<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07790

Description Uncharacterized protein
SequenceMGVPKFFRYISERYPCLSELLRENQAADFMDLNRLQVPEFDNLYLDMNGIIHNCSHPNDADVTYRISEEMIFEGIFHYVEYLFKMIRPQKVFFIAVDGVAPRAKMNQQRGRRFRSAHEAAEQLKAAIAKGETIPDEDRFDSNCITPGTAFMVRLQKALEHFIQVKIATDVLWKACTVILSGHETPGEGEHKIMEYIRHAKAQPGFNPNTRHCLYGLDADLIMLGLCTHERFFSLLREEVKFGKNDKKATVMKEIRFYLLHLTLLSEYLELEFGSLRNQLRFPFDIHKLIDDWVLMIYLVGNDFIPHLPHLHINENALPTLYRAYMDVLPEMDGYINESGILNLPRLQQLMRRLAVFDRDTFLEHYTDLKYLESKCGKNNLEAFDVSADEIISTSKANDDLMALIMSSKMLDSGDEDEESQISVGDIENDPVLFEKEFQSYKRNYYMSKMGYADFNEETRAEQAECYIRALQWTLHYYYRGVVSWSWYYPHHYAPFISDVDHFDHLKLEFDMARPFLPFQQLLSVLPAASKSHLPAAYHQLMVDPNSPVYDFYPPEFSTDLNGKQQSWEAVVLIPFIDERRLLKAMKNCDEYLTDEEKQRNVHGPMIQYRYDANQQDPLEAKYGFERIDMLPVKRTEIFRDDLHVTESNLVLGPSKGSIQEGYATGFPTFKHLPYHGKLKEMRVKVFNFPSKNDSMVVCLDDAAKQLPDTATLAKELLDRTVYVSWPHLMEAKVDSVSDKNQLFKRINEAEKVDERMFNIWCKSITEHNENRLALNVGQINQLVNVRTCVGTEYVLQGDGFVLKRLWNNVAMPYPAQCIVREVKDVMKQQDSYISMEKMFPLGSTIFLRATDCYGCMGEVANISDNRIQGKFLVHEEPEVREVFQMHKQSLQSYRSINDTAALLGISVSVLLQLTGTILVAHGGHRSLNVENEKTVNIGLRLRMKSKNEAAVGFCRLMHNRIWVFSDRTVNLLQRYDQQAPGLFEKLEAVNNKVHFETDLFGEGNEGKLDELHKWLKEQEHNEAERRSCSIELLERNAIERLVTLVDEHNAKQTPRVRTMLVPPRDLLRPGMRKAKTLDPNAHFELLDRVVVASEAEDAPLGRRGTIIGIHKVTDPNPVRREAIGQEDNYYEVLFDQSFTKGVSVYGLTGTAKRVQRMAQGALLNISYGRASNGYQRGGKQSSAAEVGPTLPTVLGSMSNNQNGPQSSIQHRVNERIGKRNGTRKVPNEKLYPQENRPNEPSSVKPPGSVTMQQATEPQRPMEKQVTAPNNVSSADVQQQQRKNEFERFWKKLKESTNNSAFDENDIKHIAQVMSNSSLQPESNAAVLSDKTEKPQSVGTPVHPDGDQMTGMLKKWLGINDRREEGPSQQTGDGASLVQPPLASLPKPPLQWRNKDKELGDRKYEQRYQGSRRPGGVDAGGSISNPNVRPQMTPVVHPTQFNMQTMFMRPPCFAVQQQQQFYGHPKMQQQPYFIQRAPDATMVHGRGGVQSGGYAPPPPRRPVWQSVPPPLQPLPPHIAIESKPISALFSDAPAAPMMQPYPNRGPIGPQNLSYNRNNPAGNGAFVPLQAMKKNAKIRAATTNNGNNSNAGTVLEAWNETTKASVPAPSGKRKSNPKTAGAPTATAAASNETNERNASRKGERVKEVIQKANSDRNVTVEQPIEVSDMDSKTAQQQASKGLPPPSDEKHKGSSQEQTLATNGKQATDAGNGSTVLKKLRVLRSSVGQVFESLGTGVRIDHGEEGKEQKFLQELQELLNAVNANLKDFESCIGDLTPPAAPLNLANSAFLSLETNLERQALYPHLVQSYKWHDKLHEYSTFASTLLQQNSLKRSYYTNTKRRRSLPSSHLATPQMVDNLIGSIHYNNMNLKIVRPFMTNAILHITIARVLRAAVILKGLLIEWVTVKGYEESLLDGIDEHWTESRHQVFRKVQDHAHSAMLHFFSPTLPELAIRSFITWFRSYVTLFADPCKKCGKHLHNTLPPTWRDLRTLEPFHEECKQ
Length1999
PositionTail
OrganismAnopheles albimanus (New world malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.08
Grand average of hydropathy-0.558
Instability index48.94
Isoelectric point7.26
Molecular weight227095.33
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
5'-3' exonuclease activity	GO:0008409	IEA:InterPro
nucleic acid binding	GO:0003676	IEA:InterPro

