<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07849

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSASGTAAVSGGSLPALLMANGGGGGGSGGPGGGPGGGKGIGKPDIKPPGGGGPSAGGTGTAGKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFQEMSKSVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPAGGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLSLQHYADVHAQLHKAPLGVVQKRRGGHPMRLTYFVAPYELLDLTTRTMNVLSAELIAQERIGCSVAVVLEASSANKLQIQPLLVVNAGSGSAASVLQPVYTPIEKHNSTSLPATFVLRLSKPMPLNSAMMRAIRGIVGGSGAGEQQQAGEGSSGGGGLPGSLLGLIAHHASAGSVTDLAKGLLVSLPDQYHCYFLTDNPSLRGMMVSSIPFTEPQHVPKILTYLRQQAVFNQLLSSCIRTNAPGGGGGRPSALQQLLDGGSVHTIENGTTGGLLVFEVSALSCQNITVSLIHPYEESLATVEFDLQNIANIAVRIYCSEGETSDEHTVERISAVLQRCMSIPVTLRALMKAWEEEHEQKFKPNVLGSSTVSLGGAGGGPGGGGGGGGGAGGAAPGLNNGGDGTGPAGGLTGTGDDGTMNGFNLSSLGGPGPAVDGSGAGGGGGSAATNGTAAAQQQRGLMNGEGNGLTVSGGGSLGLDFCDMLTERNGSGLGAAAAIGIVGGRGPGGMVAREPPEPLAGGAAKKRRMEDFCKSPKSDSNLSVGGGGGGGACDAVGTEKANIGAAGVAGATGATNSSSITTTTITSQDVGAAASGATGAGNSSEQRLQTGGATEEDTGGLPLFGETVPAAAGTDAKGSSLGGTTTTNAMISAKNEPPSVLPTGGGDGDTATGATMPLQSSSSSSLSSLSSAGFSLAGGPLAGEPAPDRPCPGTLLLESLDFSALEPDAVKRSTGAGQPTKRRRSSSSSSSSSSSSSSSSSSSSSTSAASDELEESVDLVEAEMSSFFAETNNTQPVAAIAKASFGSPSGKPALGAVSPIASKVVSPSGGAGLEKTPLPTISGSGLEIIPLATSAGTVAASGFPSPSVTSAPIAVPQSNATGSTSSTTATSSSTVKKSSSSSGGGSGSHRKTSDSSERTSSSKSEKKKKRKTDDSAMGPPNKLPYKSSGESSPHRSGGGVGGSSLSTSKSSPKHSSPVHHSSPKHSGSGGPLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGSKSSDVGGGGGGTSGASISTAGSSSKERDKERSEKKALQFGTTNTATGSSSLTATSAAGSSSSSSSGGRSKNSSLKLKQLDLAAGSSMSISMAAGIGDAGSSSPVAPMIDLTGPVPGAAAALGGLGLPGPGMTTASSMLQALQAAKNRKTPTAAGGSTGLGGSLSAVIDKLKSAQSADDEAVLILPEMTITQQTTSLAAGTGGIGTGVNIGGFGGLKESAKSGSGLLPSGGTSSLSNCVSSTAGIAGAALTQSSSVTSAPSLTAALTSGKASEYMVKPSSDGIKLTIQNKKGSNKSSSSSSNSGSGSKSSNKSGLKSGVSSGPVSSKQQQQQQQQQQQSNHTTSFSGAFPSSTKSPHYTSSTSSSSKAPFQKSNSFGSLGGSGGTGMKASKVSSPKSTSNPASSSSSSAYSSKEKGGSTSGRSKSSSASSLTGAMLTGATGGTGSGTGSSSSALVNPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNSGASGTASTGSSESGETGSKSAKDPAARKQKQQTPVTTAAPSVGSSPVRQFSSTSPSGEASARLLSDLLGAAAKSSNKMAPGTSAASVDGTAGAGGGGGAGLHPLLPNIVQKMFGSDGSLQTKSNSSDGSMFPTAGRASPGMLSGSASRDGFRSGGGSGSAPGTPTTTSSMVLPPFPSPISGGASNDGDVGSGTLMRPPSRPSSTISNHSHSSQDGIGGGSGNSGDAVAGSTPAVASMASMMMMNAMSAAAGGGQSPASTGGSLPLDSTSTQQLIAALAAKSGVLPPPPPNNLLNNHHSNHLNNHVVGGAAALNNLPSPASVSVHLVKSPAPSPLPFASPHSNASSTHAAGAAGLDDDLMDEALIGIGSK
Length2154
PositionMiddle
OrganismAnopheles arabiensis (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.266
Instability index53.73
Isoelectric point9.06
Molecular weight211851.38
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07849
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     761.39|      93|     143|    1334|    1426|       9
---------------------------------------------------------------------------
