<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07720

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMEEIKIVGSSSAQWKTLLRRCLSQRTDASEFRAFAKLMLNRYSIPARRLIDIILALRCVTNVPWDPLIPLYVDTLHRLGSIKLEDILESLLAQSTVSQKQVAAQNGSTTKAPVSTLMTDYCIIHNATIAATSGHAPKTTSDAANTFSALAKWILALLSWNSSREPVGDPAASLTNSPDTLAVFESLGILFAALMSTEKAVNALSASGPKGWRNKLGQSLSEYIPLCGGVSIPLRDRLETLRKDFNLYGHDGEKSLEDAMMENVNISALEFESNVLDGSIINSRAGPYIYVNALLFGRPLVDDSMVVNYLNNRYGGDRMTLIEDLITAAFDVLSNGMYRNEPNRTMFIFRSFLVNKLPPFFAEMCASAINPIPMELCITRALSRIDPNAFPSFSEMFAMQGNSILSDVRQEFLFACALHKLIPEASIERLLGENPMQTLPVGGQLRREDLVSQINNNPERAEQLINELESMEGNAGTIAAAITEVMHNLCSRKETMTLKNICNSLSRRPLSLDVMLLFISPSTILRPLCALLDAWKWGEEQGESQPVYDEFGSILLLVLAFKYKYGLSHYDLGISNPDSFILRLLQHGCSSQRLEDLDEKQKNNLGAWITALFIAEGISDESMSSCSPQEFYFLVSTLFSQSLAACETGKLEFETLKGGFEYLLEPFLLPSLVMALTWLGHHIWESESDLTISLKLLLALVKPSSISGEAQEIHRTVLLITAKQLGDQLKGVRTRHLSRNDIKPILEALEPYHSFQRRSTARYGEVEGWASNPAGGGIVASIRNTFSSFVFWSTSPEISMTPPSYTHRQIVAGIRLVGAVRVLRGIIDELKLQAETGSGDLALDIAATLICAPLAESFAVERAAFHPVDPSKDAIPRCPILTLRDGLNLERESIPKLIDSDTLRAELIVRLSRRVDALTAVPQMPQEVSNIDVGNIMQGINLEREGMGMSGQRHDQGGEQSGQQNQGADDTGDLNDMLDAAVAAAAGGDGAGNGQGMGMSGIGEIGMGMGSGLDASIDDVLNGADMGVGNPEYLDLDMEGMF
Length1041
PositionTail
OrganismBlastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.07
Grand average of hydropathy-0.034
Instability index43.62
Isoelectric point4.96
Molecular weight113844.85
Publications
PubMed=26439490

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07720
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.84|      33|      33|     356|     388|       1
---------------------------------------------------------------------------
  354-  386 (60.65/39.78)	NKLPPF...FAEMCASAINPIPMELCITRALSRIDP
  387-  422 (54.19/34.75)	NAFPSFsemFAMQGNSILSDVRQEFLFACALHKLIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.93|      28|      31|     753|     782|       2
---------------------------------------------------------------------------
  753-  782 (44.97/36.98)	SFQRRSTARygEVEGWASNPAGGGIVASIR
  787-  814 (52.96/35.64)	SFVFWSTSP..EISMTPPSYTHRQIVAGIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     194.26|      50|      52|     925|     976|       3
---------------------------------------------------------------------------
  884-  923 (49.16/30.86)	................DGLNLERESIPKLIDSDTLRAELIVRLSRRVDALTAVPQM
  925-  976 (83.76/66.86)	QEVSNI...D.VGNimQGINLEREGMGMSGQRHDQGGEQSGQQNQGADDTGDLNDM
  979- 1025 (61.34/41.46)	AAVAAAaggDgAGN........GQGMGMSGIGEIGMGMGSG.LDASIDDVLNGADM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.83|      18|      36|     141|     158|       5
---------------------------------------------------------------------------
  141-  158 (29.63/20.26)	DAANTFSALAKWILALLS
  178-  195 (29.20/19.85)	DTLAVFESLGILFAALMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     232.17|      77|     346|     211|     297|       6
---------------------------------------------------------------------------
  211-  297 (106.05/88.16)	WRNKLGqsLSEYiPLcgGVSIPlrDRLeTLRkdFNLYGHDGEK..SLEDAMMENVN..ISALEFESNVLDGSIINSRAGPYIYVNALLFGR
  560-  640 (126.12/71.38)	FKYKYG..LSHY.DL..GISNP..DSF.ILR..LLQHGCSSQRleDLDEKQKNNLGawITALFIAEGISDESMSSCSPQEFYFLVSTLFSQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07720 with Med5 domain of Kingdom Fungi
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