<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07811

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSSGGPGTGGGGGGGTLPALLMANGGGGKLSSINSSAGGGSKPDVKPTLGGTSGGPGSKVLLGGDKHETWQMELLMERLRTKAKSAQYKSFPEMSKTVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTTRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPLLGTVQDVKVHHECKMKQQSCSELVACLQRGDFADFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLHTLYTLTANRYTEVHSLLLQSPLGVLQKRRGGHPMRLTYFVPPYELLDPATRTMNVLSAELIARERIGCSVTVVLEAASANKLQIQPLLINGAGAGVGTGGGSTPTYAAIEKHNSTSLPATFVLRLSKPIPIDGAMMAAIRTVVGRSEGSADESTTGTGTRNTSLMALIAQHASGGTVQELSRGLPVTLPDQYHCYYLTDNPSLRGVMVSSIPFTEPQHVPKLLVYLRRAAVFNQLLASCIRSTSTTATVTTSVSASGMMSGAGTELPAPVPLVFEVTALSCDYITVSLMHPYEESLATVEFDLQNIASIVVHVYCGEGDGTGGDDGRTAEAAEHISAVLQRCMSIPVTLRALVRYWKEQQEQKFKRNGTIGGAGSTGSTSTAGPGGPDGGGPGGGGGLGSSTPDDSNGFPSLSLGPPSVEGGSNGGANGGAPTGAGSSANGTLNGTGLGALTLHQQHQQMLLQQQQQQQQQQQRPSVGGTMMNGMAANGFGLLASSLGTGMEGFCDILTAATATGARNGGPAGIGDAVGGMQMGGLREPPDALTGAATKKRRLNEDFCKSPKSDSNHTAVGGGTEDTTNSNNSNSSNSNSSTHASGGVATVAAVAAAAAAALLDEVQRGGAGGAIGGTEEDVGRRMAALLGGESGNANGSDSGCSLGEQQQQQQHNRTTEKPQPQSNSNHPLPPPPSASSLASGTAASAGNSAAAAAAALTALLDDTDKNRRMAAGTLLLESLNFPAGPEPPGAGLVDGGRKRKRSSSSSSSSSSSSSSSTSSSSSSSSSDAEEEETVDLVEAEMSSFFAESASTLAVTMATTTALATAMATTTVTTTLTPSINATATTTAAASVGVGSGAKVTTLAASGQGKPTSTTLAMAIGTTGKPPILPTALSAMIGEEKRPVGGAMMAGGLEIIPLGASAGVTNSNMTGAVATSPTVTAASSTATLKKSSSSSGTSSSSSSHRKTADSGDRGKPEKKKKRKADEGLIGVATAATMGPPNKIPLLKSGESSPSHRKASPKHSATSPVHHSSPKHGSGGLGFHSPKHGTGSTGSSPKHLTGGAGGGGSAGGMSGGGGKPSMSALKSAAATAGSSPKSSSSAGGDLSLLGSGSAGGSSNSSKERGGDKEHRAEKKALQFSGTSSSLSVSSGGSGAIGRSKNATLKQLKQLDLSISVDSGSGGGGSPATIDLTGSPTSSGGLTSSLGLGTGSIAAANMLQALQAAKHQRATSKSMSQQQQQQQQQLAQHGGGALSAVIDKLKSAQSADGEDGAVLVLPEMTITQQTQPSSMATGTSVNIGSFGALSGPGAGGSAITLKDVTKAGLLSSSSTSSSSSSASLTNCASLGINSASQSPSMTSASGKASEYMVKPSSDGIKLTIQNKKGSKSSSSSSNSSGSKSGTGGGSGGGSSKTGLKPGVSSGPISSKQQQQQSLQNHTTSFSGAFPSSTKSGHGSPHYTSSSSSSSKTPFQKSNSFGSLSGSSGGGTGGVLKASSKVSSPKSTSNPGNSSSYASSKDKSSSGRLGSSKSSSTLGLSAAGTTGGSTSLVNPISIMKMLGYPTSASSDGFAKTLDTKFQIPKLSARTANAQSGNDGTNEDRAKERGLTVAGTKEASSAASRKQKQQSSSGGGGGGAGGTMRPFAPSPSGSSNDGTNASTTNTNTARLLSDLLGAGAASGLKTTGKATSTAGSNESNVSSLHPLLPNIVQKMFGNESGSTASGGAASAAAAASSSAGSMMSHKSNSSDGSMFPGGSASAGLMASMRSGSAPSTPTTTTAAAAAPSVLPPYQSPVANDSGGVANDLLSALMRPPSRPSMTQSNHSHVAQDGAVDGTGLASMLMMAGSGGSAAAGLVGLDGATNTQQLMAALKSAAAAGSTIGPATNHHNHLQSNHHHTNHHVTSPASVSVHIVKSPAPSPLPFPSPHGGGGGGSVGVIDDDMLDEALIGIGSK
Length2185
PositionMiddle
OrganismAnopheles albimanus (New world malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.304
Instability index50.03
Isoelectric point9.15
Molecular weight217445.59
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07811
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|    1433.17|     187|     189|    1530|    1716|       1
