<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07795

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMQREEKQFEMLMEAVLNRLNDLIHAIGGMIHRLETEYETLNWPTFLDNYALISGHVTGLMKILSSEIGTPLRNLTVLPLMLTQERDEALSQLTDGRVAMFSHDLAPDYLRTKPDPGAETRLATHETKANNLTTEAGIKQVAQYNKVISHVWDILNKAKEDWENESSTRPGIQQTSSMADTQALVAAVGVGNGLTVPVVPNAGVMIPPAIRQGSPMGAIPPKFVVKMIIDSPKTTSKTTLLKLMLLRAWKERWTDCQWGINVKTVLTRGVSGDVYNLADAIIQQAVVGSGANMLFLSYLKHSLCAHLISHAAVLNRIAKYEHFDKHHCLIALLDFLQSIIDGVTCRGKQEESILTKAVVSLVHWLIQIYECAIKSYAESRALTAEEETVVQKVAIVLERIVDSPFLLGVLSIGKYETPDQFLALQHRFNGINNLTITTGYVAQVPGSQKNPVTVTDCMRKLVLIELDASEMKLFDGGVVEPITYCLQPLLAVEVLLNPMSDTAQYVSQLINLRRLKGFSNARLYCELVRGCFMSLNNVEGTSKESLLCAFAFIRVPHIMRQIHGRLNGKEQTEETTNQTYSVDVVEAFEMLLQDTPVLDYMDMKCACNVVECLLKELAKHNLVSEIHVKQFVTQREPITLGLQKLETSNTQLAMMLKFVFRVESPLAGILKALSTDFSKVQDALLAMLCQVLTGNGLDLVLSVASVEGKFKALVSGLLKCNDYAKQATTVELGKAPATRAALFDVTFMMLAFVAQSYGSDAILAEGGNTFFEKWVREFMVERKKTKSPMTMVKQADPMVLEELIMALNNTDAGLKASNLRWEDICYTIPALLHQVLMAWENETLSPVEIKKMLDGLKAQFCSFAVCSASWLCAYMQMVRQDEQVKPMNMVQQLCSALSGPQAEEWQQQDYGKDRFTLMGQIIRKMQQEFQRMPQINPKLKALFPSQHMVSHLPLEEQFEEAWKAVAERGWLPIETTFLFDTLLQSCGPLWLVEKLIAKLFLCKYVRELNKTMDLIFAIMHLDIERCTIALLSQLVPMMLLNKQQTPEIVDPQSRVLAKLCVYCIMVTMENSLTTTKKRARAAGGTADAEDLDSLCSSAKLRKIELDGMGVGCASDPVTAEFSLDSALDGNAWEMTTVSLKEPLQSCLQTLFRTFTQYITTNELSPKVYFVFQFLSLLVEIGRDRIMCVLKLIPNGLIQNLLKINATDEVTVGLILSSLYWVTGFGTLLVGTMSGATRIITRDPWSTGLTLDLIERYRVTILFLPPPHLNQMLVNGMIGIADFSSVRQLLTGGGPLPDEVKRSMERYLTHPEAAVLPCFGLTEFCGVSMDTARRYKPDSVGEVSPCVEAKIVGEDDMPLDSDQEGELLLRSDFMFLGYYGNPSATSEVLDPDGWLRTGDIARYDADGMFYIVSRKKEIMKYGGYQVSPLELEQTIFRLFGEGVGSHTRALRLVCVAGVHERGNDLPVTLAVRLASASISEQEIVDGVADVVADYKRLRGGVFFVDHLPLTSSGKIARKRLYDLSTTTGRQFAMSDVCLLRNIQLRKDSIKL
Length1549
PositionHead
OrganismAnopheles albimanus (New world malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy0.044
Instability index36.69
Isoelectric point5.79
Molecular weight172736.99
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07795
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.61|      10|      22|    1219|    1228|       1
---------------------------------------------------------------------------
 1219- 1228 (19.11/ 9.64)	WVTGFGTLLV
 1243- 1252 (18.50/ 9.11)	WSTGLTLDLI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     282.10|      71|     150|     448|     518|       2
---------------------------------------------------------------------------
  385-  431 (38.97/15.83)	........................................EETVVQKVAIVLERIVDSPFLLG..VLS.IGKYetP.DQFLALQhRFNGIN
  448-  518 (118.40/60.81)	KNP.......VTVTDCMRK.LVLIELDASEM......KLFDGGVVEPITYCLQPLLAVEVLLN..PMSDTAQY..V.SQLINLR.RLKGFS
  542-  598 (36.96/14.69)	KESllcafafIRVPHIMRQ..IHGRLNGKEQteettnQTYSVDVVE..........AFEMLLQdtPVLD......................
  603-  673 (87.77/43.46)	KCA.......CNVVECLLKeLAKHNL.VSEI....hvKQFVTQ.REPITLGLQKLETSNTQLA..MMLKFVFR..VeSPLAGI...LKALS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     256.76|      86|     158|     952|    1047|       3
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  952- 1047 (124.36/106.19)	PLEEQFEEAwKAVAERGWLpiETTFLFDTLLQSCgplwlVEKLIaKLFlCKYV..RELNKTMDLIFAIMHLDIE..RCTIALLSQLVP....MMLLNKQQTPEI
 1115- 1208 (132.40/80.45)	PVTAEFSLD.SALDGNAWE..MTTVSLKEPLQSC.....LQTLF.RTF.TQYIttNELSPKVYFVFQFLSLLVEigRDRIMCVLKLIPngliQNLLKINATDEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.85|      34|     675|     129|     164|       5
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  129-  164 (55.69/48.22)	NNltTEAGIKQVA.QYNKVISHVWDILNKAKEDWENE
  807-  841 (58.17/43.31)	NN..TDAGLKASNlRWEDICYTIPALLHQVLMAWENE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.69|      21|     500|     182|     203|       6
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  182-  203 (30.71/25.75)	ALVAAVGVGNGLTVpVVPNAGV
  685-  705 (35.98/24.15)	AMLCQVLTGNGLDL.VLSVASV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07795 with Med8 domain of Kingdom Metazoa
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