<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07725

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPMIMEDSIDVDDLFGDPTSLELGLEGAAPTIKGLPQRLDELRLSGCSQKIAWSKLGAIAYVSQDGQKVLLRYLHCRPDDGKWTLSEESPINQIVDIHGGHTVVHLLWNESGSELAIVDSCGRIAIVTIMMSLNTVNQPRQASIDPDDDLAQPVGLMWLNLNRPLFGFHKATRTNNNRWNYPAYRRRPLGPLHPVNKSALVMVTKSGYIKLIYQNPDLRWGEISTELKTVGYLDGLLTHAALAPAEGSGISIATHSACGKVCFYRVQVKWDPPEWDQTIKPGGGSIAFPTPAFQVLHTKTEVLSAVFHPPAHDMDNITGFSPPNGEIYNLTHLEIITAPQLLPSTQAATGPCILAVASISPQNQLGQPPPCGLSSVLVRWQLDTMAQALHPSFDDVVSKKTASNPKSKIIFRRLDDIYFERYVVSIDYTEASSVLAITHDDSSISFFEARSMRPITENEDGNTVTSMPNAGFIFPIDASGLHIAFSPSGCIAAVLDGEGQFHLRYMEHSFGMEDGMYDSGKFTCAIAALALGYVRACGSDASADDILAVIVRQLNPDAQRTFVTEVYSILFTSVDFTEHDKLVNNQSIQKGLSMQAVLGFRSRFQPRAPSSTVSWIILNIRQIMVLLLTVSHYLKNGKDSTPSEPEVLRMVLGNVKWILDLAKYLVDDLLEIADTIPADRTSFTLSSKTYESPSLILVLSSIPRSFLRHIFRYLGRFPLTFKAANNLSGESYQLFASINDTIDQSSLKPDVCEKMLAHIDSIVTRTYEAAGFGSAERNAPEREMLITCSIPPVLQPAVMSILTETVPLVVRPGVERMALALYDYSWLGIGDDKRTELFKRTHDVDILKKNVGKVLDATVAKRRCVRCCEVSEDTCLPRSASMYRLIGKIGVLRTCVCGGSFAMENVEALDRVSLPVYR
Length918
PositionTail
OrganismBlastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.08
Grand average of hydropathy-0.039
Instability index43.11
Isoelectric point5.85
Molecular weight101274.02
Publications
PubMed=26439490

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07725
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.04|      21|      23|     118|     139|       1
---------------------------------------------------------------------------
  118-  139 (33.12/23.16)	VDSCGRIAIVTIMMSLNtVNQP
  144-  164 (39.92/23.70)	IDPDDDLAQPVGLMWLN.LNRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     197.45|      62|     430|     202|     417|       2
---------------------------------------------------------------------------
  348-  417 (93.61/295.98)	ATGPCILAVASISPqnqLGQPPPCGLSS....VLVRWQLDTMAQALhpsFDdvVSKKTASNPKSKIIFRRLDDI
  779-  844 (103.84/22.21)	APEREMLITCSIPP...VLQPAVMSILTetvpLVVRPGVERMALAL...YD..YSWLGIGDDKRTELFKRTHDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.67|      33|     430|      50|      83|       3
---------------------------------------------------------------------------
   50-   83 (60.32/44.26)	KIAWSKLGAIAYVsQDGQ.KVLLRYL.HCRP.DDGKW
  482-  517 (52.34/33.37)	HIAFSPSGCIAAV.LDGEgQFHLRYMeHSFGmEDGMY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.68|      36|     430|     202|     246|       4
---------------------------------------------------------------------------
  178-  218 (61.01/36.27)	RWNYPAYRRRPLG.........PLHPVNksalvMVTKSGYIKLIYQNPDL
  219-  268 (48.68/45.02)	RWGEISTELKTVGyldgllthaALAPAEgsgisIATHSACGKVCFYRVQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.60|      16|      16|     425|     440|       5
---------------------------------------------------------------------------
  425-  440 (27.47/20.01)	SIDYTEASSVLAITHD
  443-  458 (29.13/21.69)	SISFFEARSMRPITEN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07725 with Med16 domain of Kingdom Fungi
Unable to open file!