GO - Biological Process
nuclear-transcribed mRNA catabolic process	GO:0000956	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07790
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     253.53|      61|      71|    1405|    1475|       1
---------------------------------------------------------------------------
 1361- 1404 (69.67/28.98)	RREEGPSQQTG.D.GASLVQPPLASLPKP...PLQW..............RNK...DKELGDRK...YE...
 1405- 1470 (104.22/63.18)	QRYQGSRRPGGVDAGGSISNPNVRPQMTPVVHPTQFnMQTMfmrPPCFAVQQQ...QQFYGHPK...MQqQP
 1483- 1539 (79.63/44.30)	......HGRGGVQSGGYAPPPPRRPVWQSVPPP....LQPL...PPHIAIESKpisALFSDAPAapmM..QP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.18|      40|      71|    1602|    1641|       2
---------------------------------------------------------------------------
 1566- 1590 (28.69/14.19)	.....PLQAMKKNAK.......................IRAATTNNGNNSNAG....
 1602- 1641 (66.40/43.35)	ASVPAPSGKRKSNPKTA.................GAPTATAAASNETNERNASRKGE
 1656- 1709 (47.09/28.42)	VTVEQPIEVSDMDSKTAqqqaskglpppsdekhkGSSQEQTLA...TNGKQATDAGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.44|      18|      59|     819|     836|       4
---------------------------------------------------------------------------
  819-  836 (32.40/20.91)	VREVKDVMKQQ.DSYISME
  879-  897 (29.04/17.96)	VREVFQMHKQSlQSYRSIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.08|      44|      70|     255|     298|       8
---------------------------------------------------------------------------
  255-  298 (76.80/52.62)	RFYLLHLTLLSEYLE....LEFGSLRNQLR..FPFDIHKLIDDWVLMIYL
  322-  371 (67.28/45.07)	RAYMDVLPEMDGYINesgiLNLPRLQQLMRrlAVFDRDTFLEHYTDLKYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.31|      53|      59|    1013|    1065|      10
---------------------------------------------------------------------------
 1013- 1065 (88.40/62.37)	KWLKEQEHNEAERRSCSIELLERNAIERLVTLVDEHNAKQTPRVRTMLVPPRD
 1075- 1127 (86.92/61.18)	KTLDPNAHFELLDRVVVASEAEDAPLGRRGTIIGIHKVTDPNPVRREAIGQED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.00|      36|      42|    1795|    1836|      17
---------------------------------------------------------------------------
 1795- 1836 (54.46/51.52)	ERQALYP..HLVqSYKWHDKLheystFASTLLQQNSLK..RSYYTN
 1838- 1877 (56.53/35.82)	KRRRSLPssHLA.TPQMVDNL.....IGSIHYNNMNLKivRPFMTN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07790 with Med27 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSDAPAAPMMQPYPNRGPIGPQNLSYNRNNPAGNGAFVPLQAMKKNAKIRAATTNNGNNSNAGTVLEAWNETTKASVPAPSGKRKSNPKTAGAPTATAAASNETNERNASRKGERVKEVIQKANSDRNVTVEQPIEVSDMDSKTAQQQASKGLPPPSDEKHKGSSQEQTLATNGKQATDAGNGST
2) HPKMQQQPYFIQRAPDATMVHGRGGVQSGGYAPPPPRRPVWQSVPPPLQPLPPHIAI
3) ISYGRASNGYQRGGKQSSAAEVGPTLPTVLGSMSNNQNGPQSSIQHRVNERIGKRNGTRKVPNEKLYPQENRPNEPSSVKPPGSVTMQQATEPQRPMEKQVTAPNNVSSADVQQQQRKNEFERFWKKLKESTNNSAFDENDIKHIAQVMSNSSLQPESNAAVLSDKTEKPQSVGTPVHPDGDQMTGMLKKWLGINDRREEGPSQQTGDGASLVQPPLASLPKPPLQWRNKDKELGDRKYEQRYQGSRRPGGVDAGGSISNPNVRPQMTPVVHPTQF
1528
1463
1165
1712
1519
1440










Molecular Recognition Features






MoRF SequenceStartStop




1) FERFWKKLK
2) MLKKWLGI
1285
1351
1293
1358