<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07798

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMQQSGDKGSWENGLSYECRSLLFKALHNVIERCLLSRDVVRLGKWFVQPSTNSERAIGKSSLHPSFSYAFFVHGDSTVCASMDIREHPPVRPLTMQHLEEALAHQSIPSASGGSNSSSTTTGGSVAPSPGAGSNTNATLATSGPNGMLPGGEDAANGGTVSASSAPLVSKPRSVILAPFGLAGTLTGQSYKANDPQTQKLLDDWSAFYPISNKSVSLSADSADAVPPIVEIMIGGVKMRYPSKYVLVTDMDDWSPPTPPAATNDSCSTTDAATKATTGGPASNNQTTATAAAAAAASALTAASVKREHSAVDVKSERSTGGSGGGVPSSSSSVNSGNNQIGAIVATAGNKDLNGTANGSGRTLSQQQPRHHKSQMTPPLTVPESPSNDLGNPYSMSSALINKSAAVILPERVWQDCIMHAPPGAPLAPPASGHATPAAAAAAAANMTPIGPVKVEPKDTSGGAGVGTGGDENSSGAANGVDANGNSSVWEISNPTAKVYCSCIKSNQKCSTNSTSGMASSLVGGSANAGSTATPYGGPPSYCRNPLSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITLSPHPPASNNPRSVQPGTPSCLDHLDKNTPAPTPTDQHDSKSITASPYHTPSHPGGSGPGGTGGGGGGGGGDQHQQQQQQQGNQQQNHQSQGTGPNAGSNSASSSTSSCNSTASTHSSLKASPRNAGGAGGGGLKVRSDMSLGASTATAATTSIAASGVGGGVPMTPSIHSVYSTAHQTAVANNLASKRESILQMLQSLKRPSLYCKDYETLQTEDIPSTSQLLYDYTSVDAWMNHPVKRMRFAPEESGRLVRQFRTNLDLYANERTSFGGSGGLAGGGCNSLLMRGLESGTEGLSNHHLHGGAGTGGLSGGCGDGMSASGSNGATGGQSVATGGGLLGLGQIKMELGCDGGGVGGGSTPNGTAGGGDRLNGSGGGGVNAGGDNTLLGEHEIKKEKEDKGGSGYSLLTDQDLQPSIDDLNQIFDDGGPFNDDADMHNTPPGSNKSSSGSGNGFSEEGKRYPHSNHHHGVNTGILSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGIAIDTMVDLQMSLSSGGIGGGIGGGIGGVHGTTTLGSLLSGPAVPTVPNLGSPQEEPIDDWSFVFLPPTVCPYVGSSKYAPLANLPSQLAPAPVAPPGANLVYKSTRQKQKEKAAEREQKQKQLREQHQDANGGGDQQQQQQSAQDGHSSSAVGASTVPPAGGTTGGGIISTLLGTPAGLVGSGGLLPMLKQEPSLMVPQPLSTPNSMLGGLNGSASHPYSNPPSQGAQSQQLSRPSSVNSLPGGIVGGGGGGPVGMMSPSPTGAAGGGGGTGLYHPTMGGGIPVPLRQGMSPISPATPGGSMRVPTPGVPLPYPSPLGGAAAGSPNPMAFRRATPLLPPPPYDVAIASPANSSYHSKQFPLDDAGRPGSRGPLTPSGALGPGSNAAGIAGMAADRGAGVGGSAVNGYGVGGGTPGMVNSVTQGTHAGCGGALRSATIEANALLVNMLLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGGDSGLYHALPGTNWMDSVVAANNGGGSEQDGTAAAGGAGGANRNAKMPSGMLAHLGLTGGGPANSSGSSNGASATTPAVTINADSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFFEDEMEITGMAEDPAIHKKSSLFEFLNGTAKAIKSSAADGSSAGGGAATGGGGSGGTGGGTVATNATNSCESLPLTLKVMDLLREQCSMVQSSSNSIHRAVSRYRGPLFGRGADAATVHLLEYVDANDVISLALEQGRLQAINENKLLDQQQQLDQPPGSVTGNGALAVAKGGAGAPAVPRGTMNVHKWPFLRAGGPKSNQDIVRMMKSMQPLLQDAFHKKCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGLLRVGAQRVLKETSNSNLDEWFTNMGVTTATADTQQQRGGAGGKTGAGARPTATGTSGSSTSASSATSSSTTSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHTGSLSSASSGAGSSGGGPGSAGPGSSTSSLGSGQAGAGGSAMGMNRDGPGQSPMPPPPPSTPDPSQPGDKAPNTPKFDHDADNRDQLNASSSSPADAMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPESIRSNISVQIVSLESILELGRARNRLRLSDHMRCLALSVFSQSRKYLAHSNTVKSLTGFGTAANAEQFIRGKDDKNRVPYRLYTPPYVLAKSSEKSENTESFGKPSIKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRARRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPISVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSALSTPQDATCTHILVFPTSAKAQSAQVSFSAIGELDINEDLNNLIMDGDDDDDGMLGASDLLGFWDDLPLQPQMPSRPGSPSQFEGNQQSPGERGSNGAGSRDGYGSQDSEEVGVVLQQPLAIGYLVSTAPTGRMPAWFWSSCPHLENVCPVFLRTALHLHSPTILQNTDDLLQQSQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALAKMNENGADEVAPACNVDLLQPDRTHISAWRDRAEFQHVYRQLFEATAKEDIEAKEDALQWLNVWKVRQNKSVPVCVRCTATVLEAQLFDLRMQREDGDPSATEIKNIYAGAFTRFVNYVTEETQTYQQHRKRTIAQHVRGIGIEPFLVELRHLCAHRSVSIAIDVFRRSAQYCMDWLKAAYWQRELATMVPVTYETLHRAKRPPLSDEFCAVLRTYDAATAGLLRRYTKVQHTRPFLTDPDYEALQEEGKRRGTDKLRVIAQHLLAQFVRNQRTIAHNLTGVRKVCDAVMSNCRYLMQDPARYRQGHWGKLHSAFFRALAETGCLQELFDRLLAVAESEAEDEQNRAMASFWTVKIATGFQLLKEFKKHCRTLHSQRLVFFQELVNGKARRKAIAERLALEWYRQKLQKAAAPQELILGLTVDCPWHLRMDRRQLKTHLNAINQHTMKLLPM
Length3247
PositionMiddle
OrganismAnopheles albimanus (New world malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.395
Instability index49.84
Isoelectric point6.55
Molecular weight340165.97
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
Las1 complex	GO:0090730	IEA:InterPro
