<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07872

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSTGSAVTGGSLPALLMANGGGGPPGLGPGGGKGVGGHGGKPDVKPPSLGSTSGVGGGGAGGGSVPGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFPEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTSRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHALYALSAQRYPDVHSLLLQAPLGVVQKRRGGHPMRLTYFVAPYDLLDLDARTMNVLSAELIAQERIGCSVAVVLEAASANKLQVQPLLVPTSSTAAVPVYTPIEKHNSTSLPATFVLRLSKQMPINAATMRTIRGIVAGGGGGAPGVELAPSTGERLPSSLLGLIAHHASGGSVTDLSRGLPVTLPDQQHCYYLTDNPALQGVMVASIPFTEPQHVPRILTLLRQAAVFNQLLASCIRTHSSNRAGAGVIPALEENGTMAGFLVFEVTALSCQYITVSLMHPYEESLATVEFDLQNIASISVRIYGTGGGGGDEGEEPGCDQQTVDRLSAVLQRCMSIPVTLRALLKHWDEQHEQKYKLLGESALDPSASNGGPGGGTGSGTGGLPNGDGGPASGGGSSALGDDVGGANGFSLASLGAGTSTTTPLDGGGGGLAMNGTNCQQNQQQRALFNGSNGGGGNGTTAGNNLIVGGGNLGLDFCDMLAGRNGMSAAMGGVMRGMGGTVGQREPPEPLVGGVAKKRRMEDFCKSPKSESNLSGAGACGNDGGGIGGGTEGINHQDTSFCTAPGTGGSNVTSTGGDNGRTVPSSSSGAGTMLVGSEQRMQSVGGTEGDAGGLDSKGNSLGGTTTTTNFTTAPAMTTASATTMTTTTIKTDPPGVHGYTTTKADTTTSTTISSSSSSSITTKTAAMTTEASVRSAGTLLLESLDFSALEDSALDPMTTKGRPAVKRRRNSSSSSSSSSSSSSSSSSSSSSSGSDDIEETVDLVEAEMSSFFSETAAGNDAVSGSNTQLSALAGGADATSTSGGSSIVAMPKESPAKPSPAPGTNAALCAITPVAARVGPTPPGSGNAASSGFDKRPPGMTTTMTTTTTSADGGLEIIPLAATAPPTATAIGVGGSLTSSVTITPIATVATASSSATSSSTSSSSASKKSSSSSSSGAGSHRKAGGDSERSSSTSGKTEKKKKRKADDTAMGPPNKLPYKSSGESSPSRSGGIGGAGSGSSKSSPKHSSPVHHSSPKGGHHGGGLGFHSPKHGGGATSSASPKHPLHAGSGSTGGGKPSMSALKSAAASGSSPGSKSSTDGGSSSAGSGVGGNGSGAGSSSKEHTRDKERAEKKALQFSSTTLLGSSTSGASLGGMGSTKGKSSALKLKQLDLAAAGAASSLTISLSPGGEPGASSAGALLIDLTGSPVLDSPLQSGGGGGSGLANSASSMLQALQAAKNSRKASAATGGAAGVAVGVGAGSLSAVIDKLKSAQSVDDDGGAVLVLPEMTITQQSASSVTTTVASAGGMGASVNIGSFGALGGGGLKDSSKGGLISAASLANCTTAGIGAAGQLQSSMTNSAPSLTTALTSGKASEYMVKPSSDGIKLTIQNKKGSKSGSKSSGGSSSSKSGLKPGVSSGPMSAKGLQQPPNHTTSFSGAFPSSTKGPHYTSTSSSSSSKTPFQKSNSSPKSTSNPGNSSSSSYSSSGGPKEKGSTGLSGGRSKSSSTASLAGSMLSAAGAGASSASSTLVNPISIMKMLGFPAGGLGNMEGFTKSLDTKFQIPKLSARTAGNAAGGGGGGATAPNLPGGDPASGEGKQSAGRADGRKQKQQQQSSSLLGGASNLRQYSSSTSGGSGNDGAASSGVTSASARLLLSDLLGAAAAAKNASKAGPGGGNAAGGADGGQSALHPLLPNIVQKMFGSDGALLSKSNSSDGSMFPGGGRASPGMLPGGGNRDGFRSSGGSAPGTPTATSALAGGPGGMVLPPFPSPVSHDGDLGASALMRPPSRPSSTISNHSHSSQDGMGEGAAAGAGGGGAGQPGASMASMMMMNALAGGGEQLMAALAAKGGTGGNLLNHSNHLNHHNHNHNHLHNHIGGGAAGGGTGASLKNHPSPASVSVHIVKSPAPSPLPFASPLSSSSAGHGGAGGMGGTGIDDDLMDDALIGISSK
Length2185
PositionMiddle
OrganismAnopheles atroparvus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.263
Instability index50.16
Isoelectric point8.98
Molecular weight214565.46
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07872
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|     843.84|      85|      86|    1169|    1253|       1
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    1-   75 (61.09/ 7.74)	.....................MSSTG.......SAVTG......GS..LP.......ALLMANGGGGPPGlG..........PGG........GkgvGG...............HGG.......K.PD.V.K.......PPSLGSTSGVGGGG.A....GGG.SvpgkvL.................LGG.D.....
