<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07832

Description Uncharacterized protein
SequenceMTPQPLEQGGGAVASFIPTGQEMAQRQNLIPLGRLIDFIIQRTYHELTVLAELLPRKTDMERKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMAFLDKQSLLFMDTADMLSRMARETLHPSGVPPDPITTLEKRQTLQRLNQVIQHRLVTGNLLPQLRKFKIENGRVTFKVDHEFEVSLTVMGDGPNIPWRLLDIDVLVEDKETGDGKALVHTLQVNYIHQLIQGRIVDSPDALAEVYNCLHYFCQSLQLEVLYTQTLRLMRDRLDDHIHVDEYIPGTKLTVSYWRELTNKDPKSELGYRLMIQTDQSDTTKQLAILHIPSIGTKEVDIADRAVRSELLSMERLLVHTVYVRSLARLGDLKTELQLFLKDVDYSIQGTPAMLLVPVLNPCLRAEHIYITVDTHTGMLRCHVPKHLDCPIMPELQHALNNDRSKLQHLFSELRYWITQRRCEKTLQHLPATTQERLPLVFPPDHPIEKIGPHRVYIQMCRHANVILIVELKEKDSSPNEMTYTFYLVLVKPSSMEDSQASDQDQPSSTAAASANQSGPGSVPPGGPPSVSSVTAGGTSQTSAPSGSAAAAESDGLPKMYLKVLSLIEFDTFVATHGPGTYVDEQTIGSKRKLLGVEGPSAKQSKTIYPAYFIPELAHVVAMCDEKLPFVALAKDLTRRKIPHGGVQVEANATSLVLKLLTLPQPKPPVIPVASNAAASQSGPDQKPPEPKVVSVPKIDKDVWNALLKRLLSVSVRAQINKSIQTRMWTVELVFYGTPLASMHHKEQGMRRAVYLTYDMLPVDSVDKFVDMILNDWSKIVYLYTLVHDFREQFRNDKYNLHNLVNIKSYSYTSLLLAYGPNKEVNVNIYWDTEAKEFKMVFTGGNNAINAHSMMRDQLQAHLNHNYDLAQIVYLLHETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEVRLRGSGLCSIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDESAVYRRRSQSEDDNPPSPITMEDPHGGPASVGSTFLSGGAMRGPQSPRDPGLRFAAPLTPPSGSNPHTPASPHPQGIGGTQTHPNFNMTSPPAPHMPHPSPSGGLMPSSPLNPQPSPMAAHSPGPTNLPYMSGHTDSPFSAHSPAASNWPGSPGMPRPSPRPGQSPDHKAQTPHHNTSRVLPARSWAGAIPTLLTHEALDTLCRATVHPQKEIPGPELSPLERFLGSVFMRRQLQRIIHQEDNLTAITSNEPGVVLFKADNLQYQVFLNPNHMQSLHMKVSQAPMAPTMDGKPPYQWPPEDLQILEQFFDQRVAAPPYRPAVVTSFTRMLNLPSQVMKDFIQIMRLDLIPELGQGNKWNVQFILRMPPSATPIVPVGTTTILSHRQKILFFIQITRVPYLPNMELKDSVTMLLPMVYDMTVNHTQLAERREQVIPQLTSAVSAHLRRFVECTVLQPGECSLFPAVRDLLMNLTLPNEQPPPGQMGNQIGPMGGMAPGGPGGPGPMGGQIAPSPVGAQVGSSPNPMMHSPMQMGGGGGQQGNYAGMVGGGAQSGGPGGPGAGGPN
Length1571
PositionTail
OrganismAedes albopictus (Asian tiger mosquito) (Stegomyia albopicta)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Aedini> Aedes> Stegomyia.
Aromaticity0.06
Grand average of hydropathy-0.282
Instability index51.08
Isoelectric point8.04
Molecular weight173658.65
Publications
PubMed=26483478

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07832
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     272.33|      40|      40|    1091|    1130|       1
---------------------------------------------------------------------------
  695-  725 (45.78/13.30)	L.TL.P......Q..PKPPVIP.VASN......................AA.ASQSGPDQKPPEP...
 1091- 1127 (70.83/24.45)	.....P.NFNMTS..PPAPHMP.HPSP......................SGGLMPSSPLNPQPSPMAA
 1128- 1170 (60.43/19.82)	H.SPgPtNLPYMSghTDSPFSA.H.SP......................AASNWPGSPGMPRPSPRPG
 1479- 1514 (64.63/21.69)	L.TL.P.N...EQ..PPPGQMGnQIGP......................MGGMAPGGPGGPG..PMGG
 1515- 1570 (30.65/ 6.57)	QiAPsPvGAQVGS..SPNPMM..H.SPmqmgggggqqgnyagmvgggaqSGG..PGGPGAGGP.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     147.92|      34|      40|    1002|    1037|       2
---------------------------------------------------------------------------
  525-  564 (38.33/13.80)	...VKPSSM..EDSQASDqD.........QPSSTAAASAnqsgpgsvPPGGPPS
 1002- 1037 (59.06/30.24)	SKYVDESAVyrRRSQSED.D.........NPPSPITMED........PHGGPAS
 1040- 1078 (50.53/20.49)	STFLSGGAM..RGPQSPR.DpglrfaaplTPPS...GSN........PH.TPAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.04|      19|      40|     294|     312|       3
---------------------------------------------------------------------------
  294-  312 (32.77/26.68)	ELTNKDPKSEL..GYRLMIQT
  335-  355 (26.27/19.55)	DIADRAVRSELlsMERLLVHT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.93|      23|      41|    1371|    1393|       4
---------------------------------------------------------------------------
 1371- 1393 (39.82/19.57)	LRMP..P......SATPIVPVGTTTILSHRQ
 1402- 1432 (28.94/12.20)	TRVPylPnmelkdSVTMLLPMVYDMTVNHTQ
 1435- 1451 (20.17/ 6.26)	ER............REQVIPQLTSAVSAH..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.54|      24|      41|     415|     438|       5
---------------------------------------------------------------------------
  415-  438 (46.01/31.88)	RC.HVPKHLDCPIMPELQHALNNDR
  456-  480 (39.52/26.05)	RCeKTLQHLPATTQERLPLVFPPDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.80|      40|      41|    1235|    1274|       6
---------------------------------------------------------------------------
 1235- 1274 (68.17/43.23)	VFMR....................RQLQRIIHQEDNLTAITSNEPGVV..LFKADNLQYQVF
 1283- 1344 (53.64/32.33)	LHMKvsqapmaptmdgkppyqwppEDLQILEQFFDQRVAAPPYRPAVVtsFTRMLNLPSQVM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.48|      25|      65|     825|     849|       8
---------------------------------------------------------------------------
  825-  849 (42.02/27.87)	REQ...FRNDKYNLHNLVNIKSYSYTSL
  869-  888 (23.50/12.20)	AKE...FKMVFTGGNNAINAHSM.....
  890-  917 (35.96/22.74)	RDQlqaHLNHNYDLAQIVYLLHETYQPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07832 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EDSQASDQDQPSSTAAASANQSGPGSVPPGGPPSVSSVTAGGTSQTSAPSGSAAA
2) MNLTLPNEQPPPGQMGNQIGPMGGMAPGGPGGPGPMGGQIAPSPVGAQVGSSPNPMMHSPMQMGGGGGQQGNYAGMVGGGAQSGGPGGPGAGGPN
3) YRRRSQSEDDNPPSPITMEDPHGGPASVGSTFLSGGAMRGPQSPRDPGLRFAAPLTPPSGSNPHTPASPHPQGIGGTQTHPNFNMTSPPAPHMPHPSPSGGLMPSSPLNPQPSPMAAHSPGPTNLPYMSGHTDSPFSAHSPAASNWPGSPGMPRPSPRPGQSPDHKAQTPHHNTSRVLPARSWA
531
1477
1011
585
1571
1194










Molecular Recognition Features






MoRF SequenceStartStop




NANANA