<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07761

Description Uncharacterized protein
SequenceMLVKNGQKYCGEHAICDELNEDRVVCPNDPKHTVNKSQLQKHLSSRCNSRLPEERWIVENFNLIGSPNEAEPWYHPTDKELLRMGKIVERIYDQIANDIADSFLKNNYVENYAADHSKLDKKHIWQISSIIEHLSVNDLLNNNKCWCLIDFGAGKAQLSYWMAKIAPKCRFLLVEKMGSRNKFDNKIHKEVDKIFLERLRCSVEHLDLSKIDLIQNANNVAAVCKHFCGSATDFGIRCLMNGVKNNLNICGFALAPCCHHRITYREYIGHAFLESHGICSSNEFAALRHISTWAVCGFLSQENFGGDVSVSSHSQELKNADQQKTVLEFVSLNSAEKELLGQKAKAVLEFGRIMELRKFGYDVSLCSGLNSVPGPETSEEQKKRFEIECEFVQALANPHYLNFLAQRGYFKEPFFINYLKYLLYWKRPEYARALKYPQCLHFLEAVQSSAFREAVTCTANAKFIEEQQLLQWQYYTRKRQRLHMYTTEHDDDEQEWRQQPSQRQKERELKFVEALEGTCKRMLQYKLHKEKSDISRFAKEESSTMKALNELRSKGVKVELGMPYEMWDSPSVEIVTLKQNCETLLEHYEDDLEQWYHIQDRPLLEEYLCKKRILKRTERGCMDTANNLEL
Length630
PositionMiddle
OrganismOnchocerca ochengi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca.
Aromaticity0.10
Grand average of hydropathy-0.566
Instability index46.76
Isoelectric point6.77
Molecular weight73470.00
Publications
PubMed=22919073

Function

Annotated function tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
metal ion binding	GO:0046872	IEA:UniProtKB-UniRule
transcription coregulator activity	GO:0003712	IEA:InterPro
tRNA 2'-O-methyltransferase activity	GO:0106050	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07761
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.17|      23|      39|     390|     412|       1
---------------------------------------------------------------------------
  390-  412 (42.13/23.95)	EFVQALANPHYLNFL..AQRGYFKE
  414-  430 (25.71/12.10)	FFINYL...KYLLYW..KRPEY...
  432-  453 (25.34/11.83)	...RALKYPQCLHFLeaVQSSAFRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     231.64|      85|      90|      31|     120|       2
---------------------------------------------------------------------------
   31-   82 (60.88/41.14)	.......................................KHTVNKSQLQKHLSsrCNSRLPEER.WIVENFNliGSPNEAEPWY...HPTDKELL
   83-  173 (131.67/79.08)	RMGKiVERIYDQIANDIADSFLKNNYVENYAADHSKLDkKHIWQISSIIEHLS..VNDLLNNNKcWCLIDFG..AGKAQLSYWMakiAPKCRFLL
  176-  212 (39.08/16.70)	KMGS.RNKFDNKIHKEVDKIFLERLRCSVEHLDLSKID.........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.44|      17|      20|     312|     329|       3
---------------------------------------------------------------------------
  320-  340 (21.53/15.94)	ADQQKTVLEFvslnSAEKELL
  341-  357 (27.91/15.99)	GQKAKAVLEF....GRIMELR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.11|      14|     238|       3|      16|       4
---------------------------------------------------------------------------
    3-   16 (28.89/14.57)	VKNGQKYCG.EHAIC
  243-  257 (21.22/ 9.09)	VKNNLNICGfALAPC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.13|      16|      39|     225|     241|       5
---------------------------------------------------------------------------
  225-  241 (27.98/25.24)	KHFCGSA..TDFGIrCLMN
  265-  282 (26.14/17.45)	REYIGHAflESHGI.CSSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.42|      27|     121|     457|     485|       6
---------------------------------------------------------------------------
  457-  485 (42.10/28.20)	CTANAKFIEEqQLLQWqYYTRKRQRLHMY
  581-  607 (51.33/26.20)	CETLLEHYED.DLEQW.YHIQDRPLLEEY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07761 with Med31 domain of Kingdom Metazoa
Unable to open file!