<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07838

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSTAASSLGSMLPANIMANGGGKTSSKAMMELKPTVAGGAAGKGHGKLLPGSGDKHESWQMELLMERLRNKAKSSQYKSFQEMSKAVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTSRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPNGTVQDVKVHHECKMKQQSCSELVSCLQRGDFVDFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLYYLYTLSTQHYTDIHSLLLKSPLGVVQKRRGGHAMKLTYYIAPHDLLDLEAKKEKPLNTELISTEKIGYSVAVNLEASTANKVQIQPLLVQQGNSPVYSPIEKHNSTSLPATFVLRLNKPMALNVAMLKQIKLITGDGSTATNDSSPASNTDLISLIVQHASNGTVNNITRGLFVALPDQYHCYYMTECKNLKGTIISSIPFTEPQHVSKILVFLRQQALFNQLLTSCIRNNGSSSTRVTDYEHLVVFEVAALSCQYITVSLEHPFEESLAMVEFDLSNVLSIQVRVFCNGYESDERLSKRVSAIVQRTMSIPVTLWRLMKIWQEEYEVKFKGQGTGGQGNGTVDEGNFSLSMGPDEGGGNGPAGPGGGGGGTAMNGQMSGNLNGTGMVHQEFCDVKKVKLEPMDPSKKRRTVEDFCKSPKSSKVESEEGDQEMDEEDDDDEYDESTNLSSGDSNSLGENQQTNAGQSSSSTAAMGAPAPVSSVGPRNTISGNGSESSGNSSILGGLDFSSLDPDLMRSSNSSDLDDTAEASEPEIKVKSEEPNYATSVSITPIGVVKSSGSLSNSALNNIGLDKRPGIEIIPLATAGTNIPSSITITPIPMGTSGGSLKSSTGDSGSSDKKLSVSSSGSIHRKSGSSSSSSTSESDRAKLEKKKKRRHEEQLAQLQQMGPPHKILSKSSDGPGSPSGSSRKFSVSPVPLKSGSGSSSSSQIFLSGGSPGSGSKSSPKHSPVHHSSPKHQSSSYGTSSPKHISGGGSGGGKPSMSALKSATSSGSPSSKSSTSGGNPAAGKEECSSGASGTKSSGSGGSSSSRDRDRDRDRERSEKKSGYSSSSSSSSPKLKSPAVKLKQLDLANCGSALSAGVQLELMNSNSSGGSSSGSGSLDLTDSGLFGIGAADLSKNSSAAAASAAGMLLLQQAMKRKGSLSAVIDKLKSAQGGDESSLMLLPELAQQAGFALKESGKSVSSAPSSSAPTSSTSSASVSNHLPGGVSINPASSAAAAALAAHFSSAAAVAAMQAKNSEYMVKPSSDGIKLTIQNKKGSKSGSSGGSSSSSSSSASKSSSKSGTKPPSISGGSMPPKKLPSSQSFSGTYPPTTGSSSSSSGKSLSSGSSSKAPFQKSSSSGSLSSSGNSTMRPSSKSGSSSSSGGGSSSSKDKSRSSSKSSSSSSAAAASLMATNVAMAAAAQAAVNANALNVMKMLGLTSSIQNMEGFVKTLDTKFQIPKLSARSSGGGSSGSGHAGGSDIEKLKQESRPSSSSAPTTPLSNVAQSPTGGNDFSLPFNKLPGDVSPLHSAMLPNVMQKMFPGHDSSMLMRRSPNLDHQSSGNSRDGFSSIYGKGSTTPTTPTGSVPPPFPSPVGMQSHAMDFSNSSDSADASLMRPPSRPSSTMSNHSSSDKLIDATTNSNSMDGLRSTSPAQALAVAAQLINKLDHTQQFVAALKNHHHHLSALSLSNAAAVAAAAASASGGSAGPGPVTSPTSVSVHIMKSPVPSPLPLHGAVAPDEDDTLVGFSGK
Length1746
PositionMiddle
OrganismAedes albopictus (Asian tiger mosquito) (Stegomyia albopicta)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Aedini> Aedes> Stegomyia.
Aromaticity0.04
Grand average of hydropathy-0.433
Instability index56.30
Isoelectric point8.96
Molecular weight180547.98
Publications
PubMed=26483478

