<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07794

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSTEMRIVKLFEEVLVSGIYGISVNCNAQNVVWCLQEDKNIPNCDEEEQRKRADEGYKKIAALFAAMTPEVREVSIRSYLGYCGTMNHQNQVQKYLRVMARLVALNIIPAKLVCDQLMGSEKLTYKNTCFWIESFRLVRKIIGGVDYKGVREIMKSCKEKALSFPVNVSVNILPQLLELIELIEHIFNRSACLLPAYFIINEIKKTDYQNMHWRVSNLIANFIEEFVAVAQMLSIIGHSSMLPIVEHSSYADNLIIPWKLDPDTLKLSLRGNLPYDDELLQPQARLLRFVLQQPYSRDMVCSMLNFQKQQKQKCAALEEQLVWLVLNAMEYSEKESQTTGGQGNGGPNGEHDDGASSHTQWVWLHLSSQLIYFVLFQFATFQNIVNTLHEKLAVRNLRRGRDHLMWVFLQYISGSIQKHSILNFLPVLKLYDILYPEKEPLPVPDYNNPYCTHQMAPTCIWIHLMKRAQTENYNINRPIPIALRLHFDYLQHLAMPSNNPTLFMGSEYRFALLCNAYSTQTDYFSRPMQALIDTILGNSKNPQANMSGQPLPTAPLSMRVLDSLTIHSKMSLIHSIVMHMIKQAQNKSSIPNGNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSHAWGILYTLLEMFSYRMHHIHSHYRVQLLTHLHSLASVPHTNQMQLHSCVESTALRLIIGLGSVEVQAQLSRYVSEPKPPGNIVSAESEELNRALILTLARSMHITGTGSDPQSSAWCKDLLQNIMVNTPHAWPQHTLLCFPQVLNEFFMQHNIPKESKQLLKKTVDEEFRNWASMTNENDIIAHFGMAVNPPLFLCLVFKMIIETDAISPVAYKILERIGARALSTHLRKLCDYLLFEVANSGGGAHVNKCVDTINDMIWKYNIVTIDRLVLCLILRTLDGNEAQVSFYIIQLLLLKTSEFRNRVQEFITINSPEHWKQNNWHERHLAFHQKFPEKFAPDESVSHPTLPVYFGNVCLRFLPVLDIIVHRYLEVPTQLSKTLDVILDHLGSLYKFHDRPITYLYNTLHYYEVKLRDRPLLKKRLVGTVVGSLKDVRPENWALTEQYQAYMVKKENDNANWVPELSYYIQLVGRMQDNWRFNEFPNPPAHALYVTCVELLGLPVGPSVVANSIIDVLVKGYTVVPTGVVHNWANTIGLIMAALPEAYWCVIYERMQEALRSPAMKQWTYRQSPFEMFNFKVVREAMLDRSYVTVLAIVHSTFHHFGIGQLATITDSIKEKLKPLVQTEYQLIYLCHVVGPFLNRLSVERARAVSDITLMLYELLEQVDKAQPTQPLRYMDPICDLLYHIKYMFVGDTMKTDLEAIIRRLRPALQMRLRFITRLNVEEIGVDQNANAGALAGGGGVAAGGTGVPGGGGAVGGSMPTQQTGSTQMATGTNVGGIGGGVGIGTQSQAGQGVAVGAAVAAAAAAAAAAQQSAVGMVNQNVALQQQLQQQKQQQQQMGQGMQQHH
Length1481
PositionTail
OrganismAnopheles albimanus (New world malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.09
Grand average of hydropathy-0.083
Instability index44.67
Isoelectric point7.89
Molecular weight167713.22
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07794
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.69|      15|      17|    1025|    1039|       1
---------------------------------------------------------------------------
 1008- 1032 (21.64/10.51)	TQLSKTLdvildhlgslY..KFHDRPI
 1033- 1051 (20.05/ 9.25)	TYLYNTL........hyYevKLRDRPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.42|      13|      17|    1078|    1092|       2
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 1078- 1092 (21.08/17.11)	YQAYMVKKENDnaNW
 1098- 1110 (26.33/14.69)	YYIQLVGRMQD..NW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.41|      15|      18|     272|     289|       3
---------------------------------------------------------------------------
  272-  289 (19.61/18.94)	NLPYDDELLqpqARLLRF
  292-  306 (27.81/16.17)	QQPYSRDMV...CSMLNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      85.98|      13|      18|    1360|    1372|       4
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 1360- 1372 (19.98/ 9.34)	GVDQNANAGALAG
 1380- 1392 (23.85/12.54)	GTGVPGGGGAVGG
 1400- 1412 (21.66/10.73)	GSTQMATGTNVGG
 1420- 1432 (20.49/ 9.76)	GTQSQAGQGVAVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.62|      10|      39|     315|     326|       5
---------------------------------------------------------------------------
  315-  324 (17.67/11.75)	AALEEQLVWL
  355-  364 (19.95/ 6.30)	ASSHTQWVWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.74|      55|      78|     548|     602|       7
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  548-  602 (96.78/59.73)	GQPLPTAPLSMR..VLDS.LTIHS.KMSLIHS.IVMHMIKQAQNKSSIPNGNNMA.PALVE
  623-  683 (77.96/46.67)	GQLLPQVFKSHAwgILYTlLEMFSyRMHHIHShYRVQLLTHLHSLASVPHTNQMQlHSCVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.79|      18|      19|     733|     750|       8
---------------------------------------------------------------------------
  733-  750 (33.90/22.17)	RSMHITGTGSDPQSSAWC
  755-  772 (34.89/23.05)	QNIMVNTPHAWPQHTLLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.91|      13|      18|    1128|    1140|       9
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 1128- 1140 (21.83/11.31)	VELL..GLPVGPSVV
 1145- 1159 (17.08/ 7.26)	IDVLvkGYTVVPTGV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.88|      17|      19|    1278|    1295|      11
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 1278- 1294 (27.88/19.94)	VERA......RAVSDITLMLYEL
 1298- 1320 (26.00/12.53)	VDKAqptqplRYMDPICDLLYHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.32|      31|     328|     488|     527|      12
---------------------------------------------------------------------------
  488-  527 (42.30/46.21)	DYLQHLAMpSNNPTLFMGSEYRFALlcnaystQTDYFSrP
  813-  843 (57.02/32.92)	DIIAHFGM.AVNPPLFLCLVFKMII.......ETDAIS.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.05|      53|     749|     167|     226|      14
---------------------------------------------------------------------------
  167-  226 (72.65/77.64)	NVSVNILpQLLeLIELIEhIFNRsaclLPAYFIINEIKKTDYQNMHWRVSNLIANFIEEF
  918-  970 (97.41/70.64)	QVSFYII.QLL.LLKTSE.FRNR....VQEFITINSPEHWKQNNWHERHLAFHQKFPEKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.52|      22|     785|      94|     118|      15
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   94-  118 (32.00/29.77)	KYL.RVMARlvALNIIPAKLvCDQLM
  847-  869 (35.52/21.53)	KILeRIGAR..ALSTHLRKL.CDYLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.88|      17|     748|      50|      70|      18
---------------------------------------------------------------------------
   50-   70 (25.34/25.89)	RKRADEGYKKiaalFAAMTPE
  795-  811 (31.54/20.91)	KKTVDEEFRN....WASMTNE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07794 with Med23 domain of Kingdom Metazoa
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