<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07806

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSVHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDMWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFLKDLIPKLHEHYHQGPLQEKPSSGIGSTGGVSLNNSGGASALGMNSASGGSNPTTIPPPLSSPAGSMHSPAGSNSGTGGAMHSQQQQQQQLQQPLSPQEEQRLAQKQWNYSTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLHDFVQSERFCRRLAYAVSKKLAQLINQMADNHNVNLNVSEPDNAGGAKVSADVSETKDGKNDKLSNGGTVTVKPNPYELIFTEYLQCSHHRDVVLQLSCILQTITLECPTALVWCGVGETRSSSVLSGSPLDHLPVAPSALPMPERYAGNSNEDIRRQLFEAEESIKIRSRHAESRWCIDKWQTAAGNASLKILATLDALDGHCFDRMDSNNSLDSLYQKIFPPFQIQPIKPATDSGVLPSNSSSLAGVAGVGAGANSIDGKDAATKQFEYNVEQDASIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVFTALENESYSNNNLNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLEDNGGTQCKSQFTNLVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDNHGICNAGLGTGPISNKPATSSSPNNPSGMDDDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHAATSVGAGLGKAESPSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHARSEFNFEATSNKCQAMSYFDQHVVTWQCAVQVQEMLNSFAAGNSYYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVEMQLIAKGSMPLVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKSRPQQEPFHNAYPKIKQALYTPLQPTPSVHAYNPQFMIDIITNPRRGGKIENGWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSSEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATANKVSSIFGTGKRSGLNTPVHPGSTPKSMSGSGDISHILGTSDLSILGNADESMLDVSQQNSHLNQDNATSLSEFAQHVLRQICSQEWVLERCLQNAEELCQQGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELDQKAIIVRILEILEQWSLRISWLDLQLMFKQTNCSSPELSNWLDMVARAAIDVFRVNEFYVSGPDAKQEKVKPSTWLVAPLVSKLPSAVQGRILKVSGQVLESTSMFSKHKEGNGGNSSSNNNSHSHGANSNSSVSSNGSTFASKQSSQLNHQPFLGLVLTCLKGQDEQKEGLLQSLYAQLSQFLQNRDQSLETVGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVIACESAGSSTDAKGNKINIDSIEKKHGLRLADKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEVDPLPDKLKDEMKADTPSSDQSPAPSTSSKKGKTMGGSMNPMNQQHLQQQYGQQNAGQMVGQGNIGVNRYDRPPLNNPKQALSNMLRSKIPMNAGHPGFMQQQQQQQQQQAQAQRNPQQAFIRGPMRAGIPGNPVVGNPGGMGPMNPAMAGGGAGLGTAAGGVVGGSGGGGGGAGGAGGNVAGGVMGGGQQGGMGAAGMMGVQQGGQGPPGAAGMMNQNSAGLMGSSGASIMGQSGGSMIQANMLNQQNPALVVGQGMGSGGGGAGSAGAGASGAGGGSGIGAGSGMVTGNAGMGGNAGGMGSNAGGMGGNVGGMGTSGGMVTSGGMVTGGMGNSGIGTATAMGGGQGAMGNSGMANNAGMGNPGMANPGMGMGNMQQQGGNMQGGMFQGQNVPYQNVNQNYPNYGNQGMGQQGGQGGMMGNFNPMAQQQRNTQAEFLAQQRALAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNIPQTQQQFQQQQRLRLMMQQQQQQQQSGMGQGGNAQGLIQNQGQGMNTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
Length2482
PositionKinase
OrganismAnopheles albimanus (New world malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.06
Grand average of hydropathy-0.414
Instability index44.20
Isoelectric point6.55
Molecular weight267611.19
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07806
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.91|      15|      15|    2226|    2240|       1
---------------------------------------------------------------------------
 2105- 2120 (24.77/ 7.04)	GGQQGGMGAAGMMgVQ
 2226- 2240 (31.15/11.00)	GGNVGGMGTSGGM.VT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     400.34|      38|      38|    2261|    2298|       2
---------------------------------------------------------------------------
 1953- 1989 (34.79/ 8.40)	..........G..GSMNP..M..NQ...Q.H..LQQQ................YG..Q..Q................NAG......qmVGQG....NIGVNRYDR
 1990- 2028 (39.26/10.46)	PPL.......N..NPKQA..L..SNmlrS.K..IPMN................A......G................HPG........FMQQ....QQQQQQQQA
 2029- 2062 (43.24/12.31)	QAQ.......R..NPQQA..F..IR...G.P..M..R................AG..I.pG................NPV........VGNP....G.GMGPM..
 2077- 2135 (39.27/10.47)	AGG..vvggsG..GGGGG..A..GG...A.G...GNV................AGgvM..GggqqggmgaagmmgvqQGG........QGPP....G.AAGMMNQ
 2136- 2177 (30.33/ 6.33)	NSA.......GlmGSSGAsiM..GQ...S.GgsMI.Q................AN..M..L................N..........QQNPalvvGQGMGS...
 2178- 2219 (33.00/ 7.56)	.GGggagsagA..GASGA..G..GG...S.G..IGAG................SG..MvtG................NAG........MGGN....AGGMG....
 2262- 2295 (68.96/24.22)	.............GGQGA..M..GN...S.G..MANN................AG..M..G................NPG........MANP....GMGMGNMQQ