  695-  850 (51.33/ 6.10)	GGGSAATngtaaaqqqrglmngegngltvsgggSLGLDFCDmLTerNG.SGLGA..........................AAAIG.IvGGRGPGG....MVAreP...................PEPLAGGAAkkrrmedfckspksdsnlSVGGGG..G..GGACD....AVG.............tekanigaagvaGATGatnSSSITTTTITsqdvGAAASGAT
  944- 1015 (59.67/ 8.87)	AG...................................................F..........................SLAGG...PLAGEPA....P......................D..RPCPG.TL..................LLESLDFSAlePDAVK....RST..................gagqptkRRRS...SSSSSSSSSS....SSSSSSSS
 1176- 1269 (65.59/10.83)	SEKKK..............................KRKTDD........SAMGP..........................PNKLP.Y.KSSGESS....P............................HRSG.....................GGVG..G..SSLST....SKSspkhsspvhhsspkhsgsggplgfhSPKH...GSSVSPKHPL....HSGGSSTG
 1270- 1355 (81.57/16.13)	GGKPSMS..........................ALKSAA....A..SG.SS................................................PGS..K...............SSDVGG...........................GGGGTSG..ASIST....AGS....sskerdkersekkalqfgttnTATG...SSSLTATSAA....GSSSSSSS
 1356- 1463 (124.20/30.27)	GGRSKNS..........................SLKLKQLD.LA..AG.SSMSI..........................SMAAG.I.GDAGSSS....PVA..P...............MIDLTGPVPGAAA..................ALGGLGLPG..PGMTT....ASS..........mlqalqaaknrktptAAGG...STGLGGSLSA....VIDKLKSA
 1464- 1557 (76.57/14.47)	QSADDEA..........................VLILPEMT.IT..QQ.TT.............................SLAAG.T.GGIGTGV....NIG..G...............F....GGLKESAK..................SGSGL.LPS..GGTSS....LSN...............cvsstagiagAALT...QSS.SVTSAP....SLTAALTS
 1558- 1698 (53.50/ 6.82)	G...KAS..........................EYMVK.........P.SSDGIkltiqnkkgsnkssssssnsgsgsksSNKSG.L.KSGVSSG....PVS..SkqqqqqqqqqqqsnhTTSFSGAFPSSTK..................S......PH..YTSST....SSS...skapfqksnsfgslggsggtgmKASK...VSSPKSTSNP....ASSSSSSA
 1709- 1793 (78.98/15.27)	SGRSKSS..........................S............A..SSLTG..........................AMLTGaT.GGTGSGT....GSS..S...............SA.LVNPI....S..................IMKMLGYPT..GSMGNmegfAKS.......................ldTKFQ...IPKLSARSNS....GASGTAST
 1853- 1946 (82.42/16.41)	LGAAAKS..........................S....N.K.MA..PGtSAASV..........................DGTAG.A.GGGGGAG..lhPLL..P..........nivqkMFGSDGSLQTKSN..................SSDGSMFPT..AG.RA....SPG.........................MLSG...SAS.RDGFRS....GGGSGSAP
 1947- 2044 (87.55/18.12)	GTPTTTS..........................SMVLPPFP........SPIS...........................GGASN.D.GDVGSGTlmrpPSR..P...............SSTISNHSHSSQD..................GIGG.GSGN..SGDAV....AGS.................tpavasmaSMMM...MNAMSA.AAG....GGQSPAST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.32|      16|      20|    2089|    2107|      11
---------------------------------------------------------------------------
 2089- 2105 (24.49/ 9.40)	HVVGGAAAlNNLP..SPAS
 2109- 2126 (24.83/ 8.21)	HLVKSPAP.SPLPfaSPHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.04|      24|      25|     642|     665|      12
