<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07739

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSPSSPNQNNNHFNNSNSSNSSSNNNNNRFYQQQQQQHFYQQQQQLHQHQQQQQHHQQQQHQHHQQFLFQQQQNYHRQQLSHQHHHHHHHLYQQNTYPQPLIHHRQLQKSPAAFLRTQQQQQHQHQQHQQHQQHQPISPLPLIPPPPPPPNSFPLPIIPPNSNSINSNNQRNHHQQQQQQQQHHHRFNNHRDSNRRNYRQPSFRTNLSLPHHPSLPKPPTAERTPTIPLTPIHHHSPTAATSPSFSKPINTNPPPPPPPPTTAPASSSRHLHSPSTSTLQSSLAPDDHLLGLAGPHSAAFVPPAAFDLAPWRGCAPSKWKVALLHSAPPAEDPPRCARDLLAIDEPADEILLPGPAPPQEEEEEWKIRWAKIRLRPHDDQDGPPDRASLAKQLHALKLHFVFDDEHHHQQPQSALLWIYEIPGRLASKRNFVPPPPLIDPALKTYLDYQHGTVAGPIVACRSVISYGVLSYSQLFPNLFTRSPTTTSKPLLPHLSHPAKSRTGNDFLADDSSQTSTIPAYTHLLQALSQHVISLAVRSPDSTPFAGASPARWLRWGRDRLLSVPREDSLEFLYRNLSHPHPPRLIGAILTAAPALVVDLKCWLSARSAMCQPSFTPIRLAPMPPLPQNNLPPGFPLILAPFPTLRARFVRILGRFNHHSLARFTQAPAAHSPSFPRNPTPPNPSWISQQKRICRAELKRIEKLKQTWRAAAPFMDPHPDHPAPRGCESWVVCKITSGAAGPETGESSPEIELVWPADHCLLDLESWMATAEEPAMSPSEPAQPAPAPPETRASGPCLPRASLATALMLSTYEPIDQLAEDAGVYIDWVAQERELQRRAAAAATGPAGKEKTPQKTESPPSITAGRAGLGPANRGRANGYPSPRFLRHSSSCSTARASPVPPHRINHRPSKKRLRDDSDDRSSSLLSSSAPLLSTPLDGGLAGPANTSTLEDRLAPNHHASEMDVYGSAANLPDPLFSQSQAFPRSTVVKDTNSATQQSTNPIPAPISSQFVSAQHAPGTGSTASTVSCNTNLFEQPTPGSLSISGLTPGRLNGFTPDAAHNTNTRPSNPNAHLTSADAAPVDPLAVSEHALRSLSLISAASDSAPLYRVVEPVGYESVRFSHSHTVVDDHYTRRGGKFALPASPRSFTGPSEDELEEMLDLGDHQEILRVARGPLLVQVSKKLTRAIDPRAKVARTLFNITTTSSSIIRTNDHPFGRGEALTTSSIAANTTQGATSGYAESPATPRSWVPIGSSNESSDGSSFSEDDEEEPDGPDFGRDIDGRSGSESASTSSWPSDDERMVALERQFCDSVAAKIELTESNLKDVLECHYRATFFEPNGRADGRADDRTPRPQDIPPSVKKKMKHWVSQLASQLEHDPHLEVLLHTILPSSSKTAAGRDEGLGTHKRVVLDVASLPVIRGVECYRARVDDEHEIQENRSADHHQKEGGAEKKSNKQKTKVKGAEADHQRPYLVQRSPASPPAVVLKINEGKHKIAFSLLSQLFKFWIKLGFEPVAGHRDTVLSVIFPTPLSPNRSDQHAQVENVCPSQLGQAESRAFHLSSVHHWLLELAHTYKSCRLGELTIGKIHESKYRSGELKKEIEGMIGAMDGDKTCRHTCLIVVDRLEEMKSLGVGEREIVGLDGRPVTRLLVSRHQLLDDRPASLGARAKLRPTSRIRPFSAGLGGRRLEQRHGRPEGEPRDNRRGEGGTAPPEQASLGPQAALRPRLLPRRHPAPHPQLNIRWPPSGIDVAARHRILHTAYLVGPGRAWVLVSSVDELGQQHQLRLKFPPPSDNTPLGSELDVERRLEIQVVQAVWDVVRSIILSTDVEWRVVITKLGRIQPPEYEAWCELLSQTLPASEVAFHVTLASVLLGEVPVLRRVPSESMASSPATGEGGGGGAEGGGGSDLEMGERSINATIVHALSSSYIYHARSSATTSGLRAPTPGPSVAAFTLDILGTAASSSSVYTASLLALRDDIIVSLARLAHLKHLRHGLPSASSSVAAVVEGTQADLRLLPSHLSSLASIGASLAAHFATLAALLAPSPASAPGPSGPHDSQDAPDAERGTDVDGDILLDDPGCLR
Length2082
PositionKinase
OrganismPuccinia triticina (isolate 1-1 / race 1 (BBBD)) (Brown leaf rust fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.05
Grand average of hydropathy-0.580
Instability index59.20
Isoelectric point8.04
Molecular weight227746.35
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
chromatin binding	GO:0003682	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
cell cycle	GO:0007049	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07739
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      86.73|      13|      19|      47|      59|       1
---------------------------------------------------------------------------
   33-   49 (19.14/ 6.28)	QQQQQHfYQQQ.qqlHQH
   50-   66 (24.05/ 9.82)	QQQQQH.HQQQqhqhHQQ
   70-   84 (23.35/ 9.31)	QQQQNY.HRQQ..lsHQH
