<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07754

Description Uncharacterized protein
SequenceMEKESIVERQEQKPVVDSTQSGNYNLVNFNLEEVEEEIRLEKIRQASVKFSWDYLSQLLRRNLMEKRFVLSADDKEDLMQAVADMRKHMPSDSDRDLSTHLRHLAESLSSDFQAHPGYYKIRNTDFSLEVTVSADGQQITSCSVSWFGERAMEAQALRLYISRNRWDLVHTALTAMFHLVPSDLSRDDKIYCLRSLEYAEKDLLNMSGSAPSIFEQINGDILGLCKPRTESTPFTIYPFVEPVIFFDTTSGSIVPPTDEQVLYDVEPYLQLCIVSNSTPNFFSDSTLFAHGEWRTAVSGRQLPAAFCLRFSRPIIFSSAAIKKLSKIALVQLDVEGSYNLYQYLLNENEECHDLFVRLPGCSTQHYIFDNSMMCSREDGILRQIPFAHLQDVVFLVNIIRTQLAHNAFFESLVRAHSRSACVDENIVDIRIASSYIDFFDLQFYLKKNLFIARVAVSPSNTNVSLECVINGAVLPESQHATAILTKSWSLAIMMRSVLRRGGAISLAALEKPFVMNENVDNNCDVKISQSWLFVPNITDSSINYNKIEHEYVVDERINLNYSHDNNTLGRQSPLSLLALFKELEKIEELIPPQKPMNGAQQCTAPPRNEMLAPRTSRIHSENTMTINAFSVLDAICDMAANIDDGESNVSEHSSHSSTNQRLRPQIPPQSPSPASERYRTSQAANFSQLSPLDIARQRLAQQAPMSNPTDVFEFDDPPRMTSASSMATSTQQFHFPEAGQSPYSFAAMQTTRGSLNVQPTLKRRGRGRKAGNVGDRMLDPTRPILDQNTGLIFRGMNIPTRKPRGTSTARRPRRPRKAAHMPVSPVHSHQFAINRPMLQRSFSEMPAYPSQMPSASLSQENRSEASEFDGTEESSDDETDPPPPACAATVPQPSAQFTARSSTPIAQTTTVTSLSSSSATLSLINKSSSLTATSCFPSTSSSGAATELTPPANSSPTSTNNGSVQSAALLAHKARKGSLEAVVGKLHCKTAPTSSSSSTTSNPYLASDLYDDESEPVSKPPEQPTPTKRDSPSVLTSSPGARMSPNLTKINAEQPGYGSELKIMIKLKQQAPTRPSIGPSQTSSGGVPSSMRLVGQPPSSSRSKEEKALLRQKQLKEKNRSASDERARKAGKRERKGEFNSSIKKLKLDRPLSEQKTMTISPKVEFPQALAFASLKNFKIPKVMENEKCESPTPTTTTAPAVATPSSSGAHLNVSQNSSSSTVQAVSSTSLSATLTTTPSSSSSSGTSSIFPPKPKSILKSSVDPPPPPLFRGMGGMPPMLPGRRPLLPDPRNVMHHPPRLEHILNQFRPLVTLPRMAPSVLGGGNFMPPPSSSGRWMALAPQRQPSPKNSPSEQSVSNSGLSDTAAAMSKMQDSPTETLKIVADEE
Length1387
PositionMiddle
OrganismOnchocerca ochengi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca.
Aromaticity0.06
Grand average of hydropathy-0.475
Instability index61.54
Isoelectric point8.26
Molecular weight152570.43
Publications
PubMed=22919073

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07754
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.02|      18|      18|     670|     687|       1
---------------------------------------------------------------------------
  654-  668 (20.00/ 7.86)	SHSSTNQRLR.PQIPP..
  670-  687 (31.44/17.74)	SPSPASERYRTSQAANFS
  690-  706 (26.57/13.53)	SPLDIA.RQRLAQQAPMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     504.10|      66|      66|     819|     884|       2
---------------------------------------------------------------------------
  746-  815 (52.55/15.34)	AAM.....QTTRG..SLNvQ..PTL..K.........R....RGRGRK....AgnVGD....................................RMldPTRPILDQN......TG..LI......FRGMNiptrkpRG.T...STAR......................R.P..RRP
  819-  884 (114.84/41.30)	AHMPVSPVHSHQF..AIN.R..PML..Q.........R....SFSEMP....A..YPS....................................QM..PSASLSQEN......RS..EA....SEFDGTE......ES.S...DDET......................D.P..PPP
  885-  952 (55.53/16.58)	ACAATVPQPSAQF..TAR.SstPIA..Q.........TttvtSLS............S....................................S....SATLSLIN......KS..SSltatSCFPSTS.......S.S...GAAT......................ElT..PPA
  953- 1021 (44.09/11.81)	NSSPTST..........N.N..GSV..QsaallahkaR....KGS.LE....A..VVG....................................KLhcKTAPTS..........S..SS....STTSNPY......LA.SdlyDDES......................E.PvsKPP
 1028- 1153 (46.76/12.93)	KRDSPSVLTSSPG..ARM.S..PNL..T.........K....INAEQP....G..YGSelkimiklkqqaptrpsigpsqtssggvpssmrlvgQP..PSSSRSKEE......KAllRQ....KQLKEKN......RS.A...SDERarkagkrerkgefnssikklklD.R..PLS
 1156- 1194 (47.44/13.21)	KTMTISP........KVE.....................................FPQ....................................AL..AFASL....................KNFKIPK......VM.E...NEKC......................E.S..PTP
 1210- 1268 (61.18/18.94)	AHLNVSQNSSSSTvqAV.........................SSTSLS....A..TLT....................................TT..PSSSSSS.........G..TS....SIFPPKP......KSiL...KSSV......................D.P..PPP
 1275- 1332 (48.84/13.79)	GGMP..................PMLpgR.........R....PLLPDPrnvmH..HPP....................................RL..EHI.LNQFRplvtlpRM..AP....SVLGG................GNF......................M.P..PPS
 1333- 1376 (32.88/ 7.14)	.....................................S....SGRWMA....L..APQ....................................RQ..PSPKNSPSE......QS.vSN....SGLSDTA......AA.M...SKMQ......................D.S..P..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     244.51|      84|     111|      70|     164|       4
---------------------------------------------------------------------------
   70-  164 (126.40/113.28)	LSADDKEDLMQAVADMRKHMpsdsdRDLSTHLRHLAESLSSDFQahpGYYKIR..NTDFSL....EVTVSADgqqITSCS.VSWFGERAM.EAQA.LRLYISRN
  184-  276 (118.12/78.97)	LSRDDKIYCLRSLEYAEKDL.....LNMSGSAPSIFEQINGDIL...GLCKPRteSTPFTIypfvEPVIFFD...TTSGSiVPPTDEQVLyDVEPyLQLCIVSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.22|      13|      94|     422|     435|       5
---------------------------------------------------------------------------
  422-  435 (17.80/15.23)	VDENiVDIRIASSY
  519-  531 (25.41/16.45)	VDNN.CDVKISQSW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07754 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ANIDDGESNVSEHSSHSSTNQRLRPQIPPQSPSPASERYRTSQAANFSQLSPLDIARQRLAQQAPMSNPTDVFEFDDPPRMTSASSMATSTQQFHFPEAGQSPYSFAAMQTTRGSLNVQPTLKRRGRGRKAGNVGDRMLDPTRPILDQNTGLIFRGMNIPTRKPRGTSTARRPRRPRKAAHMPVSPVHSHQFAINRPMLQRSFSEMPAYPSQMPSASLSQENRSEASEFDGTEESSDDETDPPPPACAATVPQPSAQFTARSSTPIAQTTTVTSL
2) AVVGKLHCKTAPTSSSSSTTSNPYLASDLYDDESEPVSKPPEQPTPTKRDSPSVLTSSPGARMSPNLTKINAEQPGYGSELKIMIKLKQQAPTRPSIGPSQTSSGGVPSSMRLVGQPPSSSRSKEEKALLRQKQLKEKNRSASDERARKAGKRERKGEFNSSIKKLKLDRPLSEQKTMTISPKVEF
3) IPPQKPMNGAQQCTAPPRNEMLAPRTSRIH
4) PKVMENEKCESPTPTTTTAPAVATPSSSGAHLNVSQNSSSSTVQAVSSTSLSATLTTTPSSSSSSGTSSIFPPKPKSILKSSVDPPPPPLFRGMGGMPPMLPGRRPLLPDPRNVMHHPPRLEHILNQFRP
5) SCFPSTSSSGAATELTPPANSSPTSTNNGSVQSAALLAHKARK
6) VTLPRMAPSVLGGGNFMPPPSSSGRWMALAPQRQPSPKNSPSEQSVSNSGLSDTAAAMSKMQDSPTETLKIVADEE
640
981
590
1181
934
1312
914
1166
619
1310
976
1387










Molecular Recognition Features






MoRF SequenceStartStop




1) EEKALLRQKQLKEK
2) ETLKIVAD
3) SIKKLKLDR
4) YGSELKIMIKLKQQA
1105
1378
1142
1057
1118
1385
1150
1071