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
endonuclease activity	GO:0004519	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
rRNA processing	GO:0006364	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07798
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.86|      23|      23|     921|     943|       1
---------------------------------------------------------------------------
  641-  663 (38.38/10.99)	PGGSGPGGTGGG...GGGGGGDQHQQ
  933-  957 (33.53/ 8.55)	ELGCDGGGVGGGstpNGTAGGGD.RL
 1356- 1388 (29.94/ 6.74)	PTGAAGGGGGTG.lyHPTMGGGMSPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|    1662.25|     210|     211|     367|     576|       3
---------------------------------------------------------------------------
   84-  228 (130.48/33.83)	.........................................................................IRE.HP...PVR.......PL....TmqhlEEALAH..................QSiPS.AS......GGSNSSSTTTGG...........................S.......VAP...S..............................P.GAGSNTNATLAT...S..G.PNG........................................MLPGG...ED.AA.....NGGTVSASSAP...............................LVSKPRSVILAPFGLAGTLTGQSY.....KAND.PQT........................................QKLL......D......DWSAFY......PI............................................S.N.......KSVS.LSADS..ADAVP..................P...I.............
  230-  366 (143.65/38.02)	EIMIGGVKM...RyP..SKYV.LVTD..MDDW......SPP..TP...PAATND....S............CsTTD.AA...TKA.......TT....G....GPASNN..................QT.TAtAA......AAAAASALTAAS..........................VKrehsavdVKSERST..............................G.GSG...GGVPSS...S..SSVN............................................SG...N..........N............................................QIGAIVATAG..NKDLNGTA.....N.................................................GS......G...........R......TL.............................................................................S...........................QQ
  367-  576 (355.84/105.47)	QPRHHKSQM...T.P..PLTV.PESP..SNDL......GNPYSMS...SALINK....SAAVILPERVWQDC.IMH.AP...PGA.......PL....A....PPASGH..................AT.PA.AA......AAAAANMTPIGP..........................VK.......VEPKDTS..............................G.GAGVGTGGDENS...S..GAANG........................................VDANG...NS.SVWEI..SNPTAKVYCSC...............................IKSNQKCSTNSTSGMASSLVGGSA.....NAGS.TAT........................................PYGG......P......PSYCRN......PL............................................SIG.......DSHP.LPSEGSPASAAP......S...........P...MQPS.....SVSQP
  577-  765 (160.18/43.27)	TSVPSGDQL.........ITLsPHPP..ASN........NPRS........................VQ.............PGT.......PS....C....LDHLDK..................NT.PA.PT......PTDQHDSKSITA....................................SPYHTPshpggsgpggtgggggggggdqhqqqqqqqG.....NQQQNHQS...Q..GT..G........................................PNAGS...NS.A..................................................SSSTSSCNSTASTHSSLKASPR.....NAGG.A............................................GG......G......GLKVRS......DM............................................SLG................ASTATAAT......TsiaasgvgggvP...MTPSihsvySTAHQ
  774- 1002 (192.05/53.40)	SKRESILQM...L.Q..SLKR.PSLY..CKDY......E...TLQ...TEDI.P....STSQLLYDYTSVDA.WMN.HP..vKRM.......RF....A....PEESGR..................LV.R...........QFRTNLDLYAN....................................E.RTSF..............................G.GSGGLAGGGCNSllmR..GLESG........................................TEGLS...NH.HL.HG..GAGTGGLSGGC..........................................GDGMSASGSNGAT.....GGQS.VATgggllglgqikmelgcdgggvgggstpngtagggdrlngsGGGG......V......NAGGDN......TL.............................................LG.......E.HE.IKKEKEDKGGSGyslltdQ...........D...LQPS..........