  168-  178 (20.20/ 7.05)	NNQRNH.HQQQ......Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.84|      25|      38|      86|     114|       2
---------------------------------------------------------------------------
   86-  105 (36.45/ 8.72)	............HHHHHLYQQNTYPQPLIHHR
  110-  137 (27.75/ 8.40)	SPAAFlrtqqqqQHQHQQHQQHQQHQP.I...
  138-  161 (42.65/ 9.73)	SPLPL.......IPPPP.PPPNSFPLPIIPPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     417.37|      72|      73|     859|     930|       3
---------------------------------------------------------------------------
  218-  285 (68.51/24.45)	..........PPTAERTPTI....PlT.P......I..HHH.S..PTAA...T.........SPSFSKPINTNPpppppppttapasSSRHLHSPS...TSTLQSSLAP......
  734-  795 (61.21/20.93)	ITSGA.AG..PETGESSPEIelvwP.A.D...HcLL..DLE.SWMATAEepaM.........SPSEPAQPAPAP.............PETRASGP....................
  861-  935 (113.01/45.97)	ITAGR.AGLGPANRGRANGY....P.S.P...R.FL..RHS.SSCSTAR...A.........SPVPPHRINHRP.............SKKRLRDDSDDRSSSLLSSSAPllstP.
  936-  984 (65.58/23.04)	LDGGL.A..GPAN.............................TSTLEDR...L.........AP......NHHA.............SEMDVYGSAANLPDPLFSQSQ...afPR
  985- 1045 (36.09/ 8.78)	STVVK..DTNSATQQSTNPI....P.A.PissQ.FVsaQHApGTGSTAS...TvscntnlfeQPTPGS..........................................lsiSG
 1046- 1105 (72.98/26.61)	LTPGRlNGFTPDAAHNTNTR....P.SnP...........N.AHLTSAD...A.........APVDPLAV.................SEHALRSLS...LISAASDSAP......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.84|      17|      59|     605|     626|       4
---------------------------------------------------------------------------
  607-  626 (24.06/19.22)	SAMCQPSFtPiRlAPMPPLP
  667-  683 (33.78/ 9.48)	PAAHSPSF.P.R.NPTPPNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.50|      12|     355|     203|     215|       5
---------------------------------------------------------------------------
  203-  215 (21.09/15.60)	FRtNLSLPHHPSL
  573-  584 (26.41/14.86)	YR.NLSHPHPPRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.13|      38|     355|    1337|    1405|       6
---------------------------------------------------------------------------
  354-  413 (55.90/17.94)	GPA.......PPQEeeeewkirwakirlrphddQDGPPdraSLAKQL.HAL.KLHFVFD.DEH.....HHQQPQS
 1340- 1392 (47.23/74.84)	GRAdgraddrTPRP...................QDIPP...SVKKKMkHWVsQLASQLEhDPHlevllHTILPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.04|      14|      49|    1632|    1645|       7
---------------------------------------------------------------------------
 1632- 1645 (25.82/15.14)	GVGEREIVGLDGRP
 1682- 1695 (27.22/16.42)	GLGGRRLEQRHGRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.23|      28|      28|    1240|    1267|       8
---------------------------------------------------------------------------
 1240- 1267 (52.89/23.96)	ESPATPRSWVPI.G.SSNESSDGSSFSEDD
 1269- 1298 (45.34/19.51)	EEPDGPDFGRDIdGrSGSESASTSSWPSDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.66|      19|      59|    1717|    1735|       9
---------------------------------------------------------------------------