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364059
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07838
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     542.42|      65|      65|    1275|    1339|       1
---------------------------------------------------------------------------
  858-  916 (56.09/11.09)	SSSGSihrkSGSS........SSS....STSESDRAKLE...KKKK............RRHEEQLAQL...QQ..........M.G..PPH..........KILSKSS..DGPG
  917-  985 (52.40/ 9.81)	SPSGS....SRKF........SVSpvplKSGSGSSSSSQiflSGGSP..G..SGS...KSSPKHSPVH...HS..........SPKHQSSS..........YGTSSPKhiS...
  986- 1031 (55.32/10.82)	..GGG....SGGG........KPS....MSALKSATSSG...SPSSK..SSTSGG...N..............................PA..........AGKEECS..SGAS
 1033- 1095 (44.31/ 7.01)	TKSSG....SGGS........SSS....RDRDRDRDRER...SEKKSgySSSSSS...SSP..KLKS......................PAvklkqldlanCG.SALS..AG..
 1198- 1254 (49.24/ 8.72)	....S....SAPS........SSA....PTSSTS.SASV...SNHLP.....GGV...SINPASSAAA...AA..........LAAHFSSA..........AAVAAMQ..AKNS
 1275- 1339 (114.27/31.20)	SKSGS....SGGS........SSS....SSSSASKSSSK...SGTKP..PSISGG...SMPPKKLPSS...QS..........FSGTYPPT..........TGSSSSS..SGKS
 1341- 1383 (55.90/11.02)	SSGSS....SKAP........FQK....SSSSGSLSSSG...NST..............MRP....SS...K............S.................GSSSSS..GGGS
 1466- 1551 (53.08/10.05)	GSSGS..ghAGGSdieklkqeSRP....SSSSAPTTPLS...NVAQS..P..TGGndfSLPFNKLPGD...VSplhsamlpnvMQKMFPGH..........DSSMLMR..RSPN
 1552- 1613 (61.81/13.06)	LDHQS....SGNS........RDG....FSSIYGK........GSTT..PTTPTG...SVPP.PFPSPvgmQS..........HAMDFSNS..........SDSADAS..LMRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     217.79|      44|      45|     752|     795|       2
---------------------------------------------------------------------------
  618-  658 (35.49/10.66)	TGMVHQEFCDV...K........KVKLEPMDPSKKRRTV.................edfcksPKSSKVE.
  659-  702 (39.31/12.62)	.SEEGDQEMDE...EDDDDEYDESTNLSS.G...DSNSL..................genqqTNAGQSSS
  704-  759 (35.19/10.50)	TAAMGAP.APV...S..........SVGPRNTISGNGSEssgnssilggldfssldpdlmrsSNSSDLDD
  760-  802 (65.16/25.90)	TAEASEPEIKV...KSEEPNYATSVSITPIGVVKSSGSL.......................SNSA.LNN
  803-  852 (42.64/14.33)	IGLDKRPGIEIiplATAGTNIPSSITITPIPMGTSGGSL.................ksstgdSGSSD...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.11|      16|      29|     567|     582|       3
---------------------------------------------------------------------------
  567-  582 (31.22/15.64)	GTGGQGNGTVDEGNFS
  597-  612 (32.89/16.94)	GPGGGGGGTAMNGQMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.13|      26|      29|    1101|    1129|       4
---------------------------------------------------------------------------
 1101- 1121 (28.95/ 7.60)	............MNSNSSGGSSS........GSGSLDLTDS
 1122- 1151 (28.84/14.84)	GLFgigAA...dLSKNSSAAAAS........AAGMLLLQQA
 1156- 1193 (25.34/ 6.19)	GSL...SAvidkLKSAQGGDESSlmllpelaQQAGFALKES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.69|      18|     274|    1407|    1424|       8
---------------------------------------------------------------------------
 1407- 1424 (30.63/23.31)	LMATNVAMAAA.AQAAVNA
 1679- 1697 (22.06/14.31)	LSALSLSNAAAvAAAAASA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07838 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AKNSEYMVKPSSDGIKLTIQNKKGSKSGSSGGSSSSSSSSASKSSSKSGTKPPSISGGSMPPKKLPSSQSFSGTYPPTTGSSSSSSGKSLSSGSSSKAPFQKSSSSGSLSSSGNSTMRPSSKSGSSSSSGGGSSSSKDKSRSSSKSSSSSSAAAA
2) NIPSSITITPIPMGTSGGSLKSSTGDSGSSDKKLSVSSSGSIHRKSGSSSSSSTSESDRAKLEKKKKRRHEEQLAQLQQMGPPHKILSKSSDGPGSPSGSSRKFSVSPVPLKSGSGSSSSSQIFLSGGSPGSGSKSSPKHSPVHHSSPKHQSSSYGTSSPKHISGGGSGGGKPSMSALKSATSSGSPSSKSSTSGGNPAAGKEECSSGASGTKSSGSGGSSSSRDRDRDRDRERSEKKSGYSSSSSSSSPKLKSPAVKL
3) PKLSARSSGGGSSGSGHAGGSDIEKLKQESRPSSSSAPTTPLSNVAQSPTGGNDFSLPFNKLPGDVSPLHSAMLPNVMQKMFPGHDSSMLMRRSPNLDHQSSGNSRDGFSSIYGKGSTTPTTPTGSVPPPFPSPVGMQSHAMDFSNSSDSADASLMRPPSRPSSTMSNHSSSDKLIDATTNSNSMDGLRSTSPAQ
4) QEFCDVKKVKLEPMDPSKKRRTVEDFCKSPKSSKVESEEGDQEMDEEDDDDEYDESTNLSSGDSNSLGENQQTNAGQSSSSTAAMGAPAPVSSVGPRNTISGNGSESSGNSSILGGLDFSSLDPDLMRSSNSSDLDDTAEASEPEIKVKSEEPNY
5) QGTGGQGNGTVDEGNFSLSMGPDEGGGNGPAGPGGGGGGTAMNGQMSGNLNGTGMV
6) SGKSVSSAPSSSAPTSSTSSASVSNHLPGGVS
1251
822
1456
623
566
1193
1405
1080
1650
777
621
1224










Molecular Recognition Features






MoRF SequenceStartStop




1) AVKLKQL
2) EQLAQL
3) KKKKRRH
4) PHKILSK
1077
893
885
904
1083
898
891
910