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  611-  762 (138.28/26.13)	.........RNGTIGGA..GS...TGS.....TSTAG.PG.....GP..........................................DG.GG.......P..GGGGGLGSSTP.DD..SNGFPS.....L....S................lgPP....SVE...GGSNGGA.NG.......gaP.tGA..G...S........SangtlngtglgALTLHQQHQQMLLQ.QQQQQQ...Q............................................................QQQR...PSVG..........G.TM..MNGM..AA......NgFGL..............LA.............SSLGTGMEgFC....DI.LTAATA.......TGAR
  763-  883 (109.96/18.95)	N..GG....PAGIGDAV..GGmqmGGL.....RE..P.PDA..LTGAAT.KKRrlnedfcKSPKSDSNHTA........................................................................................................................vgG...G........T...............EDTTN.......SNNSN...SSNSN.......SSTH.AS.....GG..................................V..AT...VAAV..........A.AA..AAAA..LL......D.EVQ..............RG.............GAGGAIGG.TE....ED.VGRRMA.......A...
  884- 1091 (159.39/31.47)	.LLGG....ESGNANGS..DS..................GC..SLG....EQQ.......QQQQ..HNRTT..EKPQPQ.......S.NSNHPL.......PPPPSASSLASGTAASA..GNSAAA.....A....AaaltallddtdknrrmaaGTllleSLN...FPA.GP..EP.........P..GA..GlvdG........G...........R......KRKRSSS.SSSSSS...SSSSS.......STSSSSS..........................................SSSS...DAEEeetvdlveaeM.SSffAES...AS......T.LAVtmatttalatamatTT.............VTTTLTPS.IN....AT.ATTTAA.......ASVG
 1092- 1294 (161.66/32.05)	VGSGA....KVTTLAAS..GQ...GK....................PTS.....................TTLAMAIGT.......TGKP.PIL.......PTALSAMIGEEKRPVGG..AMMAGG.....L....E..........iiplgasaGV....T.N...SNMTGAVaTS.........PtvTA..A...S........S...........TATLKKSS.....S.SSGTSS...SSSSH.......RKT..AD.....SGdrgkpekkkkrkadegligvataatmgppnkiplLKSGE...SSPS..........H.RK..ASPK..HSatspvhH.SSP..............KH.............GSGGLGFH..S....PK.HGTGST.......GSSP
 1295- 1438 (143.17/27.36)	KHLTG....GAG.GGGS..AG...GMS.....GGGGK.P................................SMS.ALKS.......AAATAGSS.......PK..SSSSAG.............GD.....LsllgS..................G.............SAGGS.SN.........S..SKerG...GdkehraekK...........ALQF.....SGTSS.SLSVSS...GGSGAigrsknaTLKQLKQ.....LD..................................L........SIS..........V.DS..GSGG..GG........................................SPATIDLT...........GSPTS.......SGGL
 1439- 1629 (229.74/49.28)	TSS.......LGLGTGS..IA...AANmlqalQAAKH.QRA..TSKSMSqQQQ.......QQQQQLAQH....GGGALSavidklkSAQSADGEdgavlvlPEM.........TITQQ..TQPSSM.....A....T..................GT....SVN...IGSFGAL.SG.........P..GA..G...G........S...........AITLKDVTKAGLLS.SSSTSS...SSSSA.......SLTNCAS.....LG..................................INSAS...QSPS..........M.TS..ASGK..AS......E.YMV..............KP.............SSDGIKLT.IQ....NK.KGSKSS.......SSSS
