<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07789

Description THO complex subunit 3
SequenceMDGSKTQLEELQEYFKTHNNKREASKAHTAKVHSVGWNCDGRRLASGSFDKTVAVFTLDRDRLNKENTYRGHTGSVDQLCWHASMPDLLSTASGDKTVRIWDVRVGKCATFINTKGENINITWSPDGHTIAVGNKEDLVTFIDTRTHKIRAEEQFSFEVNEIAWSNGSDLFFLTNGQGCVHILNYPNLELQQILKAHPSTCICIEFDPTGRYFATGSADALVSLWDAEELACLRVFSRLDWPVRTISFSHDGKLLASASEDLMIDIGDTESGEKVAHIPVDAATFTVAWHPKQYILAYACDDKDANDRRRDAGSLKKMLRRQARLRREYLFRKAVEGKHKTLQDKKERIKRSLQEHIPIHGDLKKDALELQEKLKWTDEGPKRAGEISGESGGANTVDSKDDEYRYAGCEDPKIMITTSRDPSSRLKQFVKELRLIFPNAQRMNRGNFETKQLVHACRANNVTDFIIVHEHRGVPDNLIICHLPYGPTASFNMSGVVMRHDIPDIGPMSEQKPHLVFHNFKTKLAERTMSILRYLFPVPKEDSKRVITFANHDDFISFRHHTYRMVDRELELTEVGPRFQLKLYQIKLGTLDELDAADTEWVYRPYMNTAAKRRFLSDEDGWQQEDEPEGRMSSYHLSTRERLLAIVNDIEIVAKELIENTIAPKAQKMSSADHTQLVELLVLKDKELKSTLQLAADQAGIEKKMDSLREQVRKQDEEINQLQKQLKEAEQILATSIFQARQKLASIAKANKRPVSSEDLIKFAHRISASHAICAPLTWQQGDLRRPYPTDIEMRLGFLGKSDLNINGHNLQHPSSLNEMHRNAAAAASGAAGGTGGEIPVPSQNQFTWHSSGELHMSMGAGGGSVSLDTRAHKDASQDDVEVMSTESSSSSSSDSQ
Length897
PositionMiddle
OrganismAnopheles albimanus (New world malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy-0.588
Instability index49.97
Isoelectric point6.42
Molecular weight101171.86
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
rRNA primary transcript binding	GO:0042134	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro
translation initiation factor activity	GO:0003743	IEA:UniProtKB-KW

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
rRNA processing	GO:0006364	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07789
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.51|      19|      92|     155|     186|       1
---------------------------------------------------------------------------
  165-  186 (30.17/21.61)	SNGSDLFF....LTNGQGCVHIlnyP
  257-  279 (27.33/19.19)	SASEDLMIdigdTESGEKVAHI...P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     298.73|      95|     108|     286|     389|       2
---------------------------------------------------------------------------
  286-  389 (143.72/107.35)	TVAWHPKQYILAyACDD.KDANDRRRDAGSLKKMLRRQARLrreyLFRKAV...EGKHKTLQDKKERIKRSLQEHIPIHGDLK.KDALeLQEKLKWtdeGPKRAGEISG
  396-  495 (155.01/91.01)	TVDSKDDEYRYA.GCEDpKIMITTSRDPSSRLKQFVKELRL....IFPNAQrmnRGNFETKQLVHACRANNVTDFIIVHEHRGvPDNL.IICHLPY...GPTASFNMSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.69|      75|     100|     581|     659|       3
---------------------------------------------------------------------------
  581-  659 (109.25/93.67)	LKLYQIKlGTLdELdAADTEWVYRPyMNTAAKRRFLSDEDGWQ...QEDEPEGRMSSYHLSTRERLLAI..VNDIEIVAKELIE
  683-  762 (108.43/73.73)	LKDKELK.STL.QL.AADQAGIEKK.MDSLREQVRKQDEEINQlqkQLKEAEQILATSIFQARQKLASIakANKRPVSSEDLIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     204.52|      41|     122|      89|     131|       4
---------------------------------------------------------------------------
   44-   76 (29.45/15.29)	..........................................................LASGS...FDK..TVAVFTLdrdRLNKE.NTYRGHTGSV
   77-  118 (56.12/37.78)	DQLCW..........................................HasmPD....lLSTAS...GDK..TVRIWDV...RVGKC.ATFINTKGEN
  119-  159 (48.84/35.03)	INITW..........................................S...PDGHT.......iavGNKedLVTFIDT...RTHKI.RAEEQFSFEV
  160-  243 (33.15/18.97)	NEIAWsngsdlffltngqgcvhilnypnlelqqilkahpstciciefD...PTG..ryFATGS...ADA..LVSLWDA...EELAClRVFSRLDWPV
  845-  874 (36.96/22.09)	NQFTW..........................................H...SSGEL.hMSMGA...GGG..SVSL.DT...RAHK............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.33|      18|      24|     777|     795|       6
---------------------------------------------------------------------------
  777-  795 (30.32/21.06)	LTWQQGDLRRPYPTDiEMR
  804-  821 (33.02/18.52)	LNINGHNLQHPSSLN.EMH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07789 with Med4 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NGHNLQHPSSLNEMHRNAAAAASGAAGGTGGEIPVPSQNQFTWHSSGELH
2) SMGAGGGSVSLDTRAHKDASQDDVEVMSTESSSSSSSDSQ
807
858
856
897










Molecular Recognition Features






MoRF SequenceStartStop




1) DTRAHKDASQDDVEVMSTESS
869
889