<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07853

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDTWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMKDLIPKLHEHYHQGPLQEKPSSGGAGSSGGLGSGASGLGLGSGAGGTNAVTIPPPLSSPAGSMHSPAGGNPVVGGSMHAQQQQQQQQQPISPQEEQRIAQKQWNYSTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLYDLVQSERFCRRLAYAVSKKLAQLINQMAESHNINLSSPEPQDASGKQPSVEAPESKSEKQNDKPSKEGTVGIVAQPADSKPPKVNPYEMIFTEYLQCSHHRDVILQLSSILQVITLECPTALVWCGVGETRSSSVLSGSPLDHLPVAPSALPIPTRYEKSNEDIRRQLFEAEESIKVRSRHAESRWCIDKWQTAAGNASLKILATLDALDGHCFDRMDSNNSLDSLYSKIFPPFQVQPLKPAESASAAGGSGGSGTGNMPSGLAAVDGKDAATKQFEYNVEQDSSIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVLTALENDSYTNNLNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLDEAGSPQNKSQFTNLVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDSQGICNAGLGTGPISNKPATSSSPNGGGGVEDDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPSVTGLGKAESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFESTSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAIGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVELQLIGKSSMALVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKARPQQEPFHNAYPKIKQALYTPLQPTPSAHTYNPQFMLDIITNPRRGGKIESGWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHKVSSIFGSGKRSGLNTPVHPGSTPKSMAGSGDLSHILGTSDLSILGNPDESMLDVSMIELGELSPTASARLYSSRQQNSHLNQDNATSLSDFAQHVLRQICSQEWVLERCLQHAEELCQHGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELDQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCSSPDLSNWLDMVARAAIDVFRVNEFILNSPDVKQEKVKPSTWLVAPLVSKLPSAVQGRILKVSGQVLESTSMFSKHKDGNGGNNSSNNNSHNHGANSNSSVSSNGSTFGSKQSAQLNHQPFLGLVLTCLKGQDEQKEGLLQSLYSQLSQFLQNRDQSLETIGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVLTCDSAGSSTDAKGNKIAIDSIEKKNGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEVDPLPDKLKDDMKADTPSSDQSPAPSTGSKKSKTTTRKRKTKATAAAQVQQSQPQQPIMPAIVPQPAAGPQQMQQMQQQQQQQQQQQQQQQQHQQHQQQQQQQQMQQQQTLQQQQHLQQQQQQLHLQQQQAQQQQQLQQQQQLQQLQQQQQQQLQQQQQQQNQMMMQQQQQPNIPQQQQSALQQQQLGSQQGQQQQQQQVTMTPQQTLQQMQNNSMGGMQMGGPMSSMNQQHMQQQYGQANPAQLVGQGNMGGMQTGMGGLGAGMGGGMMNQQQQQQQQQQQQPPQQQQPQQAQQAQQAQQAQQQQPQGNPNMGFVGNVNPMAQLAQQQGGNQQWGGYGSLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQSQVQQQQQTPQQGQQASQQQGPQQGPQQGAQQGPQTQQQLQQQQQQQQMFYSGMGQATMNRFDRPQLNTNSKQALSNMLRSKLPINAGHPASFMQQQQQQQQAQQQQAQRNPQQPFLRGPLRAGMPGNPIVGAQAGMGPMNPAMAGGTAGIGTAGGGAVMGAQGMGAGGMMGAQQTAQGQQGAGGIMNQTTPAMMGTTGGSIMSQSGGSMIQTGMMNPQQNPALVGQGMGGSGGLGGASGMAGNSGMGASAGGMGGTSGGGMVTSGGMVTGGMGSAGIGNTAPMGAGGQGGGMGGNAGMPNAAGMGNPAMGNPGMGMQNMQQSGNMQGGGMFQGQNVPYQNVNQNYPNYGNQGMGQQSGQGGGMMGNFNPMAQQQRNTQAEFLAQQRAAMAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNMPQNQQQQFQQQRMRLIMQQHSGMGQGGNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
Length2830
PositionKinase
OrganismAnopheles arabiensis (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.633
Instability index56.86
Isoelectric point6.84
Molecular weight309630.54