 1630- 1822 (236.44/50.98)	NSSGS....KSGTGGGS..GG...GSS.....KTGLK.PGV..SSGPIS.SKQ.......QQQQSLQNHTTSFSGAFPS.......STKSGHGS.......PHYTSSSSSSSKTPFQK..SNSFGS.....L....S..................GS..................SG.........G..GT..G...G......................VLKASSKVS..S.PKSTSNpgnSSSYA.......SSKDKSS.....SG.................................rLGSSK...SSST..........LgLS..AAGTtgGS......T.SLV..............NPisimkmlgyptsaSSDGFAKT.LD....TKfQIPKLS.......ARTA
 1823- 1966 (117.69/20.91)	N...A....QSGNDGTN..ED...RAK.....ERGLTvAGTkeASSAAS.RKQ.......KQQSS..............................................................................................................SG.........G..GG..G...G........A...........GGTMRPFAPSP..S.GSSNDG...TNAST.......TNTNTARllsdlLG..................................AGAASglkTTGK..........A.TS..TAG...SN......E.SNV..............SS.............LHPLLPNI.VQkmfgNE.SGSTASggaasaaAAAS
 1967- 2155 (136.83/25.76)	SSAGSmmshKSNSSDGSmfPG...GSA.....SAGLM.ASM..RSGSAP.S...............TPTTTTAAAAAPS.......VL.........................PPYQSpvANDSGGvandlL....S........almrppsrpsMT....QSNhshVAQDGAV.DGtglasmlmmA..GS..G...G........S...........A.......AAGLVGlDGATNT...QQLMA.......ALKSAAA.....AG................................stIGPAT...NHHN.........hL.QS..NHHH..TN......H.HVT..............SP.............ASVSVHI.........V.KSPAPS.......PLPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.63|      25|      26|      10|      34|       2
---------------------------------------------------------------------------
    1-   19 (32.33/ 8.27)	...MSSSG..G...PGTG..GGGGGGTLP
   20-   44 (42.66/13.67)	ALLMANGG..GGKLSSIN..SSAGGGSKP
   45-   72 (31.65/ 7.92)	DVKPTLGGtsGGPGSKV.llGGDKHETWQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.90|      21|      26|     217|     238|       3
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  217-  235 (22.32/13.12)	.......LASIYQLNAEKKIKVNAFV
  237-  262 (26.20/18.95)	LQaletdLHTLYTLTANRYTEVHSLL
  263-  285 (28.37/15.19)	LQ...spLGVLQKRRGGHPMRLTYFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.94|      21|      26|      73|      98|       4
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   73-   98 (25.97/32.50)	MELLMERLrtkAKSAQYKSfpEMSKT
  101-  121 (34.97/22.78)	MSLLEKRY...ALDAVEKS..NLQKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.75|      20|      26|     429|     454|       5
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  404-  436 (24.95/26.00)	TRNTSLMALIAQhasggtvqelsrgLPVTLPDQ
  443-  463 (32.80/14.48)	TDNPSLRGVMVS............sIPFTEPQH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07811 with Med1 domain of Kingdom Metazoa
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