<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07755

Description Uncharacterized protein
SequenceMEEKDATTTDCRKTSSAQSGYRKRVMRRVNEDSHTQEPVASGTSNWLSGEERSRLEAVQRDWRLSRPAKPYSPWSRYRQLSIDKSSKSPGTIARKDTTAHQQTLFERNRIPAAPSLVISDTEGNKKKKIHETVNEEDEKEKIEENSAVILEIPLPLPSYESEKKDEELARTEEKQREVVDDDVDAEEEKPIDKSPDGRFLKFDEELGRGSFKTVYRGLDTETGVAVAWCELQESKLNKAERQRFREEAEMLKGLQHPNIVRFYDYWERQDHAGKKRYIVLVTELMTSGTLKMYLKRFKRINIKVLKSWCRQILKGLSFLHSRNPPVIHRDLKCDNIFITGTTGSVKIGDLGLATLKNKSYAKSVIGTPEFMAPEMYEEMYDESVDVYAFGMCLLEMVTGEYPYSECQFPAQIYRKVTTVSFSHRDMFINRDFTALGVKPECFSRIPQQYPEIREIIDRCIRVRREERSTVKQLLSDDFFTPEELIGIRVEIKNRDADLCDVNSEIQMQLRVFDEKKRKQYRFKENEGLQFAFDIETDKAEEVVQQMIEQQHIPEEDTRMITKLIKDKVEAFKRDREFRHAELKRLREEEQRKQEEEAIRNEMLLRAKEKERLEREAAAVLEQQQQSQQQAQQSQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSQQLQQQQQSAGASPENDDHHDGPVKHKKSKKKVAIEVLRVVTDETNQQPLVSCRLDTSHKTVTFQFAPDSDKPSVITKKLLDQDCLTNSQVGVVSEQLEKIIQMIVADPVKAVGVKIVSFVDSASTSANIEMTVSHSNVSANPVASSGVSGESNVMLAATSSMQNFQAVQPPVAPKNQSLDQTTVNSGVPQPAIAPSVAVSKSVVTTQNLPGIVQLPVSVVSHTASSNTTTTTGITTPVPAPAVTTSTTKTSRFLVTKSTLPVDISSSSTLPSLSSNLQEHIAKDAPSVVTAVSNSTSAPLINPVNTSSAVLQQTPNAELRTTLKKLESELCKVSGVNAPSNIPSVMNSGSVPPLDLPAISGGSLPCTSLPHTPSISSGLTHNLTGLNDKLLALSQKMQNEQMEEVVHHGNEAVASVAQTQHSPGITPGLHNASITPVVPTTLPNIVSGTVTPGKASATPEAGILHVDTLNELADALQKVIHFEPRETGSVPPPGVDITGHIAPLSIEHQSSSTTGVLHAGVTNLQDISSEVDRKAANDATKHASEDVKNIGSAGEGSGGENEKSEDGNYPGVASPTFTNNDEATANVHISATIPDGVGGSTANSAPLAKLENLETALTTTLGTHGYCPTVPHIINSTQPNCRTNNVANIDTQQAGLTQVSSLDAIHISQQSFNTMSEACETTQRSTSELAAMAAPKGAVFHVGTPPPPTHFSDSASQTELISTRDPLDHMFSPTTSYNSDYDFQERQRGRNLLVDEDKRIMLQLREILQLDEEYNEEDDDSIQSLIQRHRLELELLRERQRRELQLARLRLRHNQPGVGNTLVATGGGCLTRSIDSCGSGPHDPIHIPYHSLASSRINPHLKLPLSISLPGSPPQNSFLGQHLESLRDTLPRRSYMITSLAECARHTSVDAALSRRPAYPSTHCSSQINSNVADQHRHHQHHHHHYHHHHHQQQQQQQQQQQQQQGSISSSSLDHGYFHGGILSRQPVSTVIHRTSTITEVAPSLNYNIERQLRETFSTPPQ
Length1717
PositionTail
OrganismOnchocerca ochengi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca.
Aromaticity0.04
Grand average of hydropathy-0.710
Instability index62.18
Isoelectric point6.05
Molecular weight191372.14
Publications
PubMed=22919073

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
protein serine kinase activity	GO:0106310	IEA:UniProtKB-EC
protein threonine kinase activity	GO:0106311	IEA:UniProtKB-EC

