<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07849

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSASGTAAVSGGSLPALLMANGGGGGGSGGPGGGPGGGKGIGKPDIKPPGGGGPSAGGTGTAGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFQEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSLQHYADVHAQLHKAPLGVVQKRRGGHPMRLTYFVAPYELLDLTTRTMNVLSAELIAQERIGCSVAVVLEASSANKLQIQPLLVVNAGSGSAASVLQPVYTPIEKHNSTSLPATFVLRLSKPMPLNSAMMRAIRGIVGGSGAGEQQQAGEGSSGGGGLPGSLLGLIAHHASAGSVTDLAKGLLVSLPDQYHCYFLTDNPSLRGMMVSSIPFTEPQHVPKILTYLRQQAVFNQLLSSCIRTNAPGGGGGRPSALQQLLDGGSVHTIENGTTGGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIANIAVRIYCSEGETSDEHTVERISAVLQRCMSIPVTLRALMKAWEEEHEQKFKPNVLGSSTVSLGGAGGGPGGGGGGGGGAGGAAPGLNNGGDGTGPAGGLTGTGDDGTMNGFNLSSLGGPGPAVDGSGAGGGGGSAATNGTAAAQQQRGLMNGEGNGLTVSGGGSLGLDFCDMLTERNGSGLGAAAAIGIVGGRGPGGMVAREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVGGGGGGGACDAVGTEKANIGAAGVAGATGATNSSSITTTTITSQDVGAAASGATGAGNSSEQRLQTGGATEEDTGGLPLFGETVPAAAGTDAKGSSLGGTTTTNAMISAKNEPPSVLPTGGGDGDTATGATMPLQSSSSSSLSSLSSAGFSLAGGPLAGEPAPDRPCPGTLLLESLDFSALEPDAVKRSTGAGQPTKRRRSSSSSSSSSSSSSSSSSSSSSTSAASDELEESVDLVEAEMSSFFAETNNTQPVAAIAKASFGSPSGKPALGAVSPIASKVVSPSGGAGLEKTPLPTISGSGLEIIPLATSAGTVAASGFPSPSVTSAPIAVPQSNATGSTSSTTATSSSTVKKSSSSSGGGSGSHRKTSDSSERTSSSKSEKKKKRKTDDSAMGPPNKLPYKSSGESSPHRSGGGVGGSSLSTSKSSPKHSSPVHHSSPKHSGSGGPLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGSKSSDVGGGGGGTSGASISTAGSSSKERDKERSEKKALQFGTTNTATGSSSLTATSAAGSSSSSSSGGRSKNSSLKLKQLDLAAGSSMSISMAAGIGDAGSSSPVAPMIDLTGPVPGAAAALGGLGLPGPGMTTASSMLQALQAAKNRKTPTAAGGSTGLGGSLSAVIDKLKSAQSADDEAVLILPEMTITQQTTSLAAGTGGIGTGVNIGGFGGLKESAKSGSGLLPSGGTSSLSNCVSSTAGIAGAALTQSSSVTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSNKSSSSSSNSGSGSKSSNKSGLKSGVSSGPVSSKQQQQQQQQQQQSNHTTSFSGAFPSSTKSPHYTSSTSSSSKAPFQKSNSFGSLGGSGGTGMKASKVSSPKSTSNPASSSSSSAYSSKEKGGSTSGRSKSSSASSLTGAMLTGATGGTGSGTGSSSSALVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNSGASGTASTGSSESGETGSKSAKDPAARKQKQQTPVTTAAPSVGSSPVRQFSSTSPSGEASARLLSDLLGAAAKSSNKMAPGTSAASVDGTAGAGGGGGAGLHPLLPNIVQKMFGSDGSLQTKSNSSDGSMFPTAGRASPGMLSGSASRDGFRSGGGSGSAPGTPTTTSSMVLPPFPSPISGGASNDGDVGSGTLMRPPSRPSSTISNHSHSSQDGIGGGSGNSGDAVAGSTPAVASMASMMMMNAMSAAAGGGQSPASTGGSLPLDSTSTQQLIAALAAKSGVLPPPPPNNLLNNHHSNHLNNHVVGGAAALNNLPSPASVSVHLVKSPAPSPLPFASPHSNASSTHAAGAAGLDDDLMDEALIGIGSK
Length2154
PositionMiddle
OrganismAnopheles arabiensis (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.266
Instability index53.73
Isoelectric point9.06
Molecular weight211851.38
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07849
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     761.39|      93|     143|    1334|    1426|       9
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  695-  850 (51.33/ 6.10)	GGGSAATngtaaaqqqrglmngegngltvsgggSLGLDFCDmLTerNG.SGLGA..........................AAAIG.IvGGRGPGG....MVAreP...................PEPLAGGAAkkrrmedfckspksdsnlSVGGGG..G..GGACD....AVG.............tekanigaagvaGATGatnSSSITTTTITsqdvGAAASGAT
  944- 1015 (59.67/ 8.87)	AG...................................................F..........................SLAGG...PLAGEPA....P......................D..RPCPG.TL..................LLESLDFSAlePDAVK....RST..................gagqptkRRRS...SSSSSSSSSS....SSSSSSSS
 1176- 1269 (65.59/10.83)	SEKKK..............................KRKTDD........SAMGP..........................PNKLP.Y.KSSGESS....P............................HRSG.....................GGVG..G..SSLST....SKSspkhsspvhhsspkhsgsggplgfhSPKH...GSSVSPKHPL....HSGGSSTG
 1270- 1355 (81.57/16.13)	GGKPSMS..........................ALKSAA....A..SG.SS................................................PGS..K...............SSDVGG...........................GGGGTSG..ASIST....AGS....sskerdkersekkalqfgttnTATG...SSSLTATSAA....GSSSSSSS
 1356- 1463 (124.20/30.27)	GGRSKNS..........................SLKLKQLD.LA..AG.SSMSI..........................SMAAG.I.GDAGSSS....PVA..P...............MIDLTGPVPGAAA..................ALGGLGLPG..PGMTT....ASS..........mlqalqaaknrktptAAGG...STGLGGSLSA....VIDKLKSA
 1464- 1557 (76.57/14.47)	QSADDEA..........................VLILPEMT.IT..QQ.TT.............................SLAAG.T.GGIGTGV....NIG..G...............F....GGLKESAK..................SGSGL.LPS..GGTSS....LSN...............cvsstagiagAALT...QSS.SVTSAP....SLTAALTS
 1558- 1698 (53.50/ 6.82)	G...KAS..........................EYMVK.........P.SSDGIkltiqnkkgsnkssssssnsgsgsksSNKSG.L.KSGVSSG....PVS..SkqqqqqqqqqqqsnhTTSFSGAFPSSTK..................S......PH..YTSST....SSS...skapfqksnsfgslggsggtgmKASK...VSSPKSTSNP....ASSSSSSA
 1709- 1793 (78.98/15.27)	SGRSKSS..........................S............A..SSLTG..........................AMLTGaT.GGTGSGT....GSS..S...............SA.LVNPI....S..................IMKMLGYPT..GSMGNmegfAKS.......................ldTKFQ...IPKLSARSNS....GASGTAST
 1853- 1946 (82.42/16.41)	LGAAAKS..........................S....N.K.MA..PGtSAASV..........................DGTAG.A.GGGGGAG..lhPLL..P..........nivqkMFGSDGSLQTKSN..................SSDGSMFPT..AG.RA....SPG.........................MLSG...SAS.RDGFRS....GGGSGSAP
 1947- 2044 (87.55/18.12)	GTPTTTS..........................SMVLPPFP........SPIS...........................GGASN.D.GDVGSGTlmrpPSR..P...............SSTISNHSHSSQD..................GIGG.GSGN..SGDAV....AGS.................tpavasmaSMMM...MNAMSA.AAG....GGQSPAST
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.32|      16|      20|    2089|    2107|      11
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 2089- 2105 (24.49/ 9.40)	HVVGGAAAlNNLP..SPAS
 2109- 2126 (24.83/ 8.21)	HLVKSPAP.SPLPfaSPHS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.04|      24|      25|     642|     665|      12
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   11-   30 (31.79/ 6.55)	..GGSLPALLMAN.GGGG.....GGSGG
  642-  665 (45.98/13.11)	GAGGAAPGLNNGG.DGTGPA...GGLTG
  667-  694 (33.27/ 7.23)	GDDGTMNGFNLSSlGGPGPAvdgSGAGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.50|      17|      20|     331|     350|      13
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  334-  350 (28.54/21.40)	QPLLVV....NAGSGSAASVL
  351-  371 (24.96/ 8.46)	QPVYTPiekhNSTSLPATFVL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.17|      12|      20|     430|     441|      15
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  430-  441 (20.88/11.38)	TDLA..KGLLV.SLP
  450-  464 (15.28/ 6.18)	TDNPslRGMMVsSIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.40|      19|      20|     122|     141|      16
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  122-  141 (29.02/23.57)	LQKtLDSM..QYCIKVT.TRQGL
  142-  163 (22.38/12.14)	VER.LDCLtrQLGLKLSeDTSGL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07849 with Med1 domain of Kingdom Metazoa
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