<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07851

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFHKARNKDEYLGFVARLILHVREMNTKHKNQQNAAAAAAAAAQQAQQDGGGNSSQQGGGGGGGGSGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGAGQASNLLHSLRPQMQMGGMGGPMQGNRVGMGPGNQMGGMMGGPNQMQGPGAGMVGGMPGQMGVGMGPGGMSGGKIVGMGGQQQQMAQLNAMQVNQMQQAQQQQQQQQQQQGGMSQPQQQQQQQQQQQGGIAQGQGGPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQNAMGGQQMGSVGGTMNAGNQMGQMVGANAGMNPQAMGMASNQVVRQQQLQQQGMGQVQMGLGPGQMGQLSAGVQGGVGHGGPGPNMGQVQQQVVVQQQQQQQQQQQQHQQHQQLQQHLQQHPQQHQQMQQHQQQMQQQQQQQQQQQHQPQLQQQQMQQHQQHQQMQQHQQHQQHQQLAQQHGQHPQQHPQQQQQQLQQLQQHGHPQIQQQHQQQQVLLNAMGQGPGVGPGVGSISGPIGGPGGPGVTLQQQAMQQQQQAGGMGPGAGPNQMNPGVAMGPGGVVGPVGGGGVMGPGPNQMLGAGGAGGPGAGQQGNFVGMGANAMVRKPPEMMPGGNVYPGSGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMGGVAQRSTIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYRALTKYIEPLKRMIAKMENDDIDKIAKMKRLLEILSNPSVRIPLETLHKCEAALTSQLGSIRETPTNNPLVEAVSSSLQAATGNHTLQRTFRPCLEALFGPDIKNLPPPAKQSRLALDDTGAAGGTGGGVTTGGATTTTTSTTTAAATTGSASSTTSTTASSTTAPQEIPHILQGEIARLDQKFKVSLDQCAISGTRTIKLICWLDDKNLPCVPPVAVTIPEDYPSTAPSCSLIEQEYNATPFLILVQKSLMARICKLPGLFTLSHLLDTWEMSVRQACSPNPTIVAPTGTSVLLGM
Length1047
PositionTail
OrganismAnopheles arabiensis (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.02
Grand average of hydropathy-0.663
Instability index56.18
Isoelectric point9.18
Molecular weight109653.20
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07851
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     504.67|      48|      48|     412|     459|       1
---------------------------------------------------------------------------
  206-  257 (60.00/ 6.53)	G..Q......MGVGM......GPGGMSGGkivgMG...G...QQQQM...AQ........LNamqvNQMQQaQQQQQQQQQQQ
  264-  307 (74.94/10.39)	QQQQ......QQQQQ......QQGGIAQG.....Q...GGP..VQQMgvgPG........GP....NQMN.....PMVMGQIQ
  308-  362 (65.95/ 8.07)	AQLQ......NQNAM......GGQQMGS.....VG...GTMNAGNQM...GQmvganagmNP....QAMGM.ASNQVVRQQQL
  363-  413 (61.90/ 7.02)	QQQG......MGQVQmglgpgQMGQLSAG....VQggvGHGGPGPNM...GQ........VQ....QQVVV.....QQ..QQQ
  414-  461 (92.50/14.92)	QQQQ......QQQHQ......QHQQLQQH....LQ...QHPQQHQQM...QQ........HQ....QQMQQ.QQQQQQQQQHQ
  465-  510 (81.78/12.15)	QQQQ......MQQHQ......QHQQMQQH.....Q...QH.QQHQQL..aQQ........HG....QH.PQ.QHPQQQQQQLQ
  511-  564 (67.59/ 8.49)	QLQQhghpqiQQQHQ......QQQVLLNA....MG...QGPGVGPGV...GS........IS....GPIGG.PGGPGVTLQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     167.21|      25|      28|     573|     597|       2
---------------------------------------------------------------------------
  164-  183 (36.72/ 7.71)	GG.MG...GPMQGNR.VGMGPGNQM.
  573-  597 (56.10/16.28)	GG.MGPGAGPNQMNPGVAMGPGGVVG
  602-  620 (34.91/ 6.91)	GGvMGP..GPNQM.....LGAGGAGG
  682-  704 (39.47/ 8.93)	GA.HGPPSHPGQMIPSPALIPSP..N
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.61|      21|      30|      99|     128|       3
---------------------------------------------------------------------------
   99-  119 (42.54/ 8.36)	GGGGGGGGSGMPDPINALQNL
  137-  157 (39.07/16.16)	GGPMGGQMGGAGQASNLLHSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.82|      28|      30|     621|     650|       4
---------------------------------------------------------------------------
  632-  660 (49.04/14.31)	MGANAMVRKPPEMMPGGNV.yPGSG..GAVRS
  661-  680 (34.23/ 7.73)	VTPNNFLRQS....PSPSV..PSPV......G
  707-  734 (29.56/ 9.57)	MGGVAQ.RSTIGQSPGGSLntP..GqpGGAV.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.82|      12|      15|     881|     893|       6
---------------------------------------------------------------------------
  881-  893 (18.34/14.28)	TTGGAtTTTTSTT
  898-  909 (21.48/11.56)	TTGSA.SSTTSTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.58|      14|      15|     817|     830|       7
---------------------------------------------------------------------------
  817-  830 (21.96/13.41)	NNPLVEAVSSSLQA
  834-  847 (25.62/16.87)	NHTLQRTFRPCLEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.11|      16|      16|     757|     772|       8
---------------------------------------------------------------------------
  757-  772 (26.96/24.81)	IEPLKRMIAKMENDDI
  775-  790 (25.15/22.57)	IAKMKRLLEILSNPSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07851 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFH
2) PPAKQSRLALDDTGAAGGTGGGVTTGGATTTTTSTTTAAATTGSASSTTSTTASSTTAPQE
3) QGMGQVQMGLGPGQMGQLSAGVQGGVGHGGPGPNMGQVQQQV
4) QQQQHQQHQQLQQHLQQHPQQHQQMQQHQQQMQQQQQQQQQQQHQPQLQQQQMQQHQQHQQMQQHQQHQQHQQLAQQHGQHPQQHPQQQQQQLQQLQQHGHPQIQQQHQQQQVLLNAMGQGPGVGPGVGSISGPIGGPGGPGVTLQQQAMQQQQQAGGMGPGAGPNQMNPGVAMGPGGVVGPVGGGGVMGPGPNQMLGAGGAGGPGAGQQGNFVGMGANAMVRKPPEMMPGGNVYPGSGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMGGVAQRSTIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREK
5) VREMNTKHKNQQNAAAAAAAAAQQAQQDGGGNSSQQGGGGGGGGSGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGAGQASNLLHSLRPQMQMGGMGGPMQGNRVGMGPGNQMGGMMGGPNQMQGPGAGMVGGMPGQMGVGMGPGGMSGGKIVGMGGQQQQMAQLNAMQVNQMQQAQQQQQQQQQQQGGMSQPQQQQQQQQQQQGGIAQGQGGPVQQMGVGPGGPNQMNPMVMGQIQAQLQNQNAMGGQQMGSVGGTMNAGNQMGQMVGANAGMNPQAMGMASNQVVRQQQLQ
1
858
365
417
63
44
918
406
749
363










Molecular Recognition Features






MoRF SequenceStartStop




NANANA