<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07784

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDNSWKTTNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFHKARNKDEYLGFVARLILHVREMNSKHKNQQNAAAAAAQQEGGNASQQGGGGGGMPDPINALQTLASQGTRPQMMGQMGPGGPMGGQMGGGNANPNMLHTPRLQMAMGGMAGMQGGNRVGMGPGPNQMGGMMPNQMQGPGPGAGMGGMAGQMGVIGPGGMSGGKIVGMGGQQQQQQQMAQLNAMQVNQMQAAQQVVQQQQQQQGGMPQQQGNMGQGPGVQQMGVVPGGPNQMNPMVMGQIQAQLQNQNAMGGQQMGAVGIGGGNPMGPLGGNTGMNPQAMGMGSNPVIRQQMVQQGVNPNQVQMGLSPAQMGQLGAGVQGGTGVPLQVQQAQAMQQQQQQQQQQQQGGGMGPNVGAGGPNQMNQVPMGPGPGGQMVGAQGNFVGMGGGNPMVRKPGDMMPGGNVYPGAGAAVRSVTPNNFLRQSPSPSVPSPLGPGAHGPQSHPGQMIPSPAIPSPNPMHGSVPQRSTIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYRSLTKYIEPLKRMIAKMENDDIDKIAKMKRLLEILCNPSVRIPLETLHKCEAALTSQLGSIRETPTNNPLVEAVSSSLQNATGNHTLQRTFRPCLEALFGPDIKNLPPPTKQPRLGTTSTGGQDDSNASVGTGSGTGSSVTGGTTGTGGTTTGASNNATSVGSSSVSNNQEIPHILQGEIARLDQKFKVSLDPCAITGSKTIKLICWLDDKSLPCVPPVAVTIPDDYPFTAPSCSLIEQEYNATPFLILVQRSFIARICKLPALFTLSHLLDTWEMSVRQACSPHPTLVAPTATSVLLGIDLVY
Length850
PositionTail
OrganismAnopheles albimanus (New world malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.452
Instability index49.00
Isoelectric point9.04
Molecular weight88300.41
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07784
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     279.38|      37|      37|     119|     155|       1
---------------------------------------------------------------------------
  119-  155 (81.27/22.22)	G....QMGPGGPMGGQ...MG...GGN......ANPNMLHTPRLQMA..........MGGMAG
  158-  193 (60.97/14.47)	GgnrvGMGPG.P..NQ...MG...G........MMPNQMQGPGPGAG..........MGGMAG
  196-  251 (42.72/ 7.50)	G....VIGPGGMSGGKivgMG...GQQqqqqqmAQLNAMQVNQMQAAqqvvqqqqqqQGGMPQ
  254-  285 (51.00/10.66)	G....NMGQ.GPGVQQ...MGvvpGG.........PNQMN.P...MV..........MGQIQA
  355-  382 (43.42/ 7.77)	G....QLG.AG........VQ...GGT......GVP..LQVQQAQ.A..........MQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     130.51|      23|      23|     466|     488|       2
---------------------------------------------------------------------------
  310-  335 (29.44/ 7.32)	GPlgGNTGmnPQ.AM.G...............MG.SNPVIRQQM
  439-  476 (32.72/ 9.23)	GD..MMPG..GN.VYPGagaavrsvtpnnflrQS.PSPSVPSPL
  477-  499 (38.56/12.64)	GP..GAHG..PQ.SHPG...............QMiPSPAIPSP.
  500-  524 (29.79/ 7.53)	NP...MHGsvPQrSTIG...............QS.PGGSLNTPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.82|      21|      23|     390|     410|       4
---------------------------------------------------------------------------
  289-  306 (28.64/ 7.19)	NQNAM....GGQQ....MGAVGIGGG...
  390-  405 (29.64/ 7.74)	.........GGGM....GPNVGAGGPNQM
  406-  434 (34.54/10.42)	NQVPMgpgpGGQMvgaqGNFVGMGGGNPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.60|      15|      23|     722|     743|       5
---------------------------------------------------------------------------
  725-  743 (19.32/32.94)	EIARLDQKfkvSLdPC....AIT
  750-  768 (26.28/12.98)	LICWLDDK...SL.PCvppvAVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.65|      19|     167|     626|     645|       6
---------------------------------------------------------------------------
  602-  620 (30.06/12.03)	SQLGSIRETPTNNPLVEAV
  626-  644 (33.59/19.04)	NATGNHTLQRTFRPCLEAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.16|      14|      15|     679|     692|       9
---------------------------------------------------------------------------
  679-  692 (25.04/12.02)	GSGTGSSVTGGTTG
  695-  708 (24.12/11.30)	GTTTGASNNATSVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.51|      14|      15|      87|     100|      10
---------------------------------------------------------------------------
   87-  100 (27.16/12.25)	NASQQGGGGGGMPD
  103-  116 (24.35/10.06)	NALQTLASQGTRPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.51|      16|      16|     553|     568|      11
---------------------------------------------------------------------------
  553-  568 (26.96/20.73)	IEPLKRMIAKMENDDI
  571-  586 (26.55/20.29)	IAKMKRLLEILCNPSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07784 with Med15 domain of Kingdom Metazoa
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