<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07724

Description CMGC/CDK/CDK8 protein kinase
SequenceMSLSNPPHSAGGGSLSDAASARSTHASRSSAGALNNNNNGNPSLGLKRSVQAAFDDTLEPKKSPGVGYASKVHIREKYHIVGFISSGTYGRVYKAIGRNGQKREFAIKKFKPDKEGEIIQYTGLSQSAIREMALCSELSHANVVHLEEIILEDKCIFMVFEYTEHDLLQIIHHHTQPQRHPIPAPMVKSILFQLLNGLLYLHSNWVLHRDLKPANILVTSTGAVRIGDLGLARLFYKPLNSLFSGDKVVVTIWYRAPELLLGSRHYTPAIDLWAVGCIFAELLSLRPIFKGEEAKMDSKKTVPFQRNQMLKIIEILGIPSKEAWPGLTSMPEYAQLQTLVLSRGGGHLSKLSNLEAWYHACVKAAGYPSSPSGSPGREGFDLLSRLLEYDPKKRLTAEEALKHPYFSIGTPVTANCFEGFAGKYPNRRVSQDDNDIRTSSLPGTKRSGLPDDTLTSRAAKRHKEG
Length465
PositionKinase
OrganismBlastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.08
Grand average of hydropathy-0.322
Instability index47.70
Isoelectric point9.34
Molecular weight51320.10
Publications
PubMed=26439490

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07724
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.99|      25|     395|      35|      61|       1
---------------------------------------------------------------------------
   35-   61 (40.91/30.78)	NNNNNGNPSL.GLKRSvqAAFDDTLEPK
  432-  457 (40.07/23.97)	DDNDIRTSSLpGTKRS..GLPDDTLTSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.36|      24|     331|       9|      32|       2
---------------------------------------------------------------------------
    9-   32 (40.87/23.93)	SAGGGSLSDAASARST.HASRSSAG
  342-  366 (40.49/23.65)	SRGGGHLSKLSNLEAWyHACVKAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.27|      19|      33|     225|     243|       3
---------------------------------------------------------------------------
  225-  243 (33.09/20.63)	RIGDLGLARLFYKPLNSLF
  255-  273 (35.18/22.37)	RAPELLLGSRHYTPAIDLW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07724 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSLSNPPHSAGGGSLSDAASARSTHASRSSAGALNNNNNGNP
2) RRVSQDDNDIRTSSLPGTKRSGLPDDTLTSRAAKRHKEG
1
427
42
465










Molecular Recognition Features






MoRF SequenceStartStop




NANANA