<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07890

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPQPLEQGGAVTSFIPTGQEMVQRQNLIPLNRLIDFIIQRTYHELTVLAELLPRKTDMDRKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSSKIMGFLDKQSMLFIDTADMLSRVARETLVHARLPNFHIPAAVEILTTGSYSRLPSVIRERIVPPDPITPAEKRQTLQRLNQVIQHRLVTGNLLPQLRKFRIENGRVTFKVDHEFEVSLTVMGDAPTVPWRLLDIDFLVEDKETGDGKALVHPLQVNYIHQLIQGRIVDCTDALAEVYTCLHYFCQSLQLEVLYTQTLRLIRDRLDDHIHVDEYVVGSKLTVSYWRELTNKDPKSELGYRLTIQTDPNDAAKQLAILHVPSIGNKEADIADRAVRSDLLSMERLLVHTVYVRSLARLNDVKAELQLFLKDVDYHIQGTPAMLTVPVLNPCLRAEHIYITVDTHTGMLRCHVPKHLDCPIMPEMQHALNNDWSKLQHLISELRYWITQRRCEKTLQHLPAATQDRLPLVLPPNHPITRMGPHKVFIQLYRHANVILIVELKEKKTSPNEMTYTFYLVLVKPSSVEEGQSPDGPANATGAQSSTAAGGAGGQSGNDTAATMPKMYLRVLSMIEFDTFVATHGPGTVIDDPITGCSKRKMSALESTSVPFLGPPIKQQKTIYPAYFIPELAHVVAMCDDKLPFVALAKEFSHRRIPHGGLQVEANATSLVLKLLTLPQPKPPQIAPSPQQQQGGQQAGQHQQQGNAGADGKAGTNEPKTVHVPPIDKQVWSALLKRLLSVSVRAQVNKSNQTRLWTMELVFYGSPLPSLHHKEQGMRRAVYLQYEMLPVESVGKVVDQLLNDWSKIVYLYTLVHEFREQLQNEKYNLQNMVAIRSYNYTNLLLAYGPNKEVSVSICWDTEAKEFRLVFTGGNSSINAHSMMRDQLQAHLNHNYSLAQIVHILHETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPNLLRISFQGVYCLEVRFRGGGLCTIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVFRRRSQSEDDNPPSPVTMEDPSGHGGGGGGAVGGGGGQGPGSVGSNTFLGGAAGMRGPQSPRDPGLRFAAPLTPPSGSNPHTPASPHPIGGGGGAGGPVGGGGGQGQGGQGGQQGHMNNFNMTSPPASHMPHPSPSGGLMPSSPLNAQPSPMAAHSPGPSNLPYMQNHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTHYNTSRVLPARSWAGAVPTLLTYEALDTLCRATSHPQKEVPGPELSPLERFLGSVFMRRQLQRIIHQEESLMAITSNEPGVVVFKADCLQYQVFLNPNHMQSLHLKVNQLPMGPMMDGKPPYQWAAEDLQILEQFFDHRVAAPPYRPAVMTSFTRMLNLPAKVLMDFIQIMRLDLMPELGQGNKWNVQFVLRMPPSATPIVPVGTTTILSHRQKILFFIQITRIPYLPNMEWKDAVTMLLPMVYDMNMNHTTLAERREPMPPQLTSAVSAHLRRFSDCSVLLPDECSLFPAVRDLLLTLTLPNEPPTPGQIQMQLGGVMQPGPGGPGGPMGGQIAGPAPQVGPQVGSSPGPMMHSPMQQMGVGGQQPGSYGGMVGGAGGGPQAGGPGGGGPGGPN
Length1636
PositionTail
OrganismAnopheles atroparvus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.06
Grand average of hydropathy-0.268
Instability index51.54
Isoelectric point8.56
Molecular weight179689.44
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07890
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     367.30|      62|      62|    1061|    1122|       1
---------------------------------------------------------------------------
  709-  742 (44.07/11.88)	PQ...PKPPQI.APSPQQQQ..GGQQ......AGQHQqQG.NA.......G.ADG..........................
 1061- 1091 (44.82/12.21)	......................................GG.GGA....VGG.GGGQ...GPGSVG..SNTFLGGAAG.MRG
 1092- 1153 (94.46/33.90)	PQ..SPRDPGLRFAAPLTPP..SGSNPHTP..ASPHPiGG.GGGaggpVGG.GGGQ...GQG..G..Q....GGQQGhMNN
 1154- 1212 (79.56/27.39)	FNmtSP..PASHMPHP.SPS..GGLMPSSPlnAQPSP...........M.A.AHSP...GPSNLPymQNHTDGSPFA.ALS
 1557- 1583 (33.48/ 7.26)	.........................................GGV....MQP.GPG....GPGG.P..MGGQIAGPAP.QVG
 1584- 1635 (70.91/23.61)	PQ..VGSSPGPMMHSPMQQMgvGGQQPGS...........yGGM....VGGaGGGPqagGPGGGG..P....GGP......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     530.22|     218|     479|     797|    1053|       2
---------------------------------------------------------------------------
