<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07795

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMQREEKQFEMLMEAVLNRLNDLIHAIGGMIHRLETEYETLNWPTFLDNYALISGHVTGLMKILSSEIGTPLRNLTVLPLMLTQERDEALSQLTDGRVAMFSHDLAPDYLRTKPDPGAETRLATHETKANNLTTEAGIKQVAQYNKVISHVWDILNKAKEDWENESSTRPGIQQTSSMADTQALVAAVGVGNGLTVPVVPNAGVMIPPAIRQGSPMGAIPPKFVVKMIIDSPKTTSKTTLLKLMLLRAWKERWTDCQWGINVKTVLTRGVSGDVYNLADAIIQQAVVGSGANMLFLSYLKHSLCAHLISHAAVLNRIAKYEHFDKHHCLIALLDFLQSIIDGVTCRGKQEESILTKAVVSLVHWLIQIYECAIKSYAESRALTAEEETVVQKVAIVLERIVDSPFLLGVLSIGKYETPDQFLALQHRFNGINNLTITTGYVAQVPGSQKNPVTVTDCMRKLVLIELDASEMKLFDGGVVEPITYCLQPLLAVEVLLNPMSDTAQYVSQLINLRRLKGFSNARLYCELVRGCFMSLNNVEGTSKESLLCAFAFIRVPHIMRQIHGRLNGKEQTEETTNQTYSVDVVEAFEMLLQDTPVLDYMDMKCACNVVECLLKELAKHNLVSEIHVKQFVTQREPITLGLQKLETSNTQLAMMLKFVFRVESPLAGILKALSTDFSKVQDALLAMLCQVLTGNGLDLVLSVASVEGKFKALVSGLLKCNDYAKQATTVELGKAPATRAALFDVTFMMLAFVAQSYGSDAILAEGGNTFFEKWVREFMVERKKTKSPMTMVKQADPMVLEELIMALNNTDAGLKASNLRWEDICYTIPALLHQVLMAWENETLSPVEIKKMLDGLKAQFCSFAVCSASWLCAYMQMVRQDEQVKPMNMVQQLCSALSGPQAEEWQQQDYGKDRFTLMGQIIRKMQQEFQRMPQINPKLKALFPSQHMVSHLPLEEQFEEAWKAVAERGWLPIETTFLFDTLLQSCGPLWLVEKLIAKLFLCKYVRELNKTMDLIFAIMHLDIERCTIALLSQLVPMMLLNKQQTPEIVDPQSRVLAKLCVYCIMVTMENSLTTTKKRARAAGGTADAEDLDSLCSSAKLRKIELDGMGVGCASDPVTAEFSLDSALDGNAWEMTTVSLKEPLQSCLQTLFRTFTQYITTNELSPKVYFVFQFLSLLVEIGRDRIMCVLKLIPNGLIQNLLKINATDEVTVGLILSSLYWVTGFGTLLVGTMSGATRIITRDPWSTGLTLDLIERYRVTILFLPPPHLNQMLVNGMIGIADFSSVRQLLTGGGPLPDEVKRSMERYLTHPEAAVLPCFGLTEFCGVSMDTARRYKPDSVGEVSPCVEAKIVGEDDMPLDSDQEGELLLRSDFMFLGYYGNPSATSEVLDPDGWLRTGDIARYDADGMFYIVSRKKEIMKYGGYQVSPLELEQTIFRLFGEGVGSHTRALRLVCVAGVHERGNDLPVTLAVRLASASISEQEIVDGVADVVADYKRLRGGVFFVDHLPLTSSGKIARKRLYDLSTTTGRQFAMSDVCLLRNIQLRKDSIKL
Length1549
PositionHead
OrganismAnopheles albimanus (New world malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy0.044
Instability index36.69
Isoelectric point5.79
Molecular weight172736.99
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07795
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.61|      10|      22|    1219|    1228|       1
---------------------------------------------------------------------------
 1219- 1228 (19.11/ 9.64)	WVTGFGTLLV
 1243- 1252 (18.50/ 9.11)	WSTGLTLDLI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     282.10|      71|     150|     448|     518|       2
---------------------------------------------------------------------------
  385-  431 (38.97/15.83)	........................................EETVVQKVAIVLERIVDSPFLLG..VLS.IGKYetP.DQFLALQhRFNGIN
  448-  518 (118.40/60.81)	KNP.......VTVTDCMRK.LVLIELDASEM......KLFDGGVVEPITYCLQPLLAVEVLLN..PMSDTAQY..V.SQLINLR.RLKGFS
  542-  598 (36.96/14.69)	KESllcafafIRVPHIMRQ..IHGRLNGKEQteettnQTYSVDVVE..........AFEMLLQdtPVLD......................
  603-  673 (87.77/43.46)	KCA.......CNVVECLLKeLAKHNL.VSEI....hvKQFVTQ.REPITLGLQKLETSNTQLA..MMLKFVFR..VeSPLAGI...LKALS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     256.76|      86|     158|     952|    1047|       3
---------------------------------------------------------------------------
  952- 1047 (124.36/106.19)	PLEEQFEEAwKAVAERGWLpiETTFLFDTLLQSCgplwlVEKLIaKLFlCKYV..RELNKTMDLIFAIMHLDIE..RCTIALLSQLVP....MMLLNKQQTPEI
 1115- 1208 (132.40/80.45)	PVTAEFSLD.SALDGNAWE..MTTVSLKEPLQSC.....LQTLF.RTF.TQYIttNELSPKVYFVFQFLSLLVEigRDRIMCVLKLIPngliQNLLKINATDEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.85|      34|     675|     129|     164|       5
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  129-  164 (55.69/48.22)	NNltTEAGIKQVA.QYNKVISHVWDILNKAKEDWENE
  807-  841 (58.17/43.31)	NN..TDAGLKASNlRWEDICYTIPALLHQVLMAWENE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.69|      21|     500|     182|     203|       6
---------------------------------------------------------------------------
  182-  203 (30.71/25.75)	ALVAAVGVGNGLTVpVVPNAGV
  685-  705 (35.98/24.15)	AMLCQVLTGNGLDL.VLSVASV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07795 with Med8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA