<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07748

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDDEEYMKPMLPTVPEKCGPPVIPLGHLIEFAVQQIFHELTVLSELLPKKLDSDRKISIVQFAHSTRVLFIKLLAVVKWVKSSKKFESCASICYFLDQQSQYFVDTADRLVQLAREELVFARLPTFQVALAVDVLTAGTFPRLPLCIKNRFIPDPPITPREEACVLARLNQVIQYRLSSYGTKLSPRISKTVIRNGMVTMTVNGEFEVSLTLLGERPTTKWTLLNIRILVEDYEIGFGTKLVHPLQVNMLHNVLQLRMDKSLEPFQEVYSLLHSFAQMLQLDVLFCQATQVLSGDMCQYAVIERYTSQYRIKIFIDKENENNGLRVRHFPVGKGLPYIDDRSGRLSINRLLSETVGVRCRERLLRIRERLGLLKPPVIVSLTGRAAPTLTYPLLGAQSHVDEMLVLSINDFSGNVIAIVRALGPSLELRELEQLIDDRVPLQTITDKMGRLRILLMLERYRKAVAPLPVRIVPENVFCTRLSSLPELPPDRIYLQFIKEEMYYLIVSFTPNEQTGVNIDMYLLSNIERKLNMVRLHPSQLLTTLPESSFSNARNEDDLEPPAKRRRWLGDRRLLTSAVATLDDRLAFMRICEELDRRKVKYKPLTVEPTVGGLILHITDFSEAVPSGSDDFFSSVINCCLRLDTRTRVIWPFECTLINTPLVADFYEPIMCVDYESAKTKTTVMEIHGSGGVSSPNTSESVSTHMIDRLIVFAHMFDPVKEFAAAYYSHYNKYCNIVAFTYHKLVLAYGSNRNMLMMLSWRTQKAPNNKQYFYLTFGIGPNRPTTTVDLTNSETYNFHMLWNPHVLLASRLQERFNKRRSLIDLVQYLIDSVAPLFALHSFTRIRLQSLRAFCQMMCYDASLALSLQVTIAIVDEYRIRLIYGHMHLEFLLLGNSRIGLRDCSLGSACVFRLLQFCSNFLNSELRNMNEEKSPSAFGWTGSGSGPGSLPCHQMVRSPASRIVSSPMSHMSLSVPPIDSFGSSLRYSSDGRSKTPILLDHDSLLCMTSVDESGSCPLDQYLFALAYLSKLGPALEGYRREHRGSGAHPIIQFRQLITTPESVRLSVLGAAPPNLKHEPFLVNMNIYLDEETMSLKMKLDFDGEDIPADSDIRTAELYFIRFVARLGNEIAVVAFANACRLAAPGAFSAIARIMSMQMNWTEDTPWRPSIQLVMWSQEGSVPRARISPGIVIDQTNISVLILLCLRPARHNPSEKNADASKHLIPLIYNTQTNTVARRSSGADDDASNATTVLSNVSEQYSLTNEPALWPAIYSLAHNFAIQR
Length1281
PositionTail
OrganismOnchocerca ochengi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Onchocerca.
Aromaticity0.08
Grand average of hydropathy-0.049
Instability index45.53
Isoelectric point8.24
Molecular weight145077.38
Publications
PubMed=22919073

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07748
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     268.53|      84|     393|     723|     829|       1
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  736-  829 (132.71/144.63)	IVAFTYHKLVLAYGS....NRNMLMMLSWR..TQKAPNNKQYFYLTFGIGPN...RPTTTVDLTNsetynFHMLwnphVLLASRlQERFNKRRSLIDLVQYLI
 1130- 1222 (135.81/89.27)	VVAFANACRLAAPGAfsaiARIMSMQMNWTedTPWRPSIQLVMWSQEGSVPRariSPGIVIDQTN.....ISVL....ILLCLR.PARHNPSEKNADASKHLI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.45|      36|     356|     101|     184|       2
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  144-  184 (61.09/120.25)	PLCIKNRFIPDP......PITPREEACVlarlnQVIQYRLSSYGTKL
  489-  530 (57.36/21.34)	PDRIYLQFIKEEmyylivSFTPNEQTGV.....NIDMYLLSNIERKL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.31|      10|     356|      14|      23|       3
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   14-   23 (21.69/13.50)	VPEKCG...PPVI
  366-  378 (14.62/ 6.40)	IRERLGllkPPVI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.70|      14|      15|     111|     124|       4
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  111-  124 (22.90/13.86)	VQLAREELVFARLP
  128-  141 (22.81/13.77)	VALAVDVLTAGTFP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.01|      46|     605|     380|     454|       6
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  400-  454 (70.54/74.12)	VDEmlvlsindfSGN........VIAIVRALGPSLELRELEQLIDDRVPL....QTITDKMG.RLRIL
 1008- 1066 (63.47/24.89)	VDE.........SGScpldqylfALAYLSKLGPALEGYRREHRGSGAHPIiqfrQLITTPESvRLSVL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.50|      60|     564|     272|     351|       7
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  272-  351 (83.89/106.49)	LHSFAQmLQLDVL..FCQ.....ATQVLSGDMcQYAVIErytsQYRIKI........FIDKENENNGLRvrhfpvgkglpyidDRS.GRLSINRLL
  838-  913 (84.61/56.55)	LHSFTR.IRLQSLraFCQmmcydASLALSLQV.TIAIVD....EYRIRLiyghmhleFLLLGNSRIGLR..............DCSlGSACVFRLL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.79|      25|     220|     229|     258|       8
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  229-  258 (38.54/32.27)	LVEDYeigfgTKLVHPLQVNML.HNVLQLRM
  456-  481 (40.26/22.04)	MLERY.....RKAVAPLPVRIVpENVFCTRL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07748 with Med14 domain of Kingdom Metazoa
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