---------------------------------------------------------------------------
   11-   30 (31.79/ 6.55)	..GGSLPALLMAN.GGGG.....GGSGG
  642-  665 (45.98/13.11)	GAGGAAPGLNNGG.DGTGPA...GGLTG
  667-  694 (33.27/ 7.23)	GDDGTMNGFNLSSlGGPGPAvdgSGAGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.50|      17|      20|     331|     350|      13
---------------------------------------------------------------------------
  334-  350 (28.54/21.40)	QPLLVV....NAGSGSAASVL
  351-  371 (24.96/ 8.46)	QPVYTPiekhNSTSLPATFVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.17|      12|      20|     430|     441|      15
---------------------------------------------------------------------------
  430-  441 (20.88/11.38)	TDLA..KGLLV.SLP
  450-  464 (15.28/ 6.18)	TDNPslRGMMVsSIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.40|      19|      20|     122|     141|      16
---------------------------------------------------------------------------
  122-  141 (29.02/23.57)	LQKtLDSM..QYCIKVT.TRQGL
  142-  163 (22.38/12.14)	VER.LDCLtrQLGLKLSeDTSGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07849 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EPDAVKRSTGAGQPTKRRRSSSSSSSSSSSSSSSSSSSSSTSAASDELEES
2) GAAGVAGATGATNSSSITTTTITSQDVGAAASGATGAGNSSEQRLQTGGATEEDTGGLPLFGETVPAAAGTDAKGSSLGGTTTTNAMISAKNEPPSVLPTGGGDGDTATGATMPLQSSSSSSLSSLSSAGFSLAGGPLAGEPAPDRPCPGTLLLESL
3) GRGPGGMVAREPPEPLAGGAAKKRRMEDFCKSPKSDSN
4) GSLPALLMANGGGGGGSGGPGGGPGGGKGIGKPDIKPPGGGGPSAGGTGTAGKV
5) HEQKFKPNVLGSSTVSLGGAGGGPGGGGGGGGGAGGAAPGLNNGGDGTGPAGGLTGTGDDGTMNGFNLSSLGGPGPAVDGSGAGGGGGSAATNGTAAAQQQRGLMNGEGNGL
6) IAALAAKSGVLPPPPPNNLLNNHHSNHLNNHVVGGAAALN
7) KPALGAVSPIASKVVSPSGGAGLEKTPLPTISGSGLEIIPL
8) KPSSDGIKLTIQNKKGSNKSSSSSSNSGSGSKSSNKSGLKSGVSSGPVSSKQQQQQQQQQQQSNHTTSFSGAFPSSTKSPHYTSSTSSSSKAPFQKSNSFGSLGGSGGTGMKASKVSSPKSTSNPASSSSSSAYSSKEKGGSTSGRSKSSSASSLTGAMLTGATGGTGSGTGSSSSAL
9) NPISIMKMLGYPTGSMGNMEGFAKSLDTKFQIPKLSARSNSGASGTASTGSSESGETGSKSAKDPAARKQKQQTPVTTAAPSVGSSPVRQFSSTSPSGEASARLLSDLLGAAAKSSNKMAPGTSAASVDGTAGAGGGGGAGLHPLLPNIVQKMFGSDGSLQTKSNSSDGSMFPTAGRASPGMLSGSASRDGFRSGGGSGSAPGTPTTTSSMVLPPFPSPISGGASNDGDVGSGTLMRPPSRPSSTISNHSHSSQDGIGGGSGNSGDAVAGSTPAVASMASMMMMNAMSAAAGGGQSPASTGGSLPLDSTSTQQ
10) SVSVHLVKSPAPSPLPFASPHSNASSTHAAGAAGL
11) TSAGTVAASGFPSPSVTSAPIAVPQSNATGSTSSTTATSSSTVKKSSSSSGGGSGSHRKTSDSSERTSSSKSEKKKKRKTDDSAMGPPNKLPYKSSGESSPHRSGGGVGGSSLSTSKSSPKHSSPVHHSSPKHSGSGGPLGFHSPKHGSSVSPKHPLHSGGSSTGGGKPSMSALKSAAASGSSPGSKSSDVGGGGGGTSGASISTAGSSSKERDKERSEKKALQFGTTNTATGSSSLTATSAAGSSSSSSSGGRSKNSSLKLK
978
816
756
12
610
2059
1063
1566
1745
2105
1105
1028
972
793
65
721
2098
1103
1743
2057
2139
1367










Molecular Recognition Features






MoRF SequenceStartStop




1) AAKKRRME
2) GGGKGIGKPDIKPP
3) LKLKQLDL
4) LLSDLL
5) SALKSAA
775
36
1364
1848
1276
782
49
1371
1853
1282