<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07861

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSADLRIVKLFEEVVEDRNIVPNFDEEEQRKKTEEGYKKIGTLFGAMAPESKEAAIRNYLGYVASVNHQNRVHNYLQVMNRMVALNIIPAKLLCDQLMCSEKLVYKNPCFWIEAFRLIRKVIGGVDYKGVREIMKCCKEKALSFPASVSVNILPQLLELVELIEHIFNRNACLLPAYFIINEIKKTDYQNMHWRVSNLTANFIEEFVSVAQMLSIIGHSAMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDEELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMECSEKEAAQGGQGAAGGTGMNEHEGDQSHTQWIWLHLSSQLIYFVLFQFATFQNIVNTLHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPILKLYDILYPEKEPLPVPDNNNPNCTHQMAPTCIWIHLMKRAQTENYNINRPVPIALRLHFEYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMVGGGQPLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSQAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYVSEPKPPGNIVSGESEELNRALILTLARSMHITGTGNDPQSSAWCKDLLQNIMVNTPHAWPQHTLYCFPPVLNEFFMQHNIPKESKQLLKKTVDEEYRNWASMTNENDIIAHFGMTVNPPLFLCLVFKMIIETDGISPVAYKILERIGARALSTHLRKMCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIITIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTTEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPSLPVYFGNVCLRFLPVLDIIVHRYLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYERKLRDRPQLKKRLVGTVVGSLKDVRPENWALTEAYQAYMMTKESDNVNWVPELSYYINLVPMDGKNIFAGTDWRFNEFPNPPAHALYVTCVELLGLPVGPSVVANSIIDVLVKGYPVVPNGVIHNWANTIGLIMAALPEAYWSVIYERMQEALSSKAMKDWTYRQSPFDMFNFKIVKEAMLDRSYVTVLAIVHSIFHHFGIGQLATITEYVAAQLSSIKEKLKPLVHTEYQLIYLCHVVGPFLHRLSIERARAVADITLMLYELLEQVDKAQPAQPLRYMDPICDLLYHIKYMFVGDTMKTELEAIIRRLRPALQMRLRFITRLNVEEIGVDQNAAAAAAGGGGGAGSAATATGQGVAGAGPGVGPPPGGVAAGAPGATQGVVASGQAAPGKAAGPQQPQQVVGVVGNQNVALQQQLQQQQMGQGIQSHH
Length1455
PositionTail
OrganismAnopheles arabiensis (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.09
Grand average of hydropathy-0.086
Instability index45.47
Isoelectric point7.47
Molecular weight164676.86
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07861
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.94|      17|      17|    1365|    1381|       1
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 1365- 1381 (33.88/18.50)	AGGGGGAGS.....AATATG..QG
 1383- 1406 (25.06/11.93)	AGAGPGVGPppggvAAGAPGatQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.19|      15|      17|    1116|    1130|       2
---------------------------------------------------------------------------
 1116- 1130 (26.56/16.90)	VELL..GLPVGPS.VVAN
 1133- 1150 (19.63/10.31)	IDVLvkGYPVVPNgVIHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.96|      15|      17|      44|      60|       3
---------------------------------------------------------------------------
   45-   59 (25.54/13.03)	GAMAPESKEAAIRNY
   61-   75 (27.41/13.93)	GYVASVNHQNRVHNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     774.11|     264|     318|     470|     786|       4
---------------------------------------------------------------------------
  410-  523 (84.26/32.17)	............................................................................................................................................................................................................................................LYDILY......PEKEP......LPvPDNNNPNCTHQMAPTCiwIHLMKRAQTENYNiNrpvpialrlhfeyLQHLA.....MPSNNPTLFMGSEYRFALLCNA.....YS..TQTDYFSRPMQALIDTILGNSKNPQ
  524-  842 (364.80/328.73)	ANmVGGGQPLPtaplsmRVLDslTIHS.....KMSLIHSIVMHMIKQaqnksSIpNGNNMAPALVETYSRLLVYTEIESlGIKGFLGQLLPQVFKSQAWgilytllemfsyrmHHIHSHYRVQLLTHLHSLASVPHTNqmqLHSCVESTALRL.....IIGLGSVEVQAQLSR............YVSEPKPpgnivsgeseelnralILTLARSMHITGT..GNDPQssaWCKDLLQNIMVN....TPHAWPQHTLYcFP.PVLNEFFMQHNIPKES..KQLLKKTVDEEYR.N...wasmtnendiIAHFG.....M.TVNPPLF.........LCLV.....FKmiIETDGISPVAYKILERIGARALSTH
  855- 1114 (325.06/198.79)	AN.SGGGAHVN......KCVD..TINDmiwkyNIITIDRLVLCLILR.....TL.DGNEAQVSFYIIQLLLLKTTEFRN.RVQEFITINSPEHWKQNNW..............HERHLAFHQKFPEKFAPDESVSHPS...LPVYFGNVCLRFlpvldIIVHRYLEVPTQLSKtldvildhlgslYKFHDRP................ITYLYNTLHYYERklRDRPQ...LKKRLVGTVVGSlkdvRPENWALTEAY.......QAYMM....TKES..DNV.......................nwVPELSyyinlVPMDGKNIFAGTDWRFNEFPNPpahalYV..T........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.06|      14|      44|     330|     344|       5
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  330-  344 (24.75/18.81)	NEHEGdQSHTQWIWL
  376-  389 (27.31/15.57)	NLRRG.RDHLMWVFL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.21|      16|      19|    1234|    1252|       6
---------------------------------------------------------------------------
 1234- 1252 (22.14/20.77)	EYvaaQLSSIKEKLKPLVH
 1254- 1269 (31.07/20.07)	EY...QLIYLCHVVGPFLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.61|      17|      19|    1408|    1426|       7
---------------------------------------------------------------------------
 1408- 1426 (26.61/23.30)	VasGQAAPGKAAGPQQPQQ
 1428- 1444 (29.00/18.22)	V..GVVGNQNVALQQQLQQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07861 with Med23 domain of Kingdom Metazoa
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