<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07843

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMKIKSDSALFGEGGGLILGASPSIYSSLNPIINQNQVSKREAMLQILQSLKRPSLSSRDYEGMVGEECPSTSQVLYDYSTVDAWMNHPVKRFRPNDESKLSQQMRGMDLYADQKHSEKYLQSLQNTAPDAVNPTRQDQQDPLALPEDADPATGLLSESQIKTEIGCERGDDNGPMLGAHEIKKEKEDKDDLFTEQGLQPGLDDLDQLFDDSANYHDDSDMHVNTSPASTKSGGGCMEDLKRFSGSGHHTMNPGMFSPKELSQMFPTPPSLEHHPNSSPGGGGCMSDGIMIDTMIEPAAAIPVLGSPQEEPIYDWTYVFVPPTISKNVGSTKYAPLPQLPSQLMQPPVPQPPTYKSSSQLRKEKQEREKLIKLREMQEQQEALQQQQAQLENIPPNAGAAGNLIPKQETPLTVPQPLSTPNSLSFNGANHPYSNPPSQGPQPLSRPPSVNSLPGGMIGSGGNLMSPSPIHNGLMNNNLFHPGMGMNVPLRQGMSPISPATPGGATPGSGSMRVPTPQGSCPLPYPSPIGASGGSMPINNIGSPFRRTPILPPPPYDVAVASPATSTTSSYNNKQFGMDDGPATPLAAGNTTPSQRIAIETSALLVNVLLYDTSLNLFRDHNFNSCTLCVCNAGQKCVGNIRGADSGPYLALPGTSFLGSGKGSTPSGSSSEREAAKSTPSSVSQFNGNNHNNNGAFGMVDSPAAGGGNSSGVVAISTSNLQNGYLDEDPIKCTCGFSALVNRRLAHRAGLFYEDELEITGMAEDPAVHKKNSLLQFLLGKINDHNGSSSGINCDISPLPLRIMDLLRQHCAVIQSSSNSIHRAVARFQSAMTAKSLANVTVHILEYTDANDVISLALEQSRLQAINEIKLEDGSALAKSGLLRGVMNVHKWPYLRAGGPKSNQDIVRIMKSMQPLLQDAFHKKSNTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPVPSLVVGYEKDWLSLSPYAIHYWDKLLLEPYSYPRDIAYVVVLPDNDFVVSKVKTYFKELSTTYEMCKLGRHNPIKGWDGILRVGSNRVLKETQNSSMDEWFTSLGDTRLSEMLRLYAQTCQQQLAPYLSKVPSDKSLLDPPENHNASASAHALALAQASSTPNRDGPGQSPMPPPPPSTPDPSQPGDKAPSTPKSDNDQENRDTLNTSSTSPADRMQHDDDGKEPPHIVLYMVEPFTCGTDAPEIERLACLSLLRCYSNILNTVPDSIRSNISVQVISLESIMELGRSRNRLRLSDHMRSQALSIFSQSRRYMQHLNNVKSLTGFGTAANAEQFMKNKDEKNRAPYKLYTPPYVLAKLCEKKESSESFGQTSIKQQCSIMYCNYCLSEDQCWLLAVATDDRGEFLETTTINIDIPNRVRRKRASARRLGLQKLMDFILGLISQTVQPWRIVIGRIGRIGHGELKGWSWLLGKENLRKLSKHLKDICQQCSLLHPVSVPSILSACLVTLEPDSELRVMPDQFTPDERFSQLSMQSPLTTPQDVTCTHILVFPTSARTQSAQSAFVAEHINDELELTLGGNLDDLGLGEDCDEDGINGFDDLFNNWEDIEMPQKMPQDSRQGSPVGSLAQQPMAIGYLVSTAPTGRMPPWFWSSCPHLENVCPVFLRIALHLNSFQILQNNDDPMMQSQSTTEHPLDSNMTADVLRFVLEGYNVLSWLAMDSNTHDRLSCLPMHVQVLMQLYHMMAALA
Length1706
PositionMiddle
OrganismAedes albopictus (Asian tiger mosquito) (Stegomyia albopicta)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Aedini> Aedes> Stegomyia.
Aromaticity0.06
Grand average of hydropathy-0.461
Instability index59.92
Isoelectric point5.70
Molecular weight186903.02
Publications
PubMed=26483478

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07843
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     570.75|     166|     465|     520|     702|       1
---------------------------------------------------------------------------
  164-  227 (44.10/10.73)	....................IGCERGDDNGPML...GAHEI..KKEKEDKDDLFTEQGLQPGLDDLDQlFDDSaNY..HDDSDMH..VNTSPA..............................................................................................................
  273-  359 (86.02/36.05)	....................................................................................H..PNSS...........PGG..GGCMSdgimIDTMIEPAAAIPVLGSPqeePiYDwTYVFVPPTISKNVGSTKYA..PL...PQLPSQLMQPPVPQPPT............YKSSSQL
  372-  492 (168.23/79.68)	LREMQEQQEALQQQQAQLENIPPNAGA.AGNLIPKQETPL..............TVPQPLSTPNSLS..FNGA.NHpySNPPSQGpqPLSRPPsvnsLP.GGMIG.SGGNL..................MSPS...P.IH.NGL..........MNNNLFhpGM..GMNVPLRQG.........................M..
  493-  615 (154.83/97.60)	.....................SPISPATPGG..ATPGS...GSMRVPTPQGS...........................................cpLPyPSPIGaSGGSMP....INNIGSPFRRTPILPPP...P.YD.VAVASPATSTTSSYNNKQF..GMddGPATPLAAGNTTPSQRIAietsallvnvllYDTSLNL
  616-  702 (117.56/48.91)	FRDHNFNSCTLCVCNAGQKCVGNIRGADSGPYLALPGTSFLGSGKGSTPSGSSSEREAAKSTPSSVSQ.FNGN.NH..NNNGAFG..MVDSPA..............................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     205.23|      66|     466|     933|    1008|       2
---------------------------------------------------------------------------
  933- 1008 (102.10/69.98)	TIQgPltWRQFHRLAGR.GTGqcEPQPVpSLVVGYEKdwlsLSPYAIHYWDKL....LLEPYSYPRDI.AYVVVL.PDNDFVV
 1403- 1475 (103.14/46.89)	TVQ.P..WRIVIGRIGRiGHG..ELKGW.SWLLGKEN....LRKLSKHLKDICqqcsLLHPVSVPSILsACLVTLePDSELRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.07|      51|     468|    1158|    1212|       3
---------------------------------------------------------------------------
 1158- 1212 (84.82/50.07)	QENRDTLNTSSTSpadrMQHDDDGKEPPHIVLYMVEPFTC....GTDAPEIERLACLSL
 1636- 1690 (85.25/42.44)	QNNDDPMMQSQST....TEHPLDSNMTADVLRFVLEGYNVlswlAMDSNTHDRLSCLPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.67|      35|     422|     803|     892|       5
---------------------------------------------------------------------------
  858-  892 (60.66/106.95)	QSR..LQAINEIK.LED.GSALAKSGLLRGVMNVHKWPY
 1267- 1305 (48.00/ 8.33)	QSRryMQHLNNVKsLTGfGTAANAEQFMKNKDEKNRAPY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07843 with Med13 domain of Kingdom Metazoa
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