<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07723

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIIMDGTSANGPRREADHQQLVDGTLSTTTSLAPHNNGDYSNGPSHTEDATRLSNPSFDDSLPPELVHISQGFFSLGHLINRAAQQCWNDLTDLITELADPQSTATHVAAPPISTTNGKYTPSQSATENAQRKLRILEFAQAKRADFIKILVLSQWSRRAADVSRLIDIQAFIRMRYDCYNGAILSIGEMKRDLIRAQTANPDLAMALEVLSTGRVAAMQESSFVPPKPLTQKNMLKTLKKINKTIRTRLVLHDQIPSAFTKYLINDGRVTFKVPMEFEVDLSIAQENHSSQFFFVDIRFLFSPSPPKPTGRLLDELDNRVNAMLMHSGLPGCYNLLHNLVLSNKITILFHQAIELARGHWLDTLRVEVLHRTLVVQYWANRPGPKSWVEIGIKSGRRKDQTQDGSITETPFLGLRWMRDNKEVESKYIKFDMELLSIEAVLRSVIALHTSFLLESTYTRLLQGRLYASGALSASLQMSISEPGDCLFDVQLTKGRNLRVMIEPVSGAIIFRPTPLLLNRHDIDRSFERPIVDDILLRISRLRSAAVIEEVESLADALGWEIVNSRDIKNEDLRRIFPPNILRSVLFFRKSWECNWGVAYTCSMDGDNWWVVELRAPSSDEGPVSPQSAHMVTGRFGGLPERLNYGSFGKLDHALSGMLAIHANSRYLSELHGIHHFPPIRNLSLGPHLQVPSVFIRFRSRSLPSGLQISPPIITNKNPAIKDTVRLSFQGIDLSTQYAILLAHGTLSSEIKDLALPASHLDPTVTFQPNGCGFAMRFLTPVGQPMIIQLLARLQQLERVISTLETLKQKSLKPLSVNLSKIKFAYAADEDARASFNFNYHEQTLASDINSITLLSKQTPLMLLRMSIDFHPQNPHRRIKESLTATLNGLRPAAGSGTGLEAVLQLLVVTLPVLKALDRMTTESHVGHPANSGLQITARSSKIFYIRYASIRYRFCVHAGLRRDRVVWILREMTIAPEKAGRQPLENKLKEHIYGARGDGWQGLGNGAIAEYEKIGNLLSTLHRVMAEYISSEAGGASGSNTLGSRNGASGGGPGPAPDGRSGSSGGSGLGPEVRKAPQPQLSGRGAADSKSRLIPGQAGMGVDMQGRPGGLGGLGGTNTPKPASNGMAMGTQTQSDTKAVKQNTKIPQSNKSNHATGAMANGNNGNGNGNGSGSGSGSGGSRDVDVIMID
Length1193
PositionTail
OrganismBlastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.06
Grand average of hydropathy-0.262
Instability index42.43
Isoelectric point9.37
Molecular weight130771.73
Publications
PubMed=26439490

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07723
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     351.98|      90|     100|     979|    1073|       1
---------------------------------------------------------------------------
  621-  675 (60.11/28.13)	...SDEGPVSPQSAHMVTGRFGGL..PERLNYGS...FGKLDHALSGMLAIHANsrYLSELH.G....................................
  979- 1073 (151.03/96.68)	PEKAGRQPLENKLKEHIYGARGDG..WQGLGNGAiaeYEKIGNLLSTLHRVMAE..YISSEA.GGASGSNTLGSRNGASGGGPGpaPDGRSGSSGGSGLG
 1082- 1133 (83.62/43.19)	PQLSGRGAADSK.SRLIPGQAGMGvdMQG.............................................RPGGLGGLGG..TNTPKPASNGMAMG
 1143- 1186 (57.23/26.34)	VKQNTKIPQSNK.SNHATGAMANG..NNGNGNG.............................nGSGSGSGSGGSRD........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.00|      25|      99|     748|     772|       2
---------------------------------------------------------------------------
  748-  772 (43.72/31.85)	TLSSEIKDLAL.....PASHLDPTVTFQPN
  846-  875 (38.28/26.81)	TLASDINSITLlskqtPLMLLRMSIDFHPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.17|      33|      77|      22|      54|       6
---------------------------------------------------------------------------
   22-   54 (59.84/39.10)	QLVDGTLSTTTSLAP...HNNGDYSNGPSHTEDATR
   99-  134 (53.33/34.00)	ELADPQSTATHVAAPpisTTNGKYTPSQSATENAQR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07723 with Med14 domain of Kingdom Fungi
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