 1004- 1196 (120.80/30.75)	.............................DDLnqifddGGPF..........ND....DA..........D...MHnTP...PGS.......NK....S....SSGSGNgfseegkryphsnhhhgvNT.GI.LS......PKELSQMFPTPPsldphpnsspggggclsdggiaidtmVD.......LQMSLSS..............................G.GIGGGIGG...G...I..GGVHG............................................................TT..............................................TLG......SLLSGPAvptvpNLGSpQEE........................................PIDDwsfvflP......PTVC........PY.............................................VG.......SSKY.APLANLPSQLAP......A...........P...VAPP.....GANLV
 1199- 1355 (167.97/45.75)	STRQKQKEK...A.A..E....REQK..QKQL......RE.........................QH..QDA.NGG.GD...QQQ.......QQ....Q....SAQDGH..................SS.SA..................VGA..........................ST.......VPP...A..............................G.GT...TGGGIIS...TllGTPAG........................................LV..G...SG.GLLPMlkQEPSLMV..P....................................QPLST......PNSMLGG.L.....N.GS.ASH........................................PYSN......P......PSQGAQsqqlsrPS............................................SV........NSLP....GGIVGGGGG......G...........PvgmMSPS..........
 1389- 1650 (189.40/52.56)	SPATPGGSMrvpT.PgvPLPY.P.SPlgGAAA......GSPNPMA...F....R....RATPLLPPPPY.DV.AIA.SP...ANSsyhskqfPLddagR....PGSRGP..................LT.PS.GAlgpgsnAAGIAGMAADRG..........................AG.......VGGSAVN..............................GyGVGGGTPGMVNS.vtQ..GTHAGcggalrsatieanallvnmllydtalnifrdhnfksctlcVCNAG...AK.CVGNI..RGGDSGLYHAL...............................PGTNWMDSVVAANNGGGSEQDGTA.....AAGG.A............................................GG......AnrnakmPSGMLA......HL............................................GLT.......GGGP.ANSSGSSNGASA....................................
 1651- 1876 (148.22/39.47)	........T...T.P..AVTInADSL..QNGY....ldEDPIDCQcgfSAVVNRrmahRAGLFFEDEMEITG.MAE.DPaihKKS.......SL....F....EFLNG....................T.AK.AI......KSSAADGSSAGG.....................................GAATG..............................G.GGSGGTGGGTVA...T..NATNS........................................CESLP...LTlKVMDL......LREQCSM...............................VQSSSNSIHRAVSRYRGPLFGRGA.....DA.............................................................................atvhlleyvdandvislaleqgrlqainenklldqqqqldqppgSVT.......GNGA.LAVAK...GGAG......A...........P...AVPR.....GT...
 2069- 2198 (53.67/ 9.41)	.................................................................................................................................................................................................................................G.GAGGKTGAGA.....R..PTATG........................................TSGSStsaSS.A.......TSSSTTSSGLnellrlyaqtcqqqlapylskvpsdkslldpPESHHTGSLSSASSGAGS...........SGGG............................................PGSA......G......P..GSS......TS............................................SLGsgqagagGSAMgMNRDG..PG..Q......S...........P...MPP...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.85|      55|     210|    2439|    2500|       4
---------------------------------------------------------------------------
 2439- 2500 (80.91/73.58)	PNRARRKRASARR.YGLQKLMDfiLGLISQtvQPwrLVVGR.IGRIGHGELKGWSWlLSKPNLQ
 2649- 2705 (94.93/59.69)	PGERGSNGAGSRDgYGSQDSEE..VGVVLQ..QP..LAIGYlVSTAPTGRMPAWFW.SSCPHLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.56|      55|     501|    2217|    2277|       5
---------------------------------------------------------------------------
 2217- 2277 (89.25/68.79)	PKFDHDADnrDQLNASSSSPADAMriddDGKDPPHIVLYIVEPFT....CGNDSPDVERLACLSL
 2721- 2779 (90.31/54.40)	PTILQNTD..DLLQQSQSSTEHPL....DSNITADVLRYVLEGYNllswLAMDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.41|      17|      19|    2309|    2325|       8
---------------------------------------------------------------------------
 2309- 2325 (29.67/20.37)	LGRARNRLRLSDHMRCL
 2330- 2346 (27.74/18.47)	FSQSRKYLAHSNTVKSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07798 with Med13 domain of Kingdom Metazoa
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