMPP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     722.45|     239|     433|     256|     529|       2
---------------------------------------------------------------------------
  256-  529 (374.46/312.39)	NKSSGGGSGGFGSEDNKRYPSsnhHSVnSGILSPkelsqmFpTPPSLDPHPTASSNVHLLE.YVDANDVISLALEHG.RLQAL.IESKLDLdhpaGSSSALVR.GGTMR....GVMNAHKWPF........LRAGGPKSNQDivRIMKSMQpllqdafHKRCTTLRLWDAPYTIQGPLTWRQFHRLAGRGT..GQCEPqPIPSLIVGYEKDWLslapYALHYWDK.LLLEPYSYPRDvayvaiVPD.........NDFVVAKVRTYFKELST......TYEMCKLGR..HTPIKGWDGIL.RVGSQRV...LKE
  691-  969 (347.99/217.49)	NTSAANPADGMRIDDDGKDPP...HIV.LYIVEP......F.TCGNDSPDVERLACLSLLRcYSNILNAVPESIRSNiSVQIIsLESILEL....GRNRNRLRlSDHMRclalSVFSQSRKYLahmntvksLTGFGTAANAE..QFMKRKD.......DKNRVPYRLYTPPYVLAKSCEKSENTEAFGKTTmkQQCSI.MYCSYCLSEDQSWL....LAVATDDRgEFLETVTINID......IPNrgrrkrasaRRYGLQKLMDFILGLISqtvqpwRLVVGRIGRigHGELKGWSWLLsKPNLQRAskhLKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.82|      15|      15|      97|     111|       3
---------------------------------------------------------------------------
   97-  111 (26.87/17.43)	ANENARTM..AGFNSGN
  113-  129 (21.94/12.63)	ATTNGMLLkgGGGSTGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.59|      31|      74|     994|    1024|       4
---------------------------------------------------------------------------
  994- 1024 (55.90/30.37)	EPDSDLRVMSDQFTPDERFSQRSMQSPLSTP
 1068- 1098 (60.69/33.56)	EDDDDAINMMDVFKCWDDLPMQQINMPHSRP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07898 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) INMPHSRPGSPLHFEGNQQSPGESGLKGAGA
2) NENARTMAGFNSGNNATTNGMLLKGGGGSTGNDASDALMSEHGGGGGAFDNGASSNGLLGHGQIKLEHGCDGGQQGQDGRQGDGGANGTPDRNGVAGGADGALLGEHEIKKEKEDKGGGYSLFTDQDLQPSIDDLNQIFDDGGPFNDDADMHNTPPGSNKSSGGGSGGFGSEDNKRYPSSNHHSVNSGILSPKELSQMFPTPPSLDPHPTASSN
3) QLAPYLSKVPTDKSLLDPPESHHTLSSSSSSSSSAGAGSSSMGGSGMGQSGGMGSGRDGVGGPGQSPMPPPPPSTPDPSQPGDKAPNTPKFDHDAENRDLNTSAANPADGMRIDDDGKD
4) WFTNMGVDHQQQLQQRKNGNGASSSGNASSSSSSSSPSGLNELLRLY
1091
98
591
538
1121
311
709
584










Molecular Recognition Features






MoRF SequenceStartStop




NANANA