<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07730
Description |
Mediator of RNA polymerase II transcription subunit 20 |
Sequence | MPVTGLYFIPASQNSPTATGTVIERLRSAYNPTLCGRWALEHKLLRDTPSCLPPSDYAPLPPLQPRFMQFLSLSHRQPYGFIYISDRPNPDPWDSRSLGATHVGRVQPQPQPQQPKQQQQQQQQQQQQQQQQQQQQQQQQQQQENPPLHTPDPPSAAGKTMMILDYPSYISFHAITLRACEPLWCPRHTITVPNGNHFEIGDFRIRIGDVRQTAPQTRMRGTIVEIEYRGPAGAGDVAASAAAAAAAAAGADTHPMTDGGETWPPSITDGNIGLGGGPGDEDGILYPQLETLSPSPSSSSALVEDIPTDEDWEVGEVLIRELWSRFAVEGAREVIRVPHLGKEAREARRLGKLGDRAVNARIAGADLARQYMEVFRFNR |
Length | 379 |
Position | Head |
Organism | Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.637 |
Instability index | 62.82 |
Isoelectric point | 5.87 |
Molecular weight | 41940.45 |
Publications | PubMed=26439490
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364152
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP07730
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 63.64| 15| 15| 113| 127| 1
---------------------------------------------------------------------------
113- 127 (31.97/12.08) QQPKQQQQQQQQQQQ
129- 143 (31.68/11.92) QQQQQQQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 81.24| 22| 27| 261| 282| 2
---------------------------------------------------------------------------
261- 282 (43.24/27.63) ETWPPSITDGNIGLGGGPGDED
290- 311 (38.00/23.36) ETLSPSPSSSSALVEDIPTDED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 119.69| 37| 142| 183| 221| 3
---------------------------------------------------------------------------
183- 221 (62.70/50.06) LWC......PRHTITVPNGNHfEIGDFRiRIGDVRQTAPQTRMRG
322- 364 (56.99/36.10) LWSrfavegAREVIRVPHLGK.EAREAR.RLGKLGDRAVNARIAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 75.37| 22| 27| 44| 68| 4
---------------------------------------------------------------------------
44- 66 (39.71/20.89) LLRDTP.SCLPPSDYaPLP.PLQPR
73- 96 (35.66/10.78) LSHRQPyGFIYISDR.PNPdPWDSR
---------------------------------------------------------------------------
|