  237-  392 (132.78/67.36)	KETGDGKALVhpLQ.....VNYIhqliqGRIVD..CTD..ALAEVYTCLHYFCQSLQLEVLYTQTLRLIRDRLDDHIHVdEYVVGSKLTVS.YWreltNKDPKselGYRLtIQTDPNdaakqlailhvpSIGNKEADIADRaVRSDL...LSMERL..LVHTVY..VRSLARL...................................................................................................................................
  804- 1053 (323.68/282.68)	KEQGMRRAVY..LQyemlpVESV.....GKVVDqlLNDwsKIVYLYTLVHEFREQLQNEKYNLQNMVAIRSYNYTNLLL.AYGPNKEVSVSiCW....DTEAK...EFRL.VFTGGN............SSINAHSMMRDQ.LQAHLnhnYSLAQIvhILHETYqpLSSIAKLPIIP.HLAILQSPKIPVLSFCIIPQSPNLLRISFQG........VYclEVRFRGGGLCtirdgaySRfdRshvvEEFTP..TQGLKGFLSKYVD.......ETAVF...RR..RSQSEDDNPPSP..VTME
 1440- 1555 (73.76/32.19)	.............................................................................................................................................................................PIVPvGTTTILSHRQKILFFIQITRIPYLPNMEWKDavtmllpmVY..DMNMNHTTLA.......ER..R....EPMPPqlTSAVSAHLRRFSDcsvllpdECSLFpavRDllLTLTLPNEPPTPgqIQMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     421.13|     121|     479|      94|     228|       3
---------------------------------------------------------------------------
   94-  216 (197.41/114.12)	KSSKIMGFLDKQSMlfIDTADMLSRVARETLVHARLPNF...HIPAAV.EILTTGSYSRLPSVIRE.RIVP.PDPITPAEKRQT.........LQRLNQVIQHRLVTGNLLPQLRKF.RIENGRVTFKVDHEFEVSLTV
  466-  532 (80.48/38.51)	........................................................WSKLQHLISElRYW.....ITQRRCEKT.........LQHLPAATQDRLPL..VLPPNHPItRMGPHKVFIQLYRHANVILIV
  574-  690 (143.24/83.34)	QSSTAAGGAGGQSG..NDTAATMPKMYLRVLSMIEFDTFvatHGPGTViDDPITGCSKRKMSALES.TSVPfLGP..PIKQQKTiypayfipeLAHVVAMCDDKLPFVALAKEFSHR.RIPHG................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.70|      20|      41|    1235|    1275|       4
---------------------------------------------------------------------------
 1235- 1258 (30.26/42.10)	PEHKVQthynTSRVLPARSWAGAV
 1277- 1296 (34.44/ 7.88)	PQKEVP....GPELSPLERFLGSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.09|      21|      48|    1338|    1358|       8
---------------------------------------------------------------------------
 1338- 1358 (39.00/26.31)	PNHMQSLHLKVNQLPMGPMMD
 1388- 1407 (31.77/19.75)	PAVMTSFTRMLN.LPAKVLMD
 1408- 1423 (18.32/ 7.53)	FIQIMRLDL.MPELGQG....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.33|      25|      30|     396|     422|       9
---------------------------------------------------------------------------
  396-  422 (35.08/26.27)	KAElQLFLkDVDYHIQ....GTPAMLTVPVL
  427-  455 (42.26/22.90)	RAE.HIYI.TVDTHTGmlrcHVPKHLDCPIM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07890 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FRRRSQSEDDNPPSPVTMEDPSGHGGGGGGAVGGGGGQGPGSVGSNTFLGGAAGMRGPQSPRDPGLRFAAPLTPPSGSNPHTPASPHPIGGGGGAGGPVGGGGGQGQGGQGGQQGHMNNFNMTSPPASHMPHPSPSGGLMPSSPLNAQPSPMAAHSPGPSNLPYMQNHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTHYNTS
2) KPPQIAPSPQQQQGGQQAGQHQQQGNAGADGKAGTNEPKTVH
3) LTLTLPNEPPTPGQIQMQLGGVMQPGPGGPGGPMGGQIAGPAPQVGPQVGSSPGPMMHSPMQQMGVGGQQPGSYGGMVGGAGGGPQAGGPGGGGPGGPN
1035
712
1538
1246
753
1636










Molecular Recognition Features






MoRF SequenceStartStop




NANANA