<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07806

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSVHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDMWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFLKDLIPKLHEHYHQGPLQEKPSSGIGSTGGVSLNNSGGASALGMNSASGGSNPTTIPPPLSSPAGSMHSPAGSNSGTGGAMHSQQQQQQQLQQPLSPQEEQRLAQKQWNYSTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLHDFVQSERFCRRLAYAVSKKLAQLINQMADNHNVNLNVSEPDNAGGAKVSADVSETKDGKNDKLSNGGTVTVKPNPYELIFTEYLQCSHHRDVVLQLSCILQTITLECPTALVWCGVGETRSSSVLSGSPLDHLPVAPSALPMPERYAGNSNEDIRRQLFEAEESIKIRSRHAESRWCIDKWQTAAGNASLKILATLDALDGHCFDRMDSNNSLDSLYQKIFPPFQIQPIKPATDSGVLPSNSSSLAGVAGVGAGANSIDGKDAATKQFEYNVEQDASIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVFTALENESYSNNNLNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLEDNGGTQCKSQFTNLVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDNHGICNAGLGTGPISNKPATSSSPNNPSGMDDDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHAATSVGAGLGKAESPSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHARSEFNFEATSNKCQAMSYFDQHVVTWQCAVQVQEMLNSFAAGNSYYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVEMQLIAKGSMPLVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKSRPQQEPFHNAYPKIKQALYTPLQPTPSVHAYNPQFMIDIITNPRRGGKIENGWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSSEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATANKVSSIFGTGKRSGLNTPVHPGSTPKSMSGSGDISHILGTSDLSILGNADESMLDVSQQNSHLNQDNATSLSEFAQHVLRQICSQEWVLERCLQNAEELCQQGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELDQKAIIVRILEILEQWSLRISWLDLQLMFKQTNCSSPELSNWLDMVARAAIDVFRVNEFYVSGPDAKQEKVKPSTWLVAPLVSKLPSAVQGRILKVSGQVLESTSMFSKHKEGNGGNSSSNNNSHSHGANSNSSVSSNGSTFASKQSSQLNHQPFLGLVLTCLKGQDEQKEGLLQSLYAQLSQFLQNRDQSLETVGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVIACESAGSSTDAKGNKINIDSIEKKHGLRLADKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEVDPLPDKLKDEMKADTPSSDQSPAPSTSSKKGKTMGGSMNPMNQQHLQQQYGQQNAGQMVGQGNIGVNRYDRPPLNNPKQALSNMLRSKIPMNAGHPGFMQQQQQQQQQQAQAQRNPQQAFIRGPMRAGIPGNPVVGNPGGMGPMNPAMAGGGAGLGTAAGGVVGGSGGGGGGAGGAGGNVAGGVMGGGQQGGMGAAGMMGVQQGGQGPPGAAGMMNQNSAGLMGSSGASIMGQSGGSMIQANMLNQQNPALVVGQGMGSGGGGAGSAGAGASGAGGGSGIGAGSGMVTGNAGMGGNAGGMGSNAGGMGGNVGGMGTSGGMVTSGGMVTGGMGNSGIGTATAMGGGQGAMGNSGMANNAGMGNPGMANPGMGMGNMQQQGGNMQGGMFQGQNVPYQNVNQNYPNYGNQGMGQQGGQGGMMGNFNPMAQQQRNTQAEFLAQQRALAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNIPQTQQQFQQQQRLRLMMQQQQQQQQSGMGQGGNAQGLIQNQGQGMNTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
Length2482
PositionKinase
OrganismAnopheles albimanus (New world malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.06
Grand average of hydropathy-0.414
Instability index44.20
Isoelectric point6.55
Molecular weight267611.19
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07806
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.91|      15|      15|    2226|    2240|       1
---------------------------------------------------------------------------
 2105- 2120 (24.77/ 7.04)	GGQQGGMGAAGMMgVQ
 2226- 2240 (31.15/11.00)	GGNVGGMGTSGGM.VT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     400.34|      38|      38|    2261|    2298|       2
---------------------------------------------------------------------------
 1953- 1989 (34.79/ 8.40)	..........G..GSMNP..M..NQ...Q.H..LQQQ................YG..Q..Q................NAG......qmVGQG....NIGVNRYDR
 1990- 2028 (39.26/10.46)	PPL.......N..NPKQA..L..SNmlrS.K..IPMN................A......G................HPG........FMQQ....QQQQQQQQA
 2029- 2062 (43.24/12.31)	QAQ.......R..NPQQA..F..IR...G.P..M..R................AG..I.pG................NPV........VGNP....G.GMGPM..