 1717- 1735 (35.40/16.54)	LGPQAALRPRLLPRRHPAP
 1778- 1796 (35.27/16.45)	LGQQHQLRLKFPPPSDNTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     357.03|     101|     103|    1847|    1948|      11
---------------------------------------------------------------------------
 1798- 1889 (105.17/51.72)	...............GSELDV.ERRLEIQVVQAvwdVVRSIILSTdvewRVVITKLGRIQP.......PEyeAWC.ELL....SQTLPASEVAFHVTLASVLLGEVPV.LRRVPSESMASS
 1890- 1993 (144.75/78.24)	PATGEGGGGGAEgGGGSDLEMGERSINATIVHA...LSSSYIYHA....RSSATTSGLRAPT....PGPSvaAFTlDIL....GTAASSSSVYTASLLA..LRDDIIVsLARLAHLKHLRH
 1996- 2082 (107.11/53.04)	PSASSSVAAVVE.GTQADLRLLPSHLSS..LAS...IGASLAAH.......FATLAALLAPSpasaPGPS.........gphdSQDAPDAERGTDVD.GDILLDDPGC.LR..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.59|      14|      49|     289|     302|      13
---------------------------------------------------------------------------
  289-  302 (26.10/10.90)	LLGLAGPHSAAFVP
  340-  353 (21.49/ 7.70)	LLAIDEPADEILLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.95|      20|     389|     311|     336|      17
---------------------------------------------------------------------------
  311-  336 (36.52/30.40)	WRGCAPskwkvaLLHSAPPAEDPPRC
  707-  726 (43.43/22.30)	WRAAAP......FMDPHPDHPAPRGC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.98|      50|     303|    1115|    1174|      19
---------------------------------------------------------------------------
 1115- 1174 (74.22/73.84)	YESvRFSHSHTVVD....DHYTRRGGkfalpASPRSFTGPSEDELEEmldlGDHQEILRVARGP
 1425- 1478 (82.76/54.10)	YRA.RVDDEHEIQEnrsaDHHQKEGG.....AEKKSNKQKTKVKGAE....ADHQRPYLVQRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.69|      12|      15|       2|      13|      21
---------------------------------------------------------------------------
    2-   13 (25.90/16.87)	SPSSPNQNNNHF
   19-   30 (23.79/14.77)	SNSSSNNNNNRF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07739 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDEHEIQENRSADHHQKEGGAEKKSNKQKTKVKGAEADHQRPYLVQR
2) IRTNDHPFGRGEALTTSSIAANTTQGATSGYAESPATPRSWVPIGSSNESSDGSSFSEDDEEEPDGPDFGRDIDGRSGSESASTSSWPSDDERM
3) LQRRAAAAATGPAGKEKTPQKTESPPSITAGRAGLGPANRGRANGYPSPRFLRHSSSCSTARASPVPPHRINHRPSKKRLRDDSDDRSSSLLSSSAPLLSTPLDGGLAGPANTSTLEDRLAPNHHASEMDVYGSAANLPDPLFSQSQAFPRSTVVKDTNSATQQSTNPIPAPISSQFVSAQHAPGTGSTASTVSCNTNLFE
4) MSPSSPNQNNNHFNNSNSSNSSSNNNNNRFYQQQQQQHFYQQQQQLHQHQQQQQHHQQQQHQHHQQFLFQQQQNYHRQQLSHQHHHHHHHLYQQNTYPQPLIHHRQLQKSPAAFLRTQQQQQHQHQQHQQHQQHQPISPLPLIPPPPPPPNSFPLPIIPPNSNSINSNNQRNHHQQQQQQQQHHHRFNNHRDSNRRNYRQPSFRTNLSLPHHPSLPKPPTAERTPTIPLTPIHHHSPTAATSPSFSKPINTNPPPPPPPPTTAPASSSRHLHSPSTSTLQSSLAPDDHLLGLAGPH
5) PFSAGLGGRRLEQRHGRPEGEPRDNRRGEGGTAPPEQASLGPQAALRPRLLPRR
6) PNGRADGRADDRTPRPQDIPPSVKKKMKHWVSQLA
7) SWMATAEEPAMSPSEPAQPAPAPPETRASGPCLPR
8) TPGSLSISGLTPGRLNGFTPDAAHNTNTRPSNPNAHLTSADAAPVD
1430
1208
834
1
1678
1338
765
1037
1476
1301
1034
296
1731
1372
799
1082










Molecular Recognition Features






MoRF SequenceStartStop




1) EEEWKIRWAKIRLR
362
375