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07853
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     337.64|      17|      17|    2280|    2296|       1
---------------------------------------------------------------------------
 2026- 2042 (39.47/11.13)	Q.......QQQQH.QQHQQQQQQQ..Q
 2043- 2060 (31.25/ 7.00)	M.......QQQQTlQQQQHLQQQQ..Q
 2061- 2080 (33.17/ 7.96)	Q....lhlQQQQA.QQQQQLQQQQ..Q
 2081- 2097 (34.60/ 8.68)	L.......QQLQQ.QQQQQLQQQQ..Q
 2120- 2136 (32.19/ 7.47)	L.......QQQQL.GSQQGQQQQQ..Q
 2227- 2243 (29.88/ 6.31)	Q.......PQQAQ.QAQQAQQAQQ..Q
 2272- 2295 (35.61/ 9.19)	QwggygslQQQQQ.QQQQQQQQQQ..Q
 2296- 2313 (38.01/10.39)	Q......qQQQQQ.QQQQQQQQQQ..Q
 2329- 2345 (31.54/ 7.14)	Q.......QQQTP.QQGQQASQQQ..G
 2419- 2437 (31.94/ 7.35)	Q.......QQQQQ.QQAQQQQAQRnpQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|     549.38|      48|      49|    2462|    2509|       2
---------------------------------------------------------------------------
 1990- 2019 (48.29/ 9.46)	SQPQ...................Q.............................PIMP.....................A......................IVPQPAA................G..PQ.QMQ....Q..MQ.......................................Q.QQQ
 2114- 2171 (45.76/ 8.58)	QQQQsalqqqqlgsqqgqqqqqqQV......................T......MTP............................QQT.......L.QQMQNNSMG..................G..MQmGGP....MssMN.......................................Q.QHM
 2172- 2213 (67.36/16.04)	QQQ................................................yGQANP.....................A..QlvgQGNMG....GMQTGMGG..LGA.................G..MG..GG....M..MN.......................................Q.QQQ
 2214- 2317 (40.49/ 6.76)	QQQQ...................QQ............................QQPPqqqqpqqaqqaqqaqqaqqqqP.......QGNP....NMGFVGNVNPMAQL................A..QQ.QGG....NqqWGgygslqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqQ.QQQ
 2318- 2383 (40.40/ 6.73)	QQQQ...................QTqsqvqqqqqtpqqgqqasqqqgPQQ..GPQQG.....................A..Q...QG..PqtqqQLQQQQQQQQMFYS................G..MG.QAT....M................................................
 2462- 2500 (68.16/16.32)	....................................................GPMNP.....................A..M...AGGTA....GIGTAGGGAVMGAQ................G..MG.AGG....M..MG.......................................A.QQT
 2501- 2545 (63.80/14.82)	AQGQ...................QG......................AGGimNQTTP.....................A..M.............MGTTGG.SIMSQS................GgsMI.QTG....M..MN.......................................P.QQN
 2547- 2587 (44.65/ 8.20)	ALVG...................QG......................MGG.sGGLGG.....................AsgM...AGNS.....GMGASAGG..MG..................G..TS.GGG....M..V.............................................
 2620- 2650 (43.79/ 7.90)	NAGM...................PN......................AAG.mG..NP.....................A..M.....GNP....G.........MGMQ................N..MQ.QSG....N..M.............................................