 2077- 2135 (39.27/10.47)	AGG..vvggsG..GGGGG..A..GG...A.G...GNV................AGgvM..GggqqggmgaagmmgvqQGG........QGPP....G.AAGMMNQ
 2136- 2177 (30.33/ 6.33)	NSA.......GlmGSSGAsiM..GQ...S.GgsMI.Q................AN..M..L................N..........QQNPalvvGQGMGS...
 2178- 2219 (33.00/ 7.56)	.GGggagsagA..GASGA..G..GG...S.G..IGAG................SG..MvtG................NAG........MGGN....AGGMG....
 2262- 2295 (68.96/24.22)	.............GGQGA..M..GN...S.G..MANN................AG..M..G................NPG........MANP....GMGMGNMQQ
 2296- 2329 (39.23/10.45)	QGG....nmqG..G......MfqGQ...N.V..PYQN................VN..Q..N................YPN........YGNQ....GM..G...Q
 2330- 2380 (34.61/ 8.31)	QGG......qG.....GM..M..GN..fN.P..MAQQqrntqaeflaqqralaAG..R..G................QYG........QHAP....NVTMGNM..
 2423- 2474 (37.66/ 9.73)	QQQ...qqqsG..MGQG......GN...AqG..LIQN................QG..Q..G...........mntqqTPNlvaqlqrqMPNQ....NNMMG..QQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.55|      16|      16|     744|     759|       3
---------------------------------------------------------------------------
  743-  758 (29.36/17.71)	YMCCLISRGDLLTGAG
  759-  774 (28.19/16.67)	GMLSLDNHGICNAGLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.84|      12|      16|    2381|    2393|       6
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 2381- 2393 (19.75/16.57)	GVNqGAVPPYPRQ
 2398- 2409 (23.09/13.64)	GVG.GNIPQTQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     431.65|     171|     301|    1223|    1511|       7
---------------------------------------------------------------------------
 1223- 1306 (75.96/249.45)	YVDVltQVDVQNTNIHN.ALSVFTSiLVAR...HCFSLENFvaHVALPSLVQAcKGRGETT.........PEIEAG..ARLSCHLL..LRLFKTIECPQPG......................................................................................................................................................................
 1358- 1470 (90.65/115.99)	.....................................................................................................lysvstspnpitvgnahniklscdrhllaaahknigvapvlavlkgilvvgDATANKVSSIFGTGKRSGLNTpvhPGSTPKSmSGSGDISH..ILGTSdLSILGNADEsmldvsqQNSHLNQDNATSLSEFAQhvlrqicSQEWVLErCLQNAEELCQQGMLIDNL
 1518- 1707 (265.05/ 0.00)	WLDL..QLMFKQTNCSSpELSNWLD.MVARaaiDVFRVNEF..YVSGPDAKQE.KVKPSTWlvaplvsklPSAVQGriLKVSGQVLesTSMFSKHKEGNGG...................................................NSSSNNNSHSHGANSNSSVSS...NGSTFAS.KQSSQLNHqpFLGLV.LTCLKGQDE.......QKEGLLQSLYAQLSQFLQ.......NRDQSLE.TVGGIEDPCGFEKMLDAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.45|      28|     300|     549|     577|       8
---------------------------------------------------------------------------
  549-  577 (50.57/39.77)	GHCFDRMDSNnSLDSLYQKIFPPFQIQPI
  851-  878 (53.88/37.19)	GAGLGKAESP.SRHFLYTEHFPLCQDDPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.28|      23|     301|     413|     436|       9
---------------------------------------------------------------------------
  413-  436 (40.84/30.89)	NGGTvTVKPNPYELI..FTEYLQ...CSH
  713-  740 (33.45/19.80)	NGGT.QCKSQFTNLVhlFSELIRhdvFSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     276.27|      85|     342|     241|     333|      10
---------------------------------------------------------------------------
  242-  333 (140.09/99.24)	PPPLSSPAGSMHSPAGSNSgTGGAMHSQQQQQQQLQQPLSPQE...EQRLAQKQWNYStqlcKYMYEEGLLDKQEflNWIIDLLEKMKSS....PNADD
  587-  678 (136.18/77.55)	PSNSSSLAGVAGVGAGANS.IDGKDAATKQFEYNVEQDASIVKilcEWAVSWQRWGEH....RAMVVAWLLDKRQ..NEVFTALENESYSnnnlNNSDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.20|      10|      17|    1103|    1112|      11
---------------------------------------------------------------------------
 1103- 1112 (21.50/11.18)	P.QQEPFHNAY
 1122- 1132 (16.70/ 6.91)	PlQPTPSVHAY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07806 with Med12 domain of Kingdom Metazoa
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