  671-  764 (55.65/ 6.14)	G.......AGTST.T..TPLDGGGGG.......LAMNG......TNcQQN.......QQQRALFNGSNGG.GgngttagnnlIVG........G...GN..........lgldfCDM.......LAGRNG.M.......SAA....MGGVMRG.M....GG..........................TVG.QREPPE
  765-  857 (71.73/10.88)	P.......LVGGV.A....KKRRMED.......FCKSP......KS.ESN.......LSGAG.ACGNDGG.G..........IGG........G...TE..ginhqdtsfctapGTG.......GSNVTS.T.......GGDNGRTVPSSSSG.A....GTM.........................LVG.SEQRMQ
 1115- 1207 (72.31/11.05)	M.......TT..T.M..TTTTTSADGgleiiplAATAP......PT.ATA.......I.............G..........VGG........S...LTssvtitpiatvatasSSA.......TSSSTS.S.......SSASKKSSSSSSSG.A....GSH.R.....K.................AGG.DSERSS
 1208- 1295 (111.60/22.62)	S.......TSGKT.E..KKKKRKADD.......TAMGP......PN.KLP.......YKSSGESSPSRSG.G..........IGG........A...GS...........gsskSSP.......KHSSPV.H.......HSSPK..GGHHGGG.L....GFHsP.....K.................HGG.GATSSA
 1296- 1392 (68.05/ 9.79)	SpkhplhaGSGSTgG..GKPSMSALK.......SAAAS......GS.SPG.......SKSSTDGGSSSAGsG..........VGG........N...GS............gagSSS.......KEHTRD.K.......ERAEKKALQFSSTTlL....GS..S.....T.................SGA.SLGGMG
 1393- 1465 (75.25/11.91)	S.......TKGKS.S..ALKLKQLDL.......AAAGA......AS.SLT.......I......SLSP.G.G..........EPG........A...SS...............AGA.......LLIDLT.G.......SPV.LDSPLQSGGG.G....GS...........................GL.ANSASS
 1466- 1564 (56.13/ 6.28)	M.......LQALQ.A..AKNSRKA.S.......AATGG......AA.GV..........AVGVGAGSLSA.V..........IDK........L...KS........aqsvdddGGAvlvlpemTITQQS.A.......SSVTTTVASAGGMG.AsvniGSF.G.....A.................LGG.GGLKDS
 1618- 1690 (69.80/10.31)	S.......DGIKL.T..IQNKK..............G........S.KSG.......SKSSGGSSSSKSG.L..........KPG........V...SS.............gpMSA.......KGLQQP.P.......NHTTSFSGAFPSST.K....GPH.Y.....T.................ST......SS
 1691- 1787 (74.68/11.75)	S.......SSSKT.P..FQKSNSSPK.......STSNP......GN.............SSS.SSYSSSG.G..........PKE........K...GS............tglSGG.......RSKS...S.......STASLAGSMLSAAG.A....GAS.S.....AsstlvnpisimkmlgfpAGG.LGNMEG
 1834- 1923 (68.20/ 9.84)	Q.......SAGRA.DgrKQKQQQQSS.......SLLGG......AS.NLR.......QYSS..ST...SG.G..........SGN........D...GA...............ASS.......GVTSAS.ArlllsdlLGAAAAAKNASKAG.P....GGG.N.....A.................AGGaDGGQSA
 1937- 2043 (59.36/ 7.24)	G.......SDGAL.L..SKS..NSSD.......GSMFPgggrasPG.MLPgggnrdgFRSSGGSAP..................GtptatsalA...GG......pggmvlppfPSP.......VSHDGDlG.......ASALMRPPSRPSST.I....SNH.S.....H.................SSQ.DGMGEG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.10|      17|      17|     625|     641|       2
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  625-  641 (35.41/ 9.18)	NGGPGGGTGSGTGGLPN
 2113- 2129 (31.69/ 7.38)	GGAAGGGTGASLKNHPS
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.43|      15|      19|    1064|    1082|       3
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 1064- 1079 (25.13/ 9.14)	AM.PKESPAKPSPaPGT
 1085- 1100 (22.30/ 7.50)	AItPVAARVGPTP.PGS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      63.23|      14|      19|     916|     929|       4
---------------------------------------------------------------------------
  880-  893 (21.38/ 9.80)	TTTTNFTTAPAMTT
  894-  906 (18.77/ 7.67)	AS.ATTMTTTTIKT
  916-  929 (23.08/11.18)	TTKADTTTSTTISS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.99|      38|    1248|     537|     575|       6
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  480-  513 (41.75/16.47)	.....AAV.FN.QLLAS.CIRTHS..SnraGAGVI....PALEENGTM
  537-  575 (66.57/35.11)	YEESLATVEFDlQNIASISVRIYG..T...GGGGG....DEGEEPGCD
 1788- 1826 (50.66/21.87)	FTKSLDT.KFQ...IPKLSARTAGnaA...GGGGGgataPNL..PGGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.37|      17|      36|     389|     405|       8
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  389-  405 (30.84/13.84)	GIVAGGGGGAPGVELAP
  417-  433 (28.52/12.06)	GLIAHHASGGSVTDLSR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.46|      26|     374|     201|     239|      10
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  196-  234 (32.29/55.54)	ECKMKQQScselvaclqrgdFADFTTqLE.GLASIYQLNA
  235-  261 (37.17/25.04)	EKKIKVNA............FVALQA.LEtDLHALYALSA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.62|      29|      38|     987|    1015|      11
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  987- 1015 (44.23/18.57)	SSSSSSSSSSSSSSSSSSSSSGSDDIEET
 1028- 1056 (45.39/19.32)	SETAAGNDAVSGSNTQLSALAGGADATST
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07872 with Med1 domain of Kingdom Metazoa
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