<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07857

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPQPLEQGGAVTSFIPTGQEMAQRQNLIPLGRLIDFIIQRTYHELTVLAELLPRKTDMDRKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMGFLDKQSMLFIDTADMLSRVARETLVHARLPNFHIPAAVEILTTGSYSRLPSVIRDRIVPPDPITPAEKRQTLQRLNQVIQHRLVTGSLLPQLRKFRIENGRVTFKVDHEFEVSLTVMGDAPTVPWRLLDIDFLVEDKETGDGKALVHPLQVNYIHQLIQGRIVDCTDALAEVYTCLHYFCQSLQLEVLYTQTLRLIRDRLDDHIHVDEYVVGSRLTVSYWRELTNKDPKSELGYRLTIQTDPNDAAKQLAILHVPSIGNKEADIADRAVRSDLLSMERLLVHTVYVRSLARLNDVKTELQLFLKDVEYNIQGTPAMLTVPVLNPCLRAEHIYITVDTHTGMLRCHVPKHLDCPIMPEMQHALNNDWSKLQHLISELRYWITQRRCEKTLQHLPAATQDRLPLIYSHTHPIARMGPHKVFIQLYRHANVILIVELKEKKTCPNEMTYTFYLVLVKPSSVEEGQSPDVLSGQPPQPSAAGGPAPGSDAANAAMPKMYLRVLSMIEFDTFVATHGPGTYIDDPCPTSTSGTSVKRKVSPLDNALSAIGPPLKQQKTIYPAYFIPELAHVVAMCDEKLPFVTLAKEFSMRKIPHGGLQVEANATSLVLKLLTLPQPKPPQAPPTPQQQQQQQQQQQQPGTSDAKSSGAGASANEPKTVHVPPIDKQVWNALLKRLLSVSVRAQVNKSNQTRLWTMELVFYGSPLPSLHHKEQGMRRAVYLQYEMQPVESVSKVVDQLLSDWSKIVYLYTLVHEFREQYNNEKYNLPSMVAIKSYSYTNLLLAYGPNKDVSVNICWDTEAKEFRLVFTGGNSAINAHSMMRDQLQAHLNHNYSLAQVVHMLHETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEVRFRGGGLCTIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVFRRRSQSEDDNPPSPVTLEDPSAGAGNNGGGGGGGGGAGGGANTFLSGGTGMRGPQSPRDPGLRFAAPLTPPTSSNPHTPASPHPIGGGGGTGGAGGQGGQGGQGGQQQGHMNNFNMTSPPASHMPHPSPGGGLMPSSPLNAQPSPMAAHSPGPSSLSYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTSHHYTSRVLPARSWAGAIPTTLTYEALDTLCRATPHPQKEVPGPELSPLERFLGSVFMRRQLQRIIHQEESLMAITSNEPGVVVFKADCLQYQVFLNPNHMQSLHLKVDQLPMGPMMDGKPPYQWAAQDLQILEQFFDHRVAAPPYRPAVMTSFTRMLNLPAKVLKDFIQIMRLDLMPELVQGNKWNVQFVLRVPPSATPIVPVGTTTILSHRQKILFFIQITRVPYLPNMEWKDAVTMLLPMVYDMNMNHTTLAERREPMPPQLTSAVSAHLRRFSECSVLLPDECSLFPAVHDLLLTLTLPNEPPAPGQMQMQQLGGVMQPGGGPGVPGGPGGPMGGQIGGPTPQVVPQVGSSPSPMMHSPMQQMGGGGPQPGAYGGMVGGPGGGPQSGGPVGGGPGGPN
Length1640
PositionTail
OrganismAnopheles arabiensis (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy-0.280
Instability index52.14
Isoelectric point8.53
Molecular weight180254.01
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07857
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     369.43|      62|      63|    1060|    1122|       1
---------------------------------------------------------------------------
 1060- 1104 (68.75/25.89)	...........................GAGNNGG.GGGGG.......GGAGGGANTfLSGGT.GMRGPQSPRDPGLRFAAP
 1105- 1152 (89.66/32.13)	LTPPTSSNPHTP......AS..PHPI........gGGGGT.......GGA.GG.....QGGQ.GGQGGQ...QQGHMNNFN
 1153- 1207 (85.63/30.35)	MTSPPAS..HM...........PHPSpGGGLMPS.SPLNA.......QPSPMAAHS..PGPS.SLSYMQSHTD.GSPFAA.
 1538- 1592 (85.38/30.24)	LTLP..NEPPAP......GQmqMQQL.GGVMQPG.GGPGV.......PGGPGGP...M.GGQiGGPTPQVVPQVGS.....
 1593- 1640 (40.02/10.07)	.SPSP..MMHSPmqqmggGG..PQPGaYGG.MVG.GPGGGpqsggpvGGGPGGPN..........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.66|      13|      41|     711|     723|       2
---------------------------------------------------------------------------
  711-  723 (27.07/15.64)	QPKPPQAPPTPQQ
  750-  762 (24.59/13.29)	EPKTVHVPPIDKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      89.26|      16|      41|     141|     157|       3
---------------------------------------------------------------------------
  142-  157 (27.33/18.05)	TTGSYSRLPSVIRDRI
  168-  183 (26.89/12.12)	KRQTLQRLNQVIQHRL
  185-  197 (17.85/ 7.43)	.TGSL..LPQLRKFRI
  488-  500 (17.18/ 6.80)	...TLQHLPAATQDRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.33|      39|     566|     237|     279|       8
---------------------------------------------------------------------------
  237-  279 (61.40/48.53)	KETGDGKALVhpLQvnYIHQLIQ..GRIVD..CTD..ALAEVYTCLHYF
  806-  850 (54.93/31.27)	KEQGMRRAVY..LQ..YEMQPVEsvSKVVDqlLSDwsKIVYLYTLVHEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.71|      18|      30|      60|      77|       9
---------------------------------------------------------------------------
   60-   77 (30.75/22.21)	DRKIEIYNFSASTRQLFI
   93-  110 (30.96/22.41)	DKSAKIMGFLDKQSMLFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.05|      17|      21|    1344|    1364|      11
---------------------------------------------------------------------------
 1344- 1364 (30.14/25.63)	LKVdqlpMGPMMDGK...PPYQWA
 1368- 1387 (26.90/12.68)	LQI....LEQFFDHRvaaPPYRPA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07857 with Med14 domain of Kingdom Metazoa
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