 2651- 2695 (45.89/ 8.63)	.......................QG......................GGMfqGQNVP...................yqN..V...NQNYP....NYGNQG....MGQQ...............sG..QG..GG....M..MG.......................................NfNPM
 2734- 2790 (40.79/ 6.87)	........................G......................VNQ..GAVPP....................yP..R...QGGKP....GV...GGNMPQNQQqqfqqqrmrlimqqhsG..MG.QGGnaqgM..M............................................Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.93|      17|      19|    1390|    1406|       3
---------------------------------------------------------------------------
 1368- 1389 (23.63/14.29)	SIFGSGKRSGLntpvhPGSTPK
 1390- 1406 (29.41/20.37)	SMAGSGDLSHI.....LGTSDL
 1407- 1420 (18.90/ 9.33)	SILGNPDES.M.....LDVS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.83|      11|      24|    2791|    2802|       5
---------------------------------------------------------------------------
 2791- 2802 (17.31/ 8.97)	NQGQGMStQQTP
 2814- 2824 (22.52/ 8.60)	NQNNMMG.QQYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.78|      13|      24|    1702|    1717|       6
---------------------------------------------------------------------------
 1702- 1717 (15.20/20.46)	LQNRdQSLetIGGIED
 1728- 1740 (24.57/15.34)	LQLR.YSL..VGGLFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.26|      28|      28|    1747|    1774|       7
---------------------------------------------------------------------------
 1747- 1774 (46.31/30.31)	TSTTDW..AILFAQLISQGVIDLSNNSELF
 1775- 1804 (40.95/25.89)	TTTLDMlaTLIHSTLVSDSQTERDENKKLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.51|      15|      15|    1625|    1639|       8
---------------------------------------------------------------------------
 1625- 1639 (26.78/14.86)	SKHKDGNGGNNSSNN
 1641- 1655 (25.73/13.95)	SHNHGANSNSSVSSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.44|      15|      19|    2388|    2402|      11
---------------------------------------------------------------------------
 2388- 2402 (26.03/14.01)	RPQLNTNSKQALSNM
 2404- 2418 (27.41/15.19)	RSKLPINAGHPASFM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.66|      17|      19|    1853|    1869|      13
---------------------------------------------------------------------------
 1853- 1869 (28.48/17.30)	GNKIAI...DSIE.KKNGLRL
 1870- 1890 (21.18/10.88)	GDKQRVsvwDLLEgHKNPAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.60|       9|      28|    1924|    1933|      14
---------------------------------------------------------------------------
 1924- 1933 (15.05/12.33)	PSSyYYEPLP
 1955- 1963 (18.55/ 9.05)	PSS.DQSPAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07853 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQGMGAGGMMGAQQTAQGQQGAGGIMNQTTPAMMGTTGGSIMSQSGGSMIQTGMMNPQQNPALVGQGMGGS
2) DLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPSVTGL
3) GMGSAGIGNTAPMGAGGQGGGMGGNAGMPNAAGMGNPAMGNPGMGMQNMQQSGNMQGGGMFQGQNVPYQNVNQNYPNYGNQGMGQQSGQGGGMMGNFNPMAQQQRNTQAEFLAQQRAAMAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNMPQNQQQQFQQQRMRLIMQQHSGMGQGGNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
4) HEHYHQGPLQEKPSSGGAGSSGGLGSGASGLGL
5) HNINLSSPEPQDASGKQPSVEAPESKSEKQNDKPSKEGTVGIVAQPAD
6) LPLPPEEVDPLPDKLKDDMKADTPSSDQSPAPSTGSKKSKTTTRKRKTKATAAAQVQQSQPQQPIMPAIVPQPAAGPQQMQQMQQQQQQQQQQQQQQQQHQQHQQQQQQQ
7) MFSKHKDGNGGNNSSNNNSHNHGANSNSSVSSNGSTFG
8) MNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKH
9) QQQQQQQVTMTPQQTLQQMQNNSMGGMQMGGPMSSMNQQHMQQQYGQANPAQLVGQGNMGGMQTGMGGLGAGMGGGMMNQQQQQQQQQQQQPPQQQQPQQAQQAQQAQQAQQQQPQGNPNMGFVGNVNPMAQLAQQQGGNQQWGGYGSL
10) SGAGGTNAVTIPPPLSSPAGSMHSPAGGNPVVGGSMHAQQQQQQQQQPISPQEEQRI
11) TQSQVQQQQQTPQQGQQASQQQGPQQGPQQGAQQGPQTQQQLQQQQQQQQMFYSGMGQATMNRFDRPQLNTNSKQALSNMLRSKLPINAGHPASFMQQQQQQQQAQQQQAQRNPQQPFLRGPLRAGMPGNPIVGAQAGMGPMNPAMAGGTAGIGTAGGGA
2486
821
2596
194
375
1932
1623
1
2131
228
2323
2556
856
2830
226
422
2041
1660
35
2279
284
2482










Molecular Recognition Features






MoRF SequenceStartStop




1) GGYGSLQQ
2) IMPAIV
3) MNMRPLKRPRLGPPDVY
2274
1996
1
2281
2001
17