 2296- 2329 (39.23/10.45)	QGG....nmqG..G......MfqGQ...N.V..PYQN................VN..Q..N................YPN........YGNQ....GM..G...Q
 2330- 2380 (34.61/ 8.31)	QGG......qG.....GM..M..GN..fN.P..MAQQqrntqaeflaqqralaAG..R..G................QYG........QHAP....NVTMGNM..
 2423- 2474 (37.66/ 9.73)	QQQ...qqqsG..MGQG......GN...AqG..LIQN................QG..Q..G...........mntqqTPNlvaqlqrqMPNQ....NNMMG..QQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.55|      16|      16|     744|     759|       3
---------------------------------------------------------------------------
  743-  758 (29.36/17.71)	YMCCLISRGDLLTGAG
  759-  774 (28.19/16.67)	GMLSLDNHGICNAGLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.84|      12|      16|    2381|    2393|       6
---------------------------------------------------------------------------
 2381- 2393 (19.75/16.57)	GVNqGAVPPYPRQ
 2398- 2409 (23.09/13.64)	GVG.GNIPQTQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     431.65|     171|     301|    1223|    1511|       7
---------------------------------------------------------------------------
 1223- 1306 (75.96/249.45)	YVDVltQVDVQNTNIHN.ALSVFTSiLVAR...HCFSLENFvaHVALPSLVQAcKGRGETT.........PEIEAG..ARLSCHLL..LRLFKTIECPQPG......................................................................................................................................................................
 1358- 1470 (90.65/115.99)	.....................................................................................................lysvstspnpitvgnahniklscdrhllaaahknigvapvlavlkgilvvgDATANKVSSIFGTGKRSGLNTpvhPGSTPKSmSGSGDISH..ILGTSdLSILGNADEsmldvsqQNSHLNQDNATSLSEFAQhvlrqicSQEWVLErCLQNAEELCQQGMLIDNL
 1518- 1707 (265.05/ 0.00)	WLDL..QLMFKQTNCSSpELSNWLD.MVARaaiDVFRVNEF..YVSGPDAKQE.KVKPSTWlvaplvsklPSAVQGriLKVSGQVLesTSMFSKHKEGNGG...................................................NSSSNNNSHSHGANSNSSVSS...NGSTFAS.KQSSQLNHqpFLGLV.LTCLKGQDE.......QKEGLLQSLYAQLSQFLQ.......NRDQSLE.TVGGIEDPCGFEKMLDAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.45|      28|     300|     549|     577|       8
---------------------------------------------------------------------------
  549-  577 (50.57/39.77)	GHCFDRMDSNnSLDSLYQKIFPPFQIQPI
  851-  878 (53.88/37.19)	GAGLGKAESP.SRHFLYTEHFPLCQDDPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.28|      23|     301|     413|     436|       9
---------------------------------------------------------------------------
  413-  436 (40.84/30.89)	NGGTvTVKPNPYELI..FTEYLQ...CSH
  713-  740 (33.45/19.80)	NGGT.QCKSQFTNLVhlFSELIRhdvFSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     276.27|      85|     342|     241|     333|      10
---------------------------------------------------------------------------
  242-  333 (140.09/99.24)	PPPLSSPAGSMHSPAGSNSgTGGAMHSQQQQQQQLQQPLSPQE...EQRLAQKQWNYStqlcKYMYEEGLLDKQEflNWIIDLLEKMKSS....PNADD
  587-  678 (136.18/77.55)	PSNSSSLAGVAGVGAGANS.IDGKDAATKQFEYNVEQDASIVKilcEWAVSWQRWGEH....RAMVVAWLLDKRQ..NEVFTALENESYSnnnlNNSDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.20|      10|      17|    1103|    1112|      11
---------------------------------------------------------------------------
 1103- 1112 (21.50/11.18)	P.QQEPFHNAY
 1122- 1132 (16.70/ 6.91)	PlQPTPSVHAY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07806 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAGGVVGGSGGGGGGAGGAGGNVAGGVMGG
2) DLDKLLQHIKEDQQNSMDAPDSPKDPEHAATSVGAGL
3) GLGTGPISNKPATSSSPNNPSGMDDDVLQTDF
4) GNSGMANNAGMGNPGMANPGMGMGNMQQQGGNMQGGMFQGQNVPYQNVNQNYPNYGNQGMGQQGGQGGMMGNFNPMAQQQRNTQAEFLAQQRALAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNIPQTQQQFQQQQRLRLMMQQQQQQQQSGMGQGGNAQGLIQNQGQGMNTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
5) HEHYHQGPLQEKPSSGIGSTGGVSLNNSGGASALGMNSASGGSNPTTIPPPLSSPAGSMHSPAGSNSGTGGAMHSQQQQQQQLQQPLSPQEEQRL
6) LPLPPEEVDPLPDKLKDEMKADTPSSDQSPAPSTSSKKGKTMGGSMNPMNQQHLQQQYGQQNAGQMVGQGNIGVNRYDRPPLNNPKQALSNMLRSKIPMNAGHPGFMQQQQQQQQQQAQAQRNPQQAFIRGPMRAGIPGNPVVGNPGGMGPMNPAMAGGGA
7) MFSKHKEGNGGNSSSNNNSHSHGANSNSSVSSN
8) MNMRPLKRPRLGPPDVYPQEAKQREDELTSVHVKH
2076
818
772
2268
194
1911
1602
1
2105
854
803
2482
288
2071
1634
35










Molecular Recognition Features






MoRF SequenceStartStop




1) MNMRPLKRPRLG
1
12