<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07800

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTPQPLEQGGAVANFIPTGQEMAQRQNLIPLRQLIDFIIQRTYHELTVLAELLPRKTDMDRKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMGFLDKQSMLFIDTADMLSRVARETLVHARLPNFHIPAAVEILTTGTYSRLPSIIRERIVPPDPITPAEKRQTLQRLNQVIQHRLVTGNLLPQLRKFRIENGRVTFKVDHEFEVSLTVMGDAPTVPWRLLDIDFLVEDKETGDGKALVHPLQVNYIHQLIQGRIVDCTDALAEVYTCLHYFCQSLQLEVLYTQTLRLIRDRLDDHIHVDEYIVGSKLTVSYWRELTNKDPKSELGYRLTIQTDPNDCAKQLAILHVPSIGNKEADIADRAVRSDLLSMERLLVHTVYVRSLARLNDVKTELQLFLKDVEYNIHGTPAMLTVPVLNPCLRAEHIYITVDTHTGMLRCHVPKHLDCPIMPDMQHALNNDWSKLQHLISELRYWITQRRCEKTLQHLPASTQDRLPILYPPNHPISRMGPHKVFIQLYRHANVILIVELKEKKSCPNEMTYTFYIALVKPSSVEEGQTGGPEVPSNAGPSAAGGPGGAEAAAGMPKMYLRVLSLIEFDTFVATHGPGTYIDEPLAGCNKRKQLATELTTGVVGPPVKQQKTIYPAYFIPELAHVVAMCDEKLPFVALAKEFSNRRIPHGGLQVEANATSLVLKLLTLPQPKPPQIVPTNAQQQQQQQQQQQQQQQQQQQQQQQQSHPQQGAAGADGKATNEPKTVHVPPIDKQVWNALLKRLLSVSVRAQVNKSNQTRPWTMELVFYGSPLPSQHHKEQGMRRAVYLQYEMLPVDSVGKVVDQLLNDWSKIVYLYTLVHEFQEQLANEKYNLASMVTIKSYSYTNLLLAYGPNKDVSVNICWDTEAKEFKLVFTGGNSAINAHSMMRDQLQAHLNHNYNLAQIVHILYETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEVRFRGGGLCTVRDGAYSRFDRTHVVEEFTPTQGLKGFLSKYVDESVFRRRSQSEDDNPPSPVTMEDPSHMVGSVGGGAGGGGGAGGGGGTGANNLFGGGAGGGMRGPQSPRDPGLRFAAPLTPPTGSNPHTPASPHPQVGGSGGAGGAGGGGGAGGQGGAGGQGNHMNNFNMTSPPASHMPHPSPSGGLMPSSPLNAQPSPMAAHSPGPSNLAYMQSHTDGSPFAALSPAASNWPGSPGMPRPSPRPGQSPEHKVQTPHHYTSRVIPARSWAGAIPTLLTYEALDTLCRATSHPQKEIPGPELSPLERFLGSVFMRRQLQRIIHQEDSLMAIQSNEPGVVVFKADCLQYQVFLNPNHMQSLHLKANQLQMGGNTMMDGKPVYQWANEDLQVLEQFFDQRVAAPPYRPSVMTSFTRMLNLPAKVLMDFIQIMRLDLMPELGQGNKWNVQFVLRMPPSATPIVPVGTTTILSHRQKILFFIQITRVPYLPNMEWKDAVTMLLPMVYDMNMNHTTLAERREPMPPQLTSAVSAHLRRFSECSVLQQGECSLFPAVRDLLLTLTLPNEPPAPGQMPLQLGGVMQQGGPGGPGGPGGPMGGQNAGQVVVGPVGSSPNPMIHSPMQQQQMVGGGGGGQPQGSYGGMVGGGGPQSGGGPN
Length1648
PositionTail
OrganismAnopheles albimanus (New world malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy-0.303
Instability index52.88
Isoelectric point8.52
Molecular weight181291.85
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07800
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     235.00|      34|      67|    1053|    1086|       1
---------------------------------------------------------------------------
 1053- 1086 (67.56/27.08)	PPS...PVTMEDPSHMVGSVG....GGAGGGGGAGGG.GG..TG
 1118- 1156 (60.47/23.41)	PPTgsnPHTPASPHPQVGGSG..gaGGAGGGGGAGGQ.GG..AG
 1560- 1595 (57.02/21.63)	PPA...PGQMPLQLGGVMQ.Q....GGPGGPGGPGGPmGGqnAG
 1598- 1633 (49.96/17.99)	VVG...PVG.SSPNPMI.HSPmqqqQMVGGGGGGQPQ.GS..YG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.84|      14|      21|    1193|    1206|       2
---------------------------------------------------------------------------
 1193- 1206 (30.66/15.55)	QPSPMAAHSPGPSN
 1215- 1228 (25.18/11.15)	DGSPFAALSPAASN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.19|      14|      25|     145|     158|       3
---------------------------------------------------------------------------
  112-  125 (21.38/13.95)	TADMLSRVARETLV
  145-  158 (23.57/16.25)	TYSRLPSIIRERIV
  171-  184 (23.25/15.91)	TLQRLNQVIQHRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.05|      15|      21|     706|     726|       4
---------------------------------------------------------------------------
  712-  726 (28.56/23.92)	PTNAQQQQQQQQQQQ
  730-  744 (29.49/10.15)	QQQQQQQQQQSHPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.66|      16|      19|     941|     959|       5
---------------------------------------------------------------------------
  941-  959 (24.52/20.52)	ILYETYQPLSSiakLPIIP
  963-  978 (30.14/17.01)	ILQSPKIPVLS...FCIIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.75|      23|      72|    1088|    1116|       6
---------------------------------------------------------------------------
  564-  586 (41.89/11.13)	GGPEVPSNAGPSAAGGPGGAEAA
 1092- 1114 (47.86/28.53)	GGGAGGGMRGPQSPRDPGLRFAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.79|      24|      48|    1422|    1449|       8
---------------------------------------------------------------------------
 1422- 1449 (39.57/28.26)	FIQIMRLDLMPELgqgnKWNVQFVLRMP
 1473- 1496 (45.22/22.91)	FIQITRVPYLPNM....EWKDAVTMLLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.37|      37|     557|     288|     373|      11
---------------------------------------------------------------------------
  226-  277 (54.37/39.30)	RLLD...ID.FLVEDKetgdgkalvhpLQVNYIHQL..............IQGRIVDCTDALAevytCLH
  299-  353 (50.00/84.83)	RLDDhihVDeYIVGSK...........LTVSYWRELtnkdpkselgyrltIQTDPNDCAKQLA....ILH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.32|      19|      21|      14|      32|      14
---------------------------------------------------------------------------
    6-   30 (28.38/19.43)	LEqggavaNFI..PTGQEMAQRQNLIP
   31-   54 (22.94/14.01)	LR...qliDFIiqRTYHELTVLAELLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      53.50|      10|      71|     862|     871|      15
---------------------------------------------------------------------------
  862-  871 (18.45/11.42)	NEKYNLASMV
  912-  921 (17.00/ 9.93)	NSAINAHSMM
  930-  939 (18.06/11.02)	NHNYNLAQIV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07800 with Med14 domain of Kingdom Metazoa
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