Description | Mediator of RNA polymerase II transcription subunit 21 |
Sequence | MADRLTQLQDTVNQQAEHFCNSIGILQQCSVPSKFAGFERTGSQTPQQQVHQQQQLPQQQQQQQQQEDFPQLFSTLISRCAKDIDTLIESLPSEESSIELQVQSLQRLEAENKESAEKLEEIVRKGELLLEKIQAALSDIAQSQLDMQYSS |
Length | 151 |
Position | Middle |
Organism | Anopheles arabiensis (Mosquito) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.719 |
Instability index | 73.28 |
Isoelectric point | 4.49 |
Molecular weight | 17160.85 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | |
GO - Biological Process |
Binary Interactions |
Repeats | >MDP07860 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) EKLEEIVRKGELLLEKIQ 2) QEDFPQLFSTLISRCAKDIDTLIESLPSEESSIEL 3) VHQQQQLPQQQ | 117 66 50 | 134 100 60 |
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