<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07764

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMGDDDWPSQRFRDHVINRLEPELARNRQNAPNLPVPGDARQVEEYVFNKCVSKDEYMRTIAKVINAINCNSKSTTVPALLQPSRIQSASQNYRAAGLGVPPDPQPTQQQQQQQKVMDRYHTPLLGQPPPIIQSQQSSSGALSRTSMQPSQSNIQQHSPVTHPVVPQQTPYNMLSPIPSVPGSHSTSPNHQMYSLVKTEPKSGGSDGTNAAEVPISDSVSARVWKREDPSSGGYYPAGTYGATDSDQYVERGHSTASFMSRGTSIPSSQQQSISRHHQQLHQPSVLENLINSPHYGSPTPSSRHLNGSGNQNVADLPFGTTLQQSEERIYAEKLRSLRPYVESLRSRAQQCRLEGNEIAASKFDTMCNVLDGKSRVSFEYLLQIEAWIYKKQQFLQASLNAGTLQPQPLVDAVNAVLLNSETQVGYGDRVQANAGVPSAGQWPMSSGRSQQQQQQTSSQVLASMAPSSVPVAVCLARSTLMQSPMPLQTTSGQQVARHSVEHTYQRHSPYPNPNAGLRPGTQAQSMVLHHGSSRVQQAGAVATALPLFSESNRVPTADCSGVEDLYIMDDFLPTPIEAIPNSTSSQIEGQLPEAARQELLTFGDRFLADSNIEQISDSHSVVVKFSLTSHNVPPLQLIIPKTYPNGEVLVGRAALDLDSFFFDDLQNVIYERLARPGLRTVADFLETWESTVRGYYLGQQQQSLLPSSFDDILQNTNFDRILFFKISNFEGLEFLYTVILLNMERICFMLSC
Length751
PositionTail
OrganismOnchocerca ochengi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca.
Aromaticity0.07
Grand average of hydropathy-0.497
Instability index64.61
Isoelectric point6.03
Molecular weight82891.62
Publications
PubMed=22919073

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07764
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     200.08|      37|      44|      77|     113|       1
---------------------------------------------------------------------------
   77-  109 (51.34/18.81)	............P......AL..LQPSRIQSASQNYRAAGLGVPPDPQ.PT...QQQ
  110-  152 (49.68/18.01)	QQQQkvmdryhtP......LL..GQPPPIIQ.SQQSSSGALS.RTSMQ.PS...QSN
  380-  405 (26.07/ 6.57)	....................L..LQIEAWIYKKQQFLQASLNAGT.LQ.P.......
  406-  449 (28.68/ 7.84)	...Q........PlvdavnAV..LLNSETQVGYGDRVQANAGVPSAGQwPMssgRSQ
  450-  492 (44.31/15.40)	QQQQ....qtssQ......VLasMAPSSVPVAVCLARSTLMQSPMPLQ.TT...SGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     327.96|     126|     341|     153|     363|       2
---------------------------------------------------------------------------
  153-  188 ( 4.78/25.96)	........................................................................................................................IQQHSPvTHPVVPQ..QTPYNmLSPIP.SVPgshSTSPN
  217-  318 (138.07/120.84)	SVsARVWKREDPssggyYP...AGTYGATDSDQYVERgHSTASFMSRG...TSIP..SSQQQSISRHHQQLHQPSVLENLINSPHYGSPTPSSRHLNGSGNQNVAD..LPFG...............................................
  498-  644 (185.12/87.14)	SV.EHTYQRHSP.....YPnpnAGLRPGTQAQSMVLH.HGSSRVQQAGavaTALPlfSESNRVPTADCSGVEDLYIMDDFLPTPIEAIPNSTSSQIEGQLPEAARQelLTFGdrfladsnIEQISD.SHSVVVKfsLTSHN.VPPLQlIIP...KTYPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.16|      12|      46|     661|     672|       3
---------------------------------------------------------------------------
  661-  672 (22.89/17.58)	FDD.LQNVIYERL
  708-  720 (19.27/13.56)	FDDiLQNTNFDRI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07764 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MGDDDWPSQRFRDHVINRLEPELARNRQNAPNLPVPGDA
2) PMPLQTTSGQQVARHSVEHTYQRHSPYPNPNAGLRPGTQAQSMVLHHGSS
3) TVPALLQPSRIQSASQNYRAAGLGVPPDPQPTQQQQQQQKVMDRYHTPLLGQPPPIIQSQQSSSGALSRTSMQPSQSNIQQHSPVTHPVVPQQTPYNMLSPIPSVPGSHSTSPNHQMYSLVKTEPKSGGSDGTNAAEVPISDSVSARVWKREDPSSGGYYPAGTYGATDSDQYVERGHSTASFMSRGTSIPSSQQQSISRHHQQLHQPSVLENLINSPHYGSPTPSSRHLNGSGNQNVADLPF
1
483
75
39
532
317










Molecular Recognition Features






MoRF SequenceStartStop




NANANA