<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07742

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGFVRLTQACVAGGVDPAGWLAESRGMVSSTGLLQLILATRPPSARLLAYYQAAIAAAAIDPAEAASQLIHASQPLRAALARPLRTATLIPAGPEHASQLLATLLQLTATPDTRPLAEQLLTALAPTILSHPPTPPRHPKPSTNSPPSSTPPTTTTTTTTTTTTISTPSSATSLPPPPNNAPPTTTTTTTTTQPPPAHSSPTSSSPPAQPHPPTPSSPHPSPHTHMQTPTHPSKTSSTPPSASPTPATPATPTKTPTDASGPPSSPAAASPSSSAPPSPPTQNSAPPTSSASNSPSTTPASGPPSTPPSSPTASPKPFPIPPPPGTSTSGSSRCSTRSARTSRPRPQPWHASSTSFLFQTLETAAATFDLATCMALTTALSTLGGLGVLFLWLEPRALLAPVRGLLDHWLARRASSAQGPPPPRPTTTRPAAAASSRASAPSSAGCRASWAGLTPSTAYATSELPATHESVMRVWIEALYGSSGIPDALLGSTDPRIFFATAATIVKQSFDALAVGRIDLQTFRDGLSYFEHKLLIGGAAVGVVGWILDELTRLGPFSPTDYPTALLEILQAILLSDAISPTALRLVGARSLGVIRAYDGRVSSPTAVLLPPDDAGLGRRVQLDVAGLEQRLTELPASEMEDPAGFLAHDFGPGTGWPTALTMAPHSHGRPTVRVQKAWDAARYHRVHRAVSVAVDVLTWPAPPARGPAPLPVALLDQLFGRWGDRLAAPAGTLEDALVERDIVLACLARLDAWASSHPSPPASEDEPGNPVAPIDAARFREMCVTSLRAQKLGPAPPRPRRGARDGLGGACDGTAVAKEEGPRRESRPGLSVGDGVIGQADGEAEAEGRVPEGREGPGAAGLFDTEAPSGRRDEEMPPETDDGQGAASDTVGRPDDPATTREEAAEIGAAAAMDVDCEPCPAPAAPAKKVHFLADRSPAAAAHPAGHGGRKRRKTAAGLDWICAGLAFAPLRHPPPVDGALSFLDVLERADERFVLVGLRDG
Length1004
PositionTail
OrganismPuccinia triticina (isolate 1-1 / race 1 (BBBD)) (Brown leaf rust fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.04
Grand average of hydropathy-0.252
Instability index60.09
Isoelectric point6.40
Molecular weight103570.25
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364142

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07742
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     159.59|      28|      28|     147|     174|       1
---------------------------------------------------------------------------
  151-  181 (43.94/11.97)	TP.PTTTTTTTTTTTTISTPSSATSlppPPNN
  182-  210 (40.84/10.37)	AP.PTTTTTTTTTQPP.PAHSSPTS.ssPPAQ
  244-  275 (36.51/ 8.12)	SPtPATPATPTKTPTDASGPPSSPAaasPSSS
  295-  318 (38.31/ 9.05)	SP.STTPASGPPSTP....PSSPTA...SPKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     496.37|      93|      93|     595|     687|       2
---------------------------------------------------------------------------
    6-  101 (75.50/18.23)	...............RL...TQACVA....GGVDPAGWLAE.......SRGMVSSTGLLQLILATRPPSARLLAYYQAA...................................................iAAAAID......PAeaasqlihasqplraalarplrtatliPAGPEHASQL
  396-  433 (46.02/ 8.23)	P.RALLA................PVR....GLLD..HWLAR........R..........ASSAQGPPPPRPTTTRPAA.......................................................................................................
  582-  624 (53.43/10.75)	......................................................PTAL............RLV....GARSLG.........................VIRAYDG..........RV..S.SPTAVLL...P.PD...........................DAGLGRRVQL
  625-  712 (150.73/43.74)	D.VAGLEQ.......RL...TELPAS....EMEDPAGFLAHD.....FGPGTGWPTALTMAPHSHGRPTVRVQKAWDAARYHR.........................VHRA..............V..S.VAVDVLT...W.PA...........................PPARG.PAPL
  713-  842 (88.91/22.78)	P.VALLDQlfgrwgdRL...AA.PAG....TLED..ALVERDivlacLARLDAWASSHPSPPASEDEPGNPVAPI.DAARFREmcvtslraqklgpapprprrgardgLGGACDGtavakeegprRE..S.RPG...L...S.VG...........................DGVIG...QA
  843-  934 (81.78/20.36)	DgEAEAEG.......RVpegREGPGAaglfDTEAPSGRRDEE.....MPPET..DDGQGAASDTVGRPDDPATTREEAA................................................eiG.AAAAMDVdcePcPA...........................PAAPAKKVHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.23|      12|      23|     320|     332|       6
---------------------------------------------------------------------------
  320-  332 (22.23/ 9.72)	PIPPPPGTStSGS
  345-  356 (24.99/ 7.82)	PRPQPWHAS.STS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.39|      12|      23|     488|     499|       9
---------------------------------------------------------------------------
  488-  499 (22.25/10.94)	DAL.LGSTDPRIF
  512-  524 (17.14/ 6.91)	DALaVGRIDLQTF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07742 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLATLLQLTATPDTRPLAEQLLTALAPTILSHPPTPPRHPKPSTNSPPSSTPPTTTTTTTTTTTTISTPSSATSLPPPPNNAPPTTTTTTTTTQPPPAHSSPTSSSPPAQPHPPTPSSPHPSPHTHMQTPTHPSKTSSTPPSASPTPATPATPTKTPTDASGPPSSPAAASPSSSAPPSPPTQNSAPPTSSASNSPSTTPASGPPSTPPSSPTASPKPFPIPPPPGTSTSGSSRCSTRSARTSRPRPQPWHASSTSF
2) TSLRAQKLGPAPPRPRRGARDGLGGACDGTAVAKEEGPRRESRPGLSVGDGVIGQADGEAEAEGRVPEGREGPGAAGLFDTEAPSGRRDEEMPPETDDGQGAASDTVGRPDDPATTREEAAEIGAAAAMDVDCEPCPAPAAPAKKVHFLADRSPAAAAHPAGHGGRKRRK
101
787
357
956










Molecular Recognition Features






MoRF SequenceStartStop




1) KVHFLADR
931
938