<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07794

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSTEMRIVKLFEEVLVSGIYGISVNCNAQNVVWCLQEDKNIPNCDEEEQRKRADEGYKKIAALFAAMTPEVREVSIRSYLGYCGTMNHQNQVQKYLRVMARLVALNIIPAKLVCDQLMGSEKLTYKNTCFWIESFRLVRKIIGGVDYKGVREIMKSCKEKALSFPVNVSVNILPQLLELIELIEHIFNRSACLLPAYFIINEIKKTDYQNMHWRVSNLIANFIEEFVAVAQMLSIIGHSSMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDDELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMEYSEKESQTTGGQGNGGPNGEHDDGASSHTQWVWLHLSSQLIYFVLFQFATFQNIVNTLHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPVLKLYDILYPEKEPLPVPDYNNPYCTHQMAPTCIWIHLMKRAQTENYNINRPIPIALRLHFDYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMSGQPLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSHAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYVSEPKPPGNIVSAESEELNRALILTLARSMHITGTGSDPQSSAWCKDLLQNIMVNTPHAWPQHTLLCFPQVLNEFFMQHNIPKESKQLLKKTVDEEFRNWASMTNENDIIAHFGMAVNPPLFLCLVFKMIIETDAISPVAYKILERIGARALSTHLRKLCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIVTIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTSEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPTLPVYFGNVCLRFLPVLDIIVHRYLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYEVKLRDRPLLKKRLVGTVVGSLKDVRPENWALTEQYQAYMVKKENDNANWVPELSYYIQLVGRMQDNWRFNEFPNPPAHALYVTCVELLGLPVGPSVVANSIIDVLVKGYTVVPTGVVHNWANTIGLIMAALPEAYWCVIYERMQEALRSPAMKQWTYRQSPFEMFNFKVVREAMLDRSYVTVLAIVHSTFHHFGIGQLATITDSIKEKLKPLVQTEYQLIYLCHVVGPFLNRLSVERARAVSDITLMLYELLEQVDKAQPTQPLRYMDPICDLLYHIKYMFVGDTMKTDLEAIIRRLRPALQMRLRFITRLNVEEIGVDQNANAGALAGGGGVAAGGTGVPGGGGAVGGSMPTQQTGSTQMATGTNVGGIGGGVGIGTQSQAGQGVAVGAAVAAAAAAAAAAQQSAVGMVNQNVALQQQLQQQKQQQQQMGQGMQQHH
Length1481
PositionTail
OrganismAnopheles albimanus (New world malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.09
Grand average of hydropathy-0.083
Instability index44.67
Isoelectric point7.89
Molecular weight167713.22
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07794
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.69|      15|      17|    1025|    1039|       1
---------------------------------------------------------------------------
 1008- 1032 (21.64/10.51)	TQLSKTLdvildhlgslY..KFHDRPI
 1033- 1051 (20.05/ 9.25)	TYLYNTL........hyYevKLRDRPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.42|      13|      17|    1078|    1092|       2
---------------------------------------------------------------------------
 1078- 1092 (21.08/17.11)	YQAYMVKKENDnaNW
 1098- 1110 (26.33/14.69)	YYIQLVGRMQD..NW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.41|      15|      18|     272|     289|       3
---------------------------------------------------------------------------
  272-  289 (19.61/18.94)	NLPYDDELLqpqARLLRF
  292-  306 (27.81/16.17)	QQPYSRDMV...CSMLNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      85.98|      13|      18|    1360|    1372|       4
---------------------------------------------------------------------------
 1360- 1372 (19.98/ 9.34)	GVDQNANAGALAG
 1380- 1392 (23.85/12.54)	GTGVPGGGGAVGG
 1400- 1412 (21.66/10.73)	GSTQMATGTNVGG
 1420- 1432 (20.49/ 9.76)	GTQSQAGQGVAVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.62|      10|      39|     315|     326|       5
---------------------------------------------------------------------------
  315-  324 (17.67/11.75)	AALEEQLVWL
  355-  364 (19.95/ 6.30)	ASSHTQWVWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.74|      55|      78|     548|     602|       7
---------------------------------------------------------------------------
  548-  602 (96.78/59.73)	GQPLPTAPLSMR..VLDS.LTIHS.KMSLIHS.IVMHMIKQAQNKSSIPNGNNMA.PALVE
  623-  683 (77.96/46.67)	GQLLPQVFKSHAwgILYTlLEMFSyRMHHIHShYRVQLLTHLHSLASVPHTNQMQlHSCVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.79|      18|      19|     733|     750|       8
---------------------------------------------------------------------------
  733-  750 (33.90/22.17)	RSMHITGTGSDPQSSAWC
  755-  772 (34.89/23.05)	QNIMVNTPHAWPQHTLLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.91|      13|      18|    1128|    1140|       9
---------------------------------------------------------------------------
 1128- 1140 (21.83/11.31)	VELL..GLPVGPSVV
 1145- 1159 (17.08/ 7.26)	IDVLvkGYTVVPTGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.88|      17|      19|    1278|    1295|      11
---------------------------------------------------------------------------
 1278- 1294 (27.88/19.94)	VERA......RAVSDITLMLYEL
 1298- 1320 (26.00/12.53)	VDKAqptqplRYMDPICDLLYHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.32|      31|     328|     488|     527|      12
---------------------------------------------------------------------------
  488-  527 (42.30/46.21)	DYLQHLAMpSNNPTLFMGSEYRFALlcnaystQTDYFSrP
  813-  843 (57.02/32.92)	DIIAHFGM.AVNPPLFLCLVFKMII.......ETDAIS.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.05|      53|     749|     167|     226|      14
---------------------------------------------------------------------------
  167-  226 (72.65/77.64)	NVSVNILpQLLeLIELIEhIFNRsaclLPAYFIINEIKKTDYQNMHWRVSNLIANFIEEF
  918-  970 (97.41/70.64)	QVSFYII.QLL.LLKTSE.FRNR....VQEFITINSPEHWKQNNWHERHLAFHQKFPEKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.52|      22|     785|      94|     118|      15
---------------------------------------------------------------------------
   94-  118 (32.00/29.77)	KYL.RVMARlvALNIIPAKLvCDQLM
  847-  869 (35.52/21.53)	KILeRIGAR..ALSTHLRKL.CDYLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.88|      17|     748|      50|      70|      18
---------------------------------------------------------------------------
   50-   70 (25.34/25.89)	RKRADEGYKKiaalFAAMTPE
  795-  811 (31.54/20.91)	KKTVDEEFRN....WASMTNE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07794 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA