<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07883

Description Uncharacterized protein
SequenceMVHLDPLRLCRKKRKIPQGGAILDQVISQSASASNQCLLYKMANYKRGGDLIDAFQIGGQKAVEQLIREQFGVFMYNKGRGQIINRAEYLRWKYMDNHEVGCRALDPECLNFPTFTVSQVIIPIEASLSPHDPLSKWVDHKACWQMQYRGLLGESLLHVLIICDTKVHTKLARILLRVFPEQAIDVMEGEEYLGASALHLAIAYSNNELVGDLIDAGADVSQRATGRFFLPRDQQGLRPAKTTDYEGLAYLGEYPLAWAACCANESVYNLLLECGADPNAQDSFGNMILHMVVVCDKLDMFGYALRHPKLPCKNGIVNAAGLTPLTLACRLGRDEVFREMLELSAREFWRYSNITCSGYPLNALDTLMPDGSTNWNSALFIILNGTKEEHLNMLDGGIVERLLDEKWKTFARNQFLKRLLILAIHLFCLSCSVYLRPVRVFDDDDADGGDDDAGGDSGEVSAGGNSGEAGDDGGAGDPIDLSTWVRYGFEVATVMGVLSYVVLQQGDEIKNQGFFSFLKSLGQAPAKAIFLISNILILACIPLRIMGDTETEEAILLFAVPGSWFLLMFFAGAIGLTGPFVTMIFSMITGDMFTFGIIYMIVLFGFSQAFFFLYKGHPNAEDSPFGSYFGTWMALFQTTLGDYDYADLNLTTYPNLAKTVFVIFMIFVPILLLNMLIAMMGNTYAYVIEQAEKEGMKQWAKIVVNLERAVTQDDAKRYLEEYSIGLGPSDDPRYETRGVMVIKSKSKTRARQRKGAVSNWKSVLRVTLNELKKRDMTGEELRRIMWGRSSITSPAKIAKKKRGGEDDLSDPFAITAAIDVMSFTQDIVMVSTETTVAPPSIPGTVGPTAVRPGPTIAPAVPPTATVTFPPPAQAPRSAPPAPSAPRRHSTASAPAAMGLSAETRAGDYKDPLRELVMISESTSVDENYAQNVKTLAIDASTLDHVHEIDISSLQSGASPYYRHDQHQQQQQQQLEQAQQQQQQQQQQQQQQQPQQPQQLQGGLTLFQNPKDIVDPVREREFLKTLEALEDTDSEAGEKPVLGKISLIRRAKSAVSRSTSRKRKTDQHPLFMIAWEDKGTPVAMLGEPSMLPPYADDTVQQLPPAPATGLGEAGGQGEGGGVGENDTVTVEELHRRMEQFHQRSRASSVRERDVNSSESSGKHGKARKGTHGGGGGGHGHGMARGKHNKISPDNSNESTGGGSAGKPDKRMKSAPILGGGGGGGGGGGTVAARHHAGAAGRGDQAGTGSPPDPLEPWSTKNIMNINRLLDQDTTEE
Length1275
PositionKinase
OrganismAnopheles atroparvus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.08
Grand average of hydropathy-0.291
Instability index46.00
Isoelectric point5.82
Molecular weight139496.91
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW

GO - Biological Function
ion channel activity	GO:0005216	IEA:InterPro

GO - Biological Process
response to stimulus	GO:0050896	IEA:UniProtKB-KW









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07883
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.81|      16|      16|     967|     982|       1
---------------------------------------------------------------------------
  962-  977 (30.15/19.12)	RHDQHQQQQQQQLEQA
  978-  993 (32.66/21.27)	QQQQQQQQQQQQQQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.51|      40|      44|    1144|    1186|       2
---------------------------------------------------------------------------
 1144- 1186 (69.87/36.70)	RASSvreRDVNSSESSGKHGKARKGTH......GGGGGGHGHGMARGKH
 1188- 1233 (66.64/29.42)	KISP...DNSNESTGGGSAGKPDKRMKsapilgGGGGGGGGGGTVAARH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.62|      16|      16|     839|     854|       3
---------------------------------------------------------------------------
  839-  852 (21.79/ 7.95)	.....PSIPGTVGPTAVRP
  853-  871 (24.43/ 9.76)	GPtiaPAVPPTATVTFPPP
  874-  887 (27.39/11.78)	AP...RSAPPA..PSAPRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.96|      12|      15|     304|     315|       4
---------------------------------------------------------------------------
  304-  315 (23.43/12.79)	ALRHPKLPCKNG
  321-  332 (21.53/11.21)	GLTPLTLACRLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.32|      13|      15|     446|     458|       5
---------------------------------------------------------------------------
  446-  458 (25.22/10.85)	ADGGDDDAGGDSG
  462-  474 (25.10/10.77)	AGGNSGEAGDDGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.61|      16|      16|     270|     285|       6
---------------------------------------------------------------------------
  270-  285 (28.32/17.34)	LLLECGADPNAQDSFG
  287-  302 (29.29/18.17)	MILHMVVVCDKLDMFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.49|      19|     128|     521|     549|       7
---------------------------------------------------------------------------
  489-  508 (26.94/23.75)	FEVATVMgVLSYVVLQ.QGDE
  530-  549 (28.55/16.95)	FLISNIL.ILACIPLRiMGDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.70|      16|     128|    1104|    1138|       8
---------------------------------------------------------------------------
 1075- 1101 (17.18/16.32)	EDKGTPVamlGEpsmlppyaDD..TVQQL
 1115- 1132 (24.52/18.36)	QGEGGGV...GE........NDtvTVEEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.95|      23|     128|     632|     661|      10
---------------------------------------------------------------------------
  618-  653 (30.18/38.80)	PNAEDSPFgsyfgtWMALFQTTLgdydyadLNL......TTY
  654-  684 (30.77/19.62)	PNLAKTVF....viFMIFVPILL.......LNMliammgNTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.87|      33|     161|      31|      72|      11
---------------------------------------------------------------------------
   31-   65 (55.71/30.11)	ASASNQCLLYkmANYKRGGDLIDAFQIGGQKAVEQ
  195-  227 (54.16/23.59)	ASALHLAIAY..SNNELVGDLIDAGADVSQRATGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.37|      15|      17|     907|     922|      12
---------------------------------------------------------------------------
  907-  922 (20.87/20.96)	DYKDPLRELVmISEST
  927-  941 (24.50/17.78)	NYAQNVKTLA.IDAST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.07|      14|      56|     180|     194|      13
---------------------------------------------------------------------------
  180-  194 (22.55/16.61)	PEQAIDvMEGEEYLG
  239-  252 (26.51/15.00)	PAKTTD.YEGLAYLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.63|      15|      43|     555|     569|      14
---------------------------------------------------------------------------
  555-  569 (27.32/20.75)	ILLFAVPGSWFLLMF
  583-  597 (25.32/18.51)	MIFSMITGDMFTFGI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07883 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DHVHEIDISSLQSGASPYYRHDQHQQQQQQQLEQAQQQQQQQQQQQQQQQPQQPQQLQGGLTLFQNPK
2) KSAVSRSTSRKRKTDQHPLFMIAWEDKGTPVAMLGEPSMLPPYADDTVQQLPPAPATGLGEAGGQGEGGGVGENDTVTVEELHRRMEQFHQRSRASSVRERDVNSSESSGKHGKARKGTHGGGGGGHGHGMARGKHNKISPDNSNESTGGGSAGKPDKRMKSAPILGGGGGGGGGGGTVAARHHAGAAGRGDQAGTGSPPDPLEPWSTKNIMNINRLLDQDTTEE
3) STETTVAPPSIPGTVGPTAVRPGPTIAPAVPPTATVTFPPPAQAPRSAPPAPSAPRRHSTASAPAAMGLSAETRAGDYKDPLRELVMISESTSV
4) VREREFLKTLEALEDTDSEAGEKPVLGKISLIRR
943
1051
831
1016
1010
1275
924
1049










Molecular Recognition Features






MoRF SequenceStartStop




1) LEPWSTKNIMNINRLLDQDTTE
2) PDKRMKSAPILGG
3) TVAARHHAGAAGRGD
1253
1206
1228
1274
1218
1242