<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07766
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MADRCSLKECLQESTEDLEATIKMIIAFVLDKDRSCGSLTSLCESFRKKHAELTKLLAKVPAYQQREREIRRLEAEVEARDKVLGDLQKQLMAAEKLITKMVFQADKKVKEMRQSEANRVNSETIIRFANQISRTYAVAAPLGWQLGDTSRPYPTEAELRLSALAAPRVIVQAAPPALSLLRQPTASTSGILRGSGRGASPMTSFSTAMQQQQRSWSPRSTFVQQSSSPRGRNAAGRGNIISPRINAAPGASLLQRRPSMTGSSPHLSSPSSSYQGSIREGLPPPVTNVEQMSSDSSSSSSSDEGSPS |
Length | 308 |
Position | Middle |
Organism | Onchocerca ochengi (Filarial nematode worm) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida>
Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.505 |
Instability index | 70.35 |
Isoelectric point | 9.75 |
Molecular weight | 33509.59 |
Publications | PubMed=22919073
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP07766
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 109.37| 28| 39| 176| 214| 1
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176- 201 (40.87/14.62) ......PALSLLRQPT........ASTSGILRGSGR.G..ASP
213- 243 (36.10/26.37) QR.swsPRSTFVQQ.S........SSPRG.RNAAGR.GniISP
244- 284 (32.40/ 7.34) RInaapGASLLQRRPSmtgssphlSSPSSSYQGSIReG..LPP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 59.85| 21| 39| 55| 76| 3
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55- 76 (29.50/28.36) KLLAKVpAYQ..QREREIRRLEAE
96- 118 (30.35/22.39) KLITKM.VFQadKKVKEMRQSEAN
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