<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07728
Description |
Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MAAQSAVPLEEITWRSPLHVQTMGGFLHSNNILFYFAESPFFDQTSNNASLAIQANYNENFRPFIETREAFEGRLKTMQGLEFMVVHDPLQEAAAAAAVGGKQQRKQQELSNIWVIRKQMRKKRTGVGSGAAGGDDEIQVLATYFVVGDSVFMAPSVLRVVGSRMLSAVTSLTRALSVASPLPTFSPSYGHTYMPPVPKSLEASRPGVQQSGQQSVGDAPMPDASSQSKGGSVLSATGTTQQPTASTSPLASSSTTTQDSRSLVEAFNLLSRYGDEYMDDAPLLGEPGSFIIGKTSTEPLVVGMRQPMSSKVSKAPTPAPSAGAGPGASKPWTPAATGGAAAPPAIKTDAATLGAGKAGRGGEKSPTTPGGGKERVKRRKSKVSSATVASLAAGSSAGGS |
Length | 400 |
Position | Head |
Organism | Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.281 |
Instability index | 59.17 |
Isoelectric point | 9.56 |
Molecular weight | 41509.24 |
Publications | PubMed=26439490
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP07728
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 111.40| 28| 30| 298| 325| 1
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298- 325 (50.92/22.03) EPLVVGMRQPMS...SKVSKAP....TPAPSAGAG
330- 356 (33.79/12.49) KPWT.....PAA...TGGAAAPpaikTDAATLGAG
368- 394 (26.68/ 8.54) TP..GGGKERVKrrkSKVSSAT....VASLAAG..
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 163.73| 54| 54| 171| 224| 2
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116- 187 (44.10/19.50) .........IRKQMRKKRTGV.GSGAAGgddeiqvlatyfvVGDSVfMAPSvlrvvgsrmlsavtSLTRALSVAS.......PLPTFSP
188- 249 (89.49/47.22) SYGHTYMPPVPKSLEASRPGVQQSGQQS.............VGDAP.MPDA.............sSQSKGGSVLSatgttqqPTASTSP
272- 296 (30.15/10.99) RYGDEYMDDAPLLGE...PGSFIIGKTS.............................................................
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