<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07838

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSTAASSLGSMLPANIMANGGGKTSSKAMMELKPTVAGGAAGKGHGKLLPGSGDKHESWQMELLMERLRNKAKSSQYKSFQEMSKAVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTSRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPNGTVQDVKVHHECKMKQQSCSELVSCLQRGDFVDFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLYYLYTLSTQHYTDIHSLLLKSPLGVVQKRRGGHAMKLTYYIAPHDLLDLEAKKEKPLNTELISTEKIGYSVAVNLEASTANKVQIQPLLVQQGNSPVYSPIEKHNSTSLPATFVLRLNKPMALNVAMLKQIKLITGDGSTATNDSSPASNTDLISLIVQHASNGTVNNITRGLFVALPDQYHCYYMTECKNLKGTIISSIPFTEPQHVSKILVFLRQQALFNQLLTSCIRNNGSSSTRVTDYEHLVVFEVAALSCQYITVSLEHPFEESLAMVEFDLSNVLSIQVRVFCNGYESDERLSKRVSAIVQRTMSIPVTLWRLMKIWQEEYEVKFKGQGTGGQGNGTVDEGNFSLSMGPDEGGGNGPAGPGGGGGGTAMNGQMSGNLNGTGMVHQEFCDVKKVKLEPMDPSKKRRTVEDFCKSPKSSKVESEEGDQEMDEEDDDDEYDESTNLSSGDSNSLGENQQTNAGQSSSSTAAMGAPAPVSSVGPRNTISGNGSESSGNSSILGGLDFSSLDPDLMRSSNSSDLDDTAEASEPEIKVKSEEPNYATSVSITPIGVVKSSGSLSNSALNNIGLDKRPGIEIIPLATAGTNIPSSITITPIPMGTSGGSLKSSTGDSGSSDKKLSVSSSGSIHRKSGSSSSSSTSESDRAKLEKKKKRRHEEQLAQLQQMGPPHKILSKSSDGPGSPSGSSRKFSVSPVPLKSGSGSSSSSQIFLSGGSPGSGSKSSPKHSPVHHSSPKHQSSSYGTSSPKHISGGGSGGGKPSMSALKSATSSGSPSSKSSTSGGNPAAGKEECSSGASGTKSSGSGGSSSSRDRDRDRDRERSEKKSGYSSSSSSSSPKLKSPAVKLKQLDLANCGSALSAGVQLELMNSNSSGGSSSGSGSLDLTDSGLFGIGAADLSKNSSAAAASAAGMLLLQQAMKRKGSLSAVIDKLKSAQGGDESSLMLLPELAQQAGFALKESGKSVSSAPSSSAPTSSTSSASVSNHLPGGVSINPASSAAAAALAAHFSSAAAVAAMQAKNSEYMVKPSSDGIKLTIQNKKGSKSGSSGGSSSSSSSSASKSSSKSGTKPPSISGGSMPPKKLPSSQSFSGTYPPTTGSSSSSSGKSLSSGSSSKAPFQKSSSSGSLSSSGNSTMRPSSKSGSSSSSGGGSSSSKDKSRSSSKSSSSSSAAAASLMATNVAMAAAAQAAVNANALNVMKMLGLTSSIQNMEGFVKTLDTKFQIPKLSARSSGGGSSGSGHAGGSDIEKLKQESRPSSSSAPTTPLSNVAQSPTGGNDFSLPFNKLPGDVSPLHSAMLPNVMQKMFPGHDSSMLMRRSPNLDHQSSGNSRDGFSSIYGKGSTTPTTPTGSVPPPFPSPVGMQSHAMDFSNSSDSADASLMRPPSRPSSTMSNHSSSDKLIDATTNSNSMDGLRSTSPAQALAVAAQLINKLDHTQQFVAALKNHHHHLSALSLSNAAAVAAAAASASGGSAGPGPVTSPTSVSVHIMKSPVPSPLPLHGAVAPDEDDTLVGFSGK
Length1746
PositionMiddle
OrganismAedes albopictus (Asian tiger mosquito) (Stegomyia albopicta)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Aedini> Aedes> Stegomyia.
Aromaticity0.04
Grand average of hydropathy-0.433
Instability index56.30
Isoelectric point8.96
Molecular weight180547.98
Publications
PubMed=26483478

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07838
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     542.42|      65|      65|    1275|    1339|       1
---------------------------------------------------------------------------
  858-  916 (56.09/11.09)	SSSGSihrkSGSS........SSS....STSESDRAKLE...KKKK............RRHEEQLAQL...QQ..........M.G..PPH..........KILSKSS..DGPG
  917-  985 (52.40/ 9.81)	SPSGS....SRKF........SVSpvplKSGSGSSSSSQiflSGGSP..G..SGS...KSSPKHSPVH...HS..........SPKHQSSS..........YGTSSPKhiS...
  986- 1031 (55.32/10.82)	..GGG....SGGG........KPS....MSALKSATSSG...SPSSK..SSTSGG...N..............................PA..........AGKEECS..SGAS
 1033- 1095 (44.31/ 7.01)	TKSSG....SGGS........SSS....RDRDRDRDRER...SEKKSgySSSSSS...SSP..KLKS......................PAvklkqldlanCG.SALS..AG..
 1198- 1254 (49.24/ 8.72)	....S....SAPS........SSA....PTSSTS.SASV...SNHLP.....GGV...SINPASSAAA...AA..........LAAHFSSA..........AAVAAMQ..AKNS
 1275- 1339 (114.27/31.20)	SKSGS....SGGS........SSS....SSSSASKSSSK...SGTKP..PSISGG...SMPPKKLPSS...QS..........FSGTYPPT..........TGSSSSS..SGKS
 1341- 1383 (55.90/11.02)	SSGSS....SKAP........FQK....SSSSGSLSSSG...NST..............MRP....SS...K............S.................GSSSSS..GGGS
 1466- 1551 (53.08/10.05)	GSSGS..ghAGGSdieklkqeSRP....SSSSAPTTPLS...NVAQS..P..TGGndfSLPFNKLPGD...VSplhsamlpnvMQKMFPGH..........DSSMLMR..RSPN
 1552- 1613 (61.81/13.06)	LDHQS....SGNS........RDG....FSSIYGK........GSTT..PTTPTG...SVPP.PFPSPvgmQS..........HAMDFSNS..........SDSADAS..LMRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     217.79|      44|      45|     752|     795|       2
---------------------------------------------------------------------------
  618-  658 (35.49/10.66)	TGMVHQEFCDV...K........KVKLEPMDPSKKRRTV.................edfcksPKSSKVE.
  659-  702 (39.31/12.62)	.SEEGDQEMDE...EDDDDEYDESTNLSS.G...DSNSL..................genqqTNAGQSSS
  704-  759 (35.19/10.50)	TAAMGAP.APV...S..........SVGPRNTISGNGSEssgnssilggldfssldpdlmrsSNSSDLDD
  760-  802 (65.16/25.90)	TAEASEPEIKV...KSEEPNYATSVSITPIGVVKSSGSL.......................SNSA.LNN
  803-  852 (42.64/14.33)	IGLDKRPGIEIiplATAGTNIPSSITITPIPMGTSGGSL.................ksstgdSGSSD...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.11|      16|      29|     567|     582|       3
---------------------------------------------------------------------------
  567-  582 (31.22/15.64)	GTGGQGNGTVDEGNFS
  597-  612 (32.89/16.94)	GPGGGGGGTAMNGQMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.13|      26|      29|    1101|    1129|       4
---------------------------------------------------------------------------
 1101- 1121 (28.95/ 7.60)	............MNSNSSGGSSS........GSGSLDLTDS
 1122- 1151 (28.84/14.84)	GLFgigAA...dLSKNSSAAAAS........AAGMLLLQQA
 1156- 1193 (25.34/ 6.19)	GSL...SAvidkLKSAQGGDESSlmllpelaQQAGFALKES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.69|      18|     274|    1407|    1424|       8
---------------------------------------------------------------------------
 1407- 1424 (30.63/23.31)	LMATNVAMAAA.AQAAVNA
 1679- 1697 (22.06/14.31)	LSALSLSNAAAvAAAAASA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07838 with Med1 domain of Kingdom Metazoa
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