<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07787

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMKRVVWCILVFLTFAATSSKPNTKPVHPNAPESADISGFALEIILSRLETLQHDVERQRESIVENQTQLQQTHELLGKMRQDMQQKQSEAQKSIANIRGVLSEDVRQKLTNLERDHRQMRNALLDIQLVSGQYKIRANEVSLPFRAHCEQEQFDGGWLIIQHRFDGTLHFNRSWTDYRNGFGDVTGEHWLGLEKVYQFTKEHKCELVVQMMESNGTLQFARYNAFAIGSEAEGYNLIILGTYSGTADILAGHKGMKFSTPDRDNDPDDRHHYALENYGGWWFHNGQNPVEAPIENQIQEISYDGTETYQLPPTLSEHLAKCAAKIDFSKTSSDIDLLQQSIKKEDEKKEEESKDPKEQFQSSLWPWDSVRNKLKEALTEVCVLSDVLHIAKEKRFMVLDPIPQEPPEVKPMVLVYARKKALASAANILQSGVERLKAAQSDQGVNRSNSTDFHIELLRLRRNWRLKKVSNTIIGDLSYRTAGSKFMHPGMFEVTKAEDEESGSPPASPSGAGAAGTVACPKINSALRVNVPTELQGVAFIKVITQKDQEDLCTATLNMMGSTQLVPQAGAWQQTLEYAQNVLFCKELFNQLAREAVQLQAPIPHVVVGNQIRATLLPGIQLIISLCHSTSSDSNNSSEPIKDHDHVLEHSLHQLLREFHHKNTHHPFPHPASGPLGPSKKRMLAGPSAFDRHELLEMTKSQTLLEQIIAQAQHIFTRRRTQYVLDTLARDVKDPLITSHWNAMNSPTMSCVKINITSHGYDANLRTSLVIHVKERSLKCICRDGRIMHMSYEPQELRDLILCQISQHQIVCLQNLAKCMAWQILSSSSHLGIGAVEPLGNASSCVLASPNSDRLIAVQVRCDSQIDVKVYIAQSPAKDFFPGSLVQGRHWEHLGGHFKEVRFDKMEGKNFHNKMEFLMASLTSQS
Length925
PositionHead
OrganismAnopheles albimanus (New world malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.07
Grand average of hydropathy-0.443
Instability index50.60
Isoelectric point6.66
Molecular weight104328.41
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07787
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.40|      18|     152|     138|     155|       2
---------------------------------------------------------------------------
  138-  155 (33.17/22.18)	NEVSLPFRAHCEQEQFDG
  287-  304 (30.23/19.54)	NPVEAPIENQIQEISYDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.13|      20|      27|      54|      80|       5
---------------------------------------------------------------------------
   54-   76 (26.85/31.91)	DVERQREsivENQTQLQQTHELL
   82-  101 (31.27/15.07)	DMQQKQS...EAQKSIANIRGVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.49|      15|      46|     158|     172|       8
---------------------------------------------------------------------------
  158-  172 (29.08/18.69)	LIIQ.HRFDGTLHFNR
  206-  221 (21.41/11.89)	LVVQmMESNGTLQFAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.38|      18|     247|     551|     572|       9
---------------------------------------------------------------------------
  551-  568 (30.84/26.40)	LCTATLNMMGSTQLVPQA
  583-  600 (29.54/12.92)	FCKELFNQLAREAVQLQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.27|      44|     162|     671|     715|      10
---------------------------------------------------------------------------
  671-  715 (72.27/54.35)	ASGPLGPSKKRMLAGPSAfDRHELLEM.TKSQTLLEQIIAQ..AQHIF
  834-  880 (67.00/44.95)	AVEPLGNASSCVLASPNS.DRLIAVQVrCDSQIDVKVYIAQspAKDFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.94|      18|      29|     748|     775|      11
---------------------------------------------------------------------------
  748-  765 (32.41/34.63)	MSCV..KINITSHGYDA.NLR
  777-  797 (24.53/ 6.81)	LKCIcrDGRIMHMSYEPqELR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07787 with Med17 domain of Kingdom Metazoa
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