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07755
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     177.74|      15|      15|     634|     648|       1
---------------------------------------------------------------------------
  631-  646 (34.26/12.74)	QQsQQQQQQQQQQQQQ
  647-  662 (34.26/12.74)	QQqQQQQQQQQQQQQQ
  663-  677 (38.66/15.11)	QQ.QQQQQQQQQQQQQ
  678-  692 (38.66/15.11)	QQ.QQQQQQQQQQQQQ
 1647- 1660 (31.89/11.46)	QQ.QQQQQQQQQQQQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.84|      21|      32|     801|     821|       2
---------------------------------------------------------------------------
  805-  838 (26.44/10.98)	KAVGVKIVSFVDSASTSaniemtvshsnvsANPV
  839-  867 (25.39/10.29)	ASSGVSGESNVMLAATS.....smqnfqavQPPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.30|      28|      32|    1094|    1125|       3
---------------------------------------------------------------------------
 1094- 1125 (44.08/31.83)	NE...QMEEVVHHGNEAVASVAqtqhSPGITPG..........LH
 1126- 1160 (32.37/14.34)	NA...SITPVVPTTLPNIVS.......GTVTPGkasatpeagiLH
 1165- 1195 (41.85/20.77)	NEladALQKVIHFEPRETGSVP....PPGVDIT..........GH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.27|      25|      32|      19|      50|       4
---------------------------------------------------------------------------
   23-   48 (40.55/49.47)	KRVMRRVNEDSHTQEPvASGTSNW.....LS
   52-   81 (40.72/20.73)	RSRLEAVQRDWRLSRP.AKPYSPWsryrqLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.80|      16|      31|    1380|    1408|       5
---------------------------------------------------------------------------
 1380- 1407 (23.22/38.78)	STSELaamaapkgavfhVGTPPPPTH.FS
 1411- 1427 (25.58/ 9.20)	SQTEL............ISTRDPLDHmFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      95.33|      18|      32|    1038|    1055|       6
---------------------------------------------------------------------------
  890-  908 (21.84/ 9.00)	PSVAVSKSVvTTQNLPGIV
  918-  935 (22.19/ 9.27)	TASSNTTTT.TGITTPVPA
  985-  997 (19.20/ 6.97)	TAVSNSTSA......PLIN
 1038- 1055 (32.10/16.88)	PSVMNSGSV.PPLDLPAIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.62|      26|      32|    1433|    1461|       8
---------------------------------------------------------------------------
 1433- 1459 (40.65/34.49)	NSDYDfQE..........RQRGRNLLVDEDKRIMLQL
 1466- 1501 (35.96/18.10)	DEEYN.EEdddsiqsliqRHRLELELLRERQRRELQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.90|      20|      32|    1298|    1328|      11
---------------------------------------------------------------------------
 1298- 1317 (31.54/48.11)	NSA.PLAKLENLETALTTTLG
 1330- 1350 (31.36/13.71)	NSTqPNCRTNNVANIDTQQAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.39|      19|      50|     121|     139|      12
---------------------------------------------------------------------------
  121-  139 (31.17/21.47)	TEGNKKKKIHETVNEEDEK
  171-  189 (30.23/20.58)	TEEKQREVVDDDVDAEEEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.96|      19|      50|     964|     982|      13
---------------------------------------------------------------------------
  964-  982 (30.08/18.24)	TLPSLSSNLQEHIAKDAPS
  998- 1016 (24.36/13.14)	PVNTSSAVLQQTPNAELRT
 1017- 1035 (27.53/15.96)	TLKKLESELCKVSGVNAPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.20|      32|      48|     365|     402|      14
---------------------------------------------------------------------------
  365-  402 (51.04/47.34)	IGTPEFMAPEMYEEMydesvDVYAFGM...ClLEMVTGEYP
  416-  450 (54.16/33.67)	VTTVSFSHRDMFINR.....DFTALGVkpeC.FSRIPQQYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.15|      18|      50|     226|     245|      15
---------------------------------------------------------------------------
  235-  267 (19.66/11.95)	KLNKAERQRFreeaemlkglqhpniVRFYDYWE
  268-  286 (22.49/ 7.64)	RQDHAGKKRY..............iVLVTELMT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      48.50|      10|      19|    1239|    1248|      23
---------------------------------------------------------------------------
 1239- 1248 (16.09/ 9.79)	SEDVKNIGSA
 1259- 1268 (16.96/10.79)	SEDGNYPGVA
 1269- 1278 (15.45/ 9.05)	SPTFTNNDEA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07755 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAMAAPKGAVFHVGTPPPPTHFSDSASQTELISTRDPLDHMFSPTTSYNSDYDF
2) ALQKVIHFEPRETGSVPPPGVDITGHIAPLSIEHQSSSTTGVLHAGVTNLQDISSEVDRKAANDATKHASEDVKNIGSAGEGSGGENEKSEDGNYPGVASPTFTNNDEATANVHISATIPDGVGGSTANSAPLAKLENLET
3) ESEKKDEELARTEEKQREVVDDDVDAEEEKPIDKS
4) KLLALSQKMQNEQMEEVVHHGNEAVASVAQTQHSPGITPGLHNASI
5) MEEKDATTTDCRKTSSAQSGYRKRVMRRVNEDSHTQEPVASGTSNWLSGEER
6) PWSRYRQLSIDKSSKSPGTIARKDTTAHQQTLFERNRIPAAPSLVISDTEGNKKKKIHETVNEEDEKEKIEENSA
7) QQLQQQQQSAGASPENDDHHDGPVKHKKSKKKV
8) REFRHAELKRLREEEQRKQEEEAIRNEMLLRAKEKERLEREAAAVLEQQQQSQQ
9) SRRPAYPSTHCSSQINSNVADQHRHHQHHHHHYHHHHHQQQQQQQQQQQQQQGSISSSSLDHGYFHG
10) VSHTASSNTTTTTGITTPVPAPAVTTSTTKTS
1385
1170
160
1084
1
73
695
575
1609
915
1438
1310
194
1129
52
147
727
628
1675
946










Molecular Recognition Features






MoRF SequenceStartStop




1) QSGYRKRVMRRVNE
2) SNWLSGEE
3) VQRDWRLSRPAKPYSPWSRYRQLSIDKSSKS
18
44
58
31
51
88