<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07835

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMETTENTDAIQVSSFPLPPAQYYKLFTDENIRNNRAPKPPAPIQGTYQMFGQQFSTEDNIIRPLEAQGFKRLYPQHFDQKKELKKLNHSLLVNFLDLIDLLVHNPDSPQRAEKIEDLNLLFVHIHHLLNEFRPHQARETLRVMMELQQRQRIETAQRFQNHLEKVREMVNNAFASLPDPIESDRLGSTAEPMDTGDEGEAGKARGEGCHPVDRLMCELVENM
Length222
PositionMiddle
OrganismAedes albopictus (Asian tiger mosquito) (Stegomyia albopicta)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Aedini> Aedes> Stegomyia.
Aromaticity0.07
Grand average of hydropathy-0.715
Instability index43.49
Isoelectric point5.49
Molecular weight25697.78
Publications
PubMed=26483478

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07835
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.02|      19|      22|       5|      26|       1
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    5-   26 (31.76/24.75)	ENtdaIQVSSFPLPPAQ...YYKLF
   29-   50 (33.26/18.29)	EN...IRNNRAPKPPAPiqgTYQMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.17|      20|      24|      94|     117|       2
---------------------------------------------------------------------------
   94-  117 (25.55/27.27)	FLDLIDLLvhNPDSPQRAEkiEDL
  121-  140 (37.62/23.50)	FVHIHHLL..NEFRPHQAR..ETL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07835 with Med7 domain of Kingdom Metazoa
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