<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07731
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MESQLLTPLSTLETRLNNLLMSIVSSPTAAGAPAAALSLLEADDALSCALKTLHTHQLNYAKILRLRAEALTLEERVRDIVREVENVGNEISTACQEGVGASDDDSSVSDVKIEADGEKEKEGEDVDTQMGGVSAGSPVGLKRAGNRRGKEIKEIDYKLLVNFARRISRYNSDAAADVSASSPIKATPPLGDTDGQGQQTNVIEENGGDAERVGAGGQQGGKGFGVAALSQETVSWLDETANWSRDLSRMAFPSEERIRMGLMGQLQAKANEGVDVEKEIELLIRTSEGVGVDGGGEASAAAGGQGTLMDEVVGIEGEQIGHGRASGGISRADTAVGGVPAPRPKPKAVLDLDLYDPDEDD |
Length | 361 |
Position | Middle |
Organism | Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
|
Aromaticity | 0.02 |
Grand average of hydropathy | -0.401 |
Instability index | 40.11 |
Isoelectric point | 4.52 |
Molecular weight | 37836.45 |
Publications | PubMed=26439490
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP07731
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 281.38| 78| 84| 136| 218| 1
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78- 133 (54.82/24.20) .............................RDIVR..EVENVGNEISTA....CQEGVG.ASDDDSS....VSDVKIEADGEKEKEGedvdtqMGGV
136- 218 (119.08/72.68) GSPVGLKRAGNRRGKEIKEIdykllVNFARRISR..YNSDAAADVSASSPIKATPPLG.DTDGQGQ....QTNVIEENGGDAERVG......AGGQ
221- 305 (107.48/56.72) GKGFGVAALSQETVSWLDET.....ANWSRDLSRmaFPSEERIRMGLMGQLQAKANEGvDVEKEIEllirTSEGVGVDGGGEASAA......AGGQ
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