Description | Uncharacterized protein |
Sequence | MSSALLENSTGNNNKINWPITDGQELIDILETVYRGARKGRGLVREFHMMADRLTQLQDLVNELANLMCNSIGVLRLTAPSCDFNGTSKALEEEENCGLFAATIAHTAKDIEILIDSLPLDEPAASNSEIDSSLLNMDEQRHRAARELEQAVVDGEELIKKIQMALAEIARVQMLSRPFV |
Length | 180 |
Position | Middle |
Organism | Onchocerca ochengi (Filarial nematode worm) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.198 |
Instability index | 43.45 |
Isoelectric point | 4.66 |
Molecular weight | 19937.46 |
Publications | PubMed=22919073 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule U4/U6 x U5 tri-snRNP complex GO:0046540 IEA:InterPro |
GO - Biological Function | |
GO - Biological Process | mRNA splicing, via spliceosome GO:0000398 IEA:InterPro |
Binary Interactions |
Repeats | >MDP07771 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 79.45| 25| 130| 3| 27| 1 --------------------------------------------------------------------------- 3- 27 (44.19/34.72) SALL...ENSTGNNNKINWPITDGQELI 132- 159 (35.26/26.28) SSLLnmdEQRHRAARELEQAVVDGEELI --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 47.49| 15| 15| 43| 57| 2 --------------------------------------------------------------------------- 43- 57 (26.26/15.00) LVREF.HMMADRLTQL 60- 75 (21.23/11.13) LVNELaNLMCNSIGVL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) MSSALLE 2) NKINWPITDGQELIDILETVYR | 1